Fetofetal Transfusion (Twin Transfusion Syndrome)

Passage of blood from one fetus to another via an arteriovenous communication or other shunt, in a monozygotic twin pregnancy. It results in anemia in one twin and polycythemia in the other. (Lee et al., Wintrobe's Clinical Hematology, 9th ed, p737-8)
Also Known As:
Twin Transfusion Syndrome; Cross Transfusion, Intrauterine; Cross-Transfusions, Intrauterine; Fetofetal Transfusions; Intrauterine Cross Transfusion; Intrauterine Cross-Transfusions; Syndrome, Twin Transfusion; Syndromes, Twin Transfusion; Transfusion Syndrome, Twin; Transfusion Syndromes, Twin; Transfusion, Fetofetal; Transfusion, Twin; Transfusions, Fetofetal; Transfusions, Twin; Twin Transfusion Syndromes; Twin Transfusions; Cross-Transfusion, Intrauterine; Intrauterine Cross-Transfusion; Twin Transfusion
Networked: 68 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Hydrops Fetalis (Fetal Edema)
2. Premature Birth (Birth, Premature)
3. Polyhydramnios
4. Anemia
5. Polycythemia (Erythrocytosis)


1. Lopriore, E: 5 articles (01/2013 - 01/2007)
2. Vandenbussche, F P H A: 4 articles (10/2008 - 01/2007)
3. Deprest, J: 4 articles (10/2008 - 05/2002)
4. Johnson, Anthony: 3 articles (08/2013 - 01/2009)
5. Moise, Kenneth J: 3 articles (08/2013 - 02/2008)
6. van den Wijngaard, Jeroen P H M: 3 articles (04/2008 - 04/2005)
7. van Gemert, Martin J C: 3 articles (04/2008 - 04/2005)
8. Ross, Michael G: 3 articles (04/2007 - 04/2005)
9. Walther, F J: 2 articles (01/2013 - 01/2007)
10. Fisk, N M: 2 articles (05/2009 - 09/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Fetofetal Transfusion:
1. Twin twin transfusion syndromeIBA
05/01/2009 - "Twin-twin transfusion syndrome (TTTS) is a fascinating condition in which fetuses of identical genotype adopt discordant cardiovascular phenotypes, secondary to unbalanced placental inter-twin transfusion. "
02/01/2008 - "The twin-to-twin transfusion syndrome (TTTS) is a severe complication of monochorionic twin pregnancies, caused by a net inter-twin transfusion of blood from one fetus (the donor) towards the other fetus (the recipient) through placental anastomoses. "
11/01/2005 - "To report the initial experience in our country with a new technique for twin to twin transfusion syndrome (TTTS) treatment, using laser to coagulate the placental vessels responsible for the twin transfusion during gestation. "
02/01/1995 - "We hypothesized that this unexpected event was related to reversed acute twin-twin transfusion, and concluded that fetal hydrops remission in twin-twin transfusion syndrome must not be considered as a reassuring prognostic index but as an indication of the need for continuing biophysical monitoring."
09/01/2002 - "In twin-twin transfusion syndrome, recipient fetuses had increased aortic and pulmonary velocities compared with their donor co-twins (mean (SD): 0.73 (0.23) m/s and 0.63 (0.14) m/s), respectively, v 0.53 (0.16) m/s and 0.48 (0.10) m/s in donor twins; p = 0.003 (aortic) and < 0.0001 (pulmonary)), and also in comparison with twin 1 and twin 2. The overall prevalence of congenital heart disease was increased above that in singletons (3.8% v 0.56%; 6.9% in twin-twin transfusion v 2.3% in uncomplicated monochorionic diamniotic twins), with inter-twin discordance for defects. "
2. Hemoglobins (Hemoglobin)IBA
3. Carbon MonoxideIBA
4. Messenger RNA (mRNA)IBA
5. Atrial Natriuretic Factor (ANF)IBA
6. Digoxin (Digitek)FDA LinkGeneric
8. SteroidsIBA
9. NeodymiumIBA
10. IronIBA

Therapies and Procedures

1. Laser Therapy (Surgery, Laser)
2. Lasers (Laser)
3. Multifetal Pregnancy Reduction
4. Light Coagulation
5. Laser Coagulation