Fibrinogen (Factor I)

Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.

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Networked: 15409 relevant articles (467 outcomes, 1904 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Neerman-Arbez, Marguerite: 44 articles (11/2022 - 03/2003)
2.	Rumley, Ann: 38 articles (04/2022 - 07/2002)
3.	Tracy, Russell P: 32 articles (10/2021 - 02/2002)
4.	Flick, Matthew J: 30 articles (01/2022 - 01/2005)
5.	Undas, Anetta: 28 articles (04/2022 - 06/2006)
6.	de Maat, Moniek P M: 27 articles (05/2022 - 08/2002)
7.	Lowe, Gordon D O: 27 articles (04/2022 - 07/2002)
8.	Degen, Jay L: 27 articles (01/2021 - 12/2002)
9.	Peyvandi, Flora: 26 articles (01/2022 - 08/2002)
10.	Folsom, Aaron R: 26 articles (01/2021 - 12/2002)

Related Diseases

1.	Hemorrhage 01/01/2023 - "Fibrinogen concentrate is cost-effective when compared with cryoprecipitate in most bleeding adult patients who underwent cardiac surgery with acquired hypofibrinogenemia requiring fibrinogen replacement. " 01/01/2020 - "The efficacy of fibrinogen infusions has been demonstrated, especially for the management of acute bleeding with an excellent response based on investigator rating. " 12/18/2020 - "Reaction time (R), kinetic time (K), maximum amplitude (MA) and maximum amplitude of fibrinogen (MA-fib) improved significantly (P <  0.001 for all), and MA-fib correlated significantly with the clinical bleeding evaluation (r = 0.70, P <  0.001). " 06/02/2015 - "Fibrinogen concentrate limits postoperative bleeding after complex heart surgery, leading to a significant reduction in allogeneic blood products transfusions. " 05/01/2005 - "On multiple logistic regression analysis, cortical location of bleeding (odds ratio 3.79 (95% confidence interval 1.2 to 12.01); p = 0.023), high CSS score (OR 2.3 (1.6 to 3.1); p<0.0001), and low fibrinogen concentrations (OR 0.92 (0.87 to 0.97); p = 0.001) were independent predictors of good outcome. "
2.	Thrombosis (Thrombus) 10/13/2023 - "FgaWT/EK mice also displayed reduced thrombus incidence and a significant reduction in thrombus mass relative to FgaWT/WT mice following IVC stasis, suggesting partial expression of nonpolymerizable fibrinogen was sufficient for conferring protection. " 01/01/2010 - "There was a significant reduction in thrombus formation in the 4 h group compared with control (median weight, 0.000 versus 0.565mg/mm, P < .01; median % 125I-fibrinogen accretion, 0.0 versus 42.0%, P < .01). " 08/01/1975 - "We have examined radioiodinated fibrinogen prepared at high levels of iodination as an agent for improved in vivo thrombus detection. " 01/01/2022 - "The receiver operating characteristic curve (ROC curves) showed that NLR was more effective in predicting the progression of future thrombotic events than age ≥ 60 years, history of previous thrombosis, and fibrinogen. " 10/08/1983 - "Its field of application is limited in that the pelvic veins (iliac veins excepted) and the deep femoral vein are imperfectly explored or unexplored, but it is superior to other methods - such as labelled fibrinogen, Döppler ultrasonography or rheography - which are less sensitive, less specific and unable to localize precisely the site and extension of the thrombosis. "
3.	Wounds and Injuries (Trauma) 08/01/2012 - "The routinely used clotting parameters markedly improved between admission to the trauma bay and ICU admission: Quick 61% versus 97% (p < 0.001), partial prothromboplastin time (PTT) 50 s versus 42 s (not significant), fibrinogen 1.7 g/l versus 2.15 g/l (not significant). " 06/01/2014 - "Randomized trials are warranted to determine whether FC improves outcomes in prehospital management of trauma patients or whether FC is superior to another source of fibrinogen in early hospital management of trauma patients." 12/21/2021 - "In trauma-induced coagulopathy, fibrinogen concentrate is the preferred first-line treatment for hypofibrinogenaemia. " 01/01/2020 - "Therefore, we evaluated whether early administration of fibrinogen concentrate (FC) was associated with improved survival in severe trauma patients. " 01/01/2020 - "Early administration of fibrinogen concentrate is associated with improved survival among severe trauma patients: a single-centre propensity score-matched analysis."
4.	Neoplasms (Cancer) 08/01/2015 - "Receiver operating characteristic analyses showed that including plasma fibrinogen level alongside traditional factors (tumor stage and CA 19-9) significantly improved prognostic prediction capability (traditional model area under the curve of 0.62 versus combined model area under the curve of 0.708; P = 0.016). " 01/01/2016 - "In a univariate survival analysis, tumor stage, tumor size, lymph node involvement (p<0.001/p<0.001) and plasma fibrinogen (p<0.001/p<0.001) levels were associated with disease-free and overall survival, but just lymph nodes involvement (p<0.001, hazard ratio [HR] = 2.9, 95% confidence interval [CI] = 1.6-5.3/p = 0.006, HR = 3.2, 95% CI = 1.4-7.3) and plasma fibrinogen levels (p = 0.006, HR = 3.4, 95% CI = 1.4-8.3/p = 0.002, HR = 10.1, 95% CI = 2.3-44.6) were associated with disease-free and overall survival in a multivariate survival analysis, respectively. " 03/01/2012 - "In a multivariate survival analysis, tumor stage (p=0.006/p=0.02) and lymph node involvement (p<0.001/p<0.001), but neither histological grade (p=0.2/p=0.9) nor plasma fibrinogen levels (p=0.6/p=0.6) were associated with disease-free and overall survival, respectively. " 04/30/1983 - "In these patients, the behavior of fibrinogen was normal, suggesting that the parameters studied are related to the presence of the tumor, and can be useful in monitoring the state of remission." 08/01/1977 - "A combination of the large tumour concentration of I-fibrinogen, an increased catabolic rate induced by chemical modification, and the exceptional nuclear properties of 123I for scintigraphic imaging, could lead to a very useful radiodiagnostic procedure for cancer."
5.	Insulin Resistance 01/01/2021 - "Patients with elevated fibrinogen, CRP, and insulin resistance had a significantly greater incidence of progression to T2DM. " 05/01/2006 - "There was an improvement in insulin resistance, as evidenced by lower HOMA-R and higher QUICKI index, as well as a decrease in CRP and fibrinogen levels. " 05/01/2010 - "The aim of this study was to assess whether plasma fibrinogen levels were associated with MS and insulin resistance in a rural population of China. " 11/01/1999 - "Fibrinogen was associated with insulin resistance in the whole study group. " 04/01/1994 - "The present study aimed at testing a possible relationship between hemorrheologic factors, such as hematocrit, fibrinogen, and whole-blood viscosity, and insulin sensitivity in healthy humans. "

Related Drugs and Biologics

1.	C-Reactive Protein
2.	Thrombin
3.	fibrin fragment D (D-dimer)
4.	Fibrin
5.	Lipids
6.	Proteins (Proteins, Gene)
7.	LDL Cholesterol
8.	Heparin (Liquaemin)
9.	Cholesterol
10.	Triglycerides (Triacylglycerol)

Related Therapies and Procedures

1.	Therapeutics
2.	Blood Component Removal (Apheresis)
3.	Resuscitation
4.	Platelet Transfusion (Blood Platelet Transfusions)
5.	Aftercare (After-Treatment)