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Premature Rupture Fetal Membranes

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Spontaneous tearing of the membranes surrounding the FETUS any time before the onset of OBSTETRIC LABOR. Preterm PROM is membrane rupture before 37 weeks of GESTATION.

Also Known As:

Fetal Membranes, Premature Rupture; PROM (Pregnancy); Premature Rupture of Fetal Membranes; Preterm PROM (Pregnancy); Preterm Premature Rupture of Fetal Membranes; Membrane Premature Rupture (Pregnancy); Membrane Premature Ruptures (Pregnancy); PROM, Preterm (Pregnancy); Premature Rupture of Membrane (Pregnancy)

Networked: 66 relevant articles (1 outcomes, 9 trials/studies)

Relationship Network

Disease Context: Research Results

Female Urogenital Diseases and Pregnancy Complications
- Pregnancy Complications: 986
  - Obstetric Labor Complications: 34
    - Premature Rupture Fetal Membranes: 66
      - Chorioamnionitis: 1115

Related Diseases

1.	Premature Obstetric Labor (Premature Labor)
2.	Ehlers-Danlos Syndrome (Syndrome, Ehlers-Danlos)
3.	Retained Placenta
4.	Pregnancy Complications
5.	Placenta Previa

Experts

1.	Abdelazim, Ibrahim A: 4 articles (09/2014 - 02/2013)
2.	Torbé, Andrzej: 3 articles (01/2015 - 01/2009)
3.	Kwiatkowski, Sebastian: 3 articles (01/2015 - 01/2009)
4.	Rzepka, Rafał: 3 articles (01/2015 - 01/2009)
5.	Dołegowska, Barbara: 3 articles (01/2015 - 01/2009)
6.	Chlubek, Dariusz: 2 articles (09/2009 - 01/2009)
7.	Czajka, Ryszard: 2 articles (09/2009 - 01/2009)
8.	Sağol, Sermet: 2 articles (06/2004 - 10/2002)
9.	Fortunato, S J: 2 articles (06/2001 - 06/2000)
10.	Lombardi, S J: 2 articles (06/2001 - 06/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Premature Rupture Fetal Membranes:

1.	alpha-Fetoproteins (AFP)IBA 10/01/1995 - "This study has confirmed a high clinical efficacy of the improved AFP test kit as a method of diagnosis of premature rupture of fetal membranes."
2.	Insulin (Novolin)FDA Link 04/01/2014 - "This study was designed to detect the accuracy of the insulin-like growth factor binding protein-1 (IGFBP-1) in diagnosing premature rupture of fetal membranes. " 06/01/2013 - "This study was designed to compare the accuracy of placental alpha microglobulin-1 (PAMG-1) versus insulin-like growth factor binding protein-1 (IGFBP-1) to diagnose premature rupture of fetal membranes (PROM). " 04/01/2014 - "Insulin-like growth factor binding protein-1 (Actim PROM test) for detection of premature rupture of fetal membranes." 06/01/2013 - "Placental alpha microglobulin-1 (AmniSure test) versus insulin-like growth factor binding protein-1 (Actim PROM test) for detection of premature rupture of fetal membranes."
3.	CollagenIBA 11/01/1990 - "Short communication: placental collagen and premature rupture of fetal membranes." 01/01/1988 - "Premature rupture of fetal membranes changes in collagen type." 01/01/2006 - "This electron microscopy study focused on collagen fibril orientation and unusual shapes in the dermis of Ehlers-Danlos syndrome (EDS) and related entities, including spontaneous cervical artery dissection syndrome and recurrent preterm premature rupture of fetal membranes syndrome. " 07/01/2009 - "To detect the expression of collagen III, CTGF and TNF-alpha in human fetal membranes with premature rupture of fetal membranes (PROM) and non-PROM, and explore their roles in the pathogenesis of PROM. " 04/01/2003 - "Collagen synthesis during pregnancy, vitamin C availability, and risk of premature rupture of fetal membranes."
4.	Leukocyte Elastase (Neutrophil Elastase)IBA 02/01/1993 - "[Importance of plasma PMN granulocyte elastase concentration determination in pregnant patients with premature rupture of fetal membranes]." 01/01/2009 - "[The assessment of neutrophil elastase measurements usefulness in pregnant women with premature rupture of fetal membranes and chorioamnionitis suspicion]." 10/01/2003 - "The aim of the study was to evaluate and compare the usefulness of determination granulocyte elastase, (EG) C-reactive protein (CRP) and white blood cell count (WBC) in prediction of chorioamninitis in pregnant women after premature rupture of fetal membranes. " 01/01/1989 - "[The value of leukocytes, C-reactive protein and granulocyte elastase in patients with premature rupture of fetal membranes and amniotic infection]."
5.	Fibronectins (Fibronectin)IBA 02/01/2013 - "This study was designed to detect the accuracy of the fetal fibronectin (Quick Check fFN test(®)) in diagnosing premature rupture of fetal membranes. " 09/01/2014 - "To compare accuracy of fetal fibronectin (fFN) versus placental alpha microglobulin-1 for detection of premature rupture of fetal membranes (PROM). " 09/01/2014 - "Fetal fibronectin (Quick Check fFN test) versus placental alpha microglobulin-1 (AmniSure test) for detection of premature rupture of fetal membranes." 02/01/2013 - "The Quick Check fFN test(®) for detection of the fetal fibronectin in the vaginal fluid is a simple bedside test, more sensitive, and specific than Ferning and Nitrazine tests, it can be used as complimentary test to confirm the clinical diagnosis of premature rupture of fetal membranes." 02/01/2013 - "Fetal fibronectin (Quick Check fFN test(®)) for detection of premature rupture of fetal membranes."
6.	C-Reactive ProteinIBA 10/01/2003 - "The aim of the study was to evaluate and compare the usefulness of determination granulocyte elastase, (EG) C-reactive protein (CRP) and white blood cell count (WBC) in prediction of chorioamninitis in pregnant women after premature rupture of fetal membranes. " 01/01/1989 - "[The value of leukocytes, C-reactive protein and granulocyte elastase in patients with premature rupture of fetal membranes and amniotic infection]."
7.	Matrix Metalloproteinase 2 (Gelatinase A)IBA 06/01/2000 - "Induction of matrix metalloproteinase 2 may be a function of p53 gene expression increase in premature rupture of fetal membranes." 06/01/2000 - "Increased matrix metalloproteinase 2 expression and activity are associated with premature rupture of fetal membranes. " 06/01/2000 - "Quantitative competitive polymerase chain reaction documented a 10-fold increase in the expression of the gene for matrix metalloproteinase 2 in premature rupture of fetal membranes with respect to term and preterm labor. " 06/01/2000 - "This study was undertaken to investigate the expression pattern of apoptotic elements in pregnancy complications that may cause increased expression of the gene for matrix metalloproteinase 2. Amniochorial membranes were collected from the following groups of women: (1) women with premature rupture of fetal membranes, (2) women with preterm labor and intact membranes, and (3) women with term labor after vaginal delivery. "
8.	Kynurenic Acid (Kynurenate)IBA 12/01/2001 - "The aim of the study was to evaluate the influence of premature rupture of fetal membranes on kynurenic acid (KYNA) levels in venous and arterial umbilical cord blood of neonates. " 12/01/2001 - "[Influence of premature rupture of fetal membranes on kynurenic acid concentration in umbilical cord blood]."
9.	Anti-Bacterial Agents (Antibiotics)IBA 01/01/2011 - "[Antibiotics in premature rupture of fetal membranes: is there a benefit for the newborn infant?]." 01/01/1984 - "[Use of antibiotics in newborn infants following premature rupture of fetal membranes]." 11/01/1982 - "[Use of antibiotics for premature infants after premature rupture of fetal membranes]." 01/01/1988 - "[Preventive administration of antibiotics before cesarean section conducted after premature rupture of fetal membranes]." 02/01/1992 - "The possible beneficial effect of antibiotics in prevention of preterm premature rupture of fetal membranes and retardation of the onset of labor in some patients with clinical or subclinical infection was explained via their antibacterial efficacy. "
10.	Dinoprostone (PGE2)FDA Link 05/01/1997 - "The first group (n = 219) included pregnant women at term with premature rupture of fetal membranes and unfavourable pelvic score in whom labor was induced by intracervical dinoprostone. " 01/01/1991 - "[Intravaginal PgE2 administration for inducing labor in premature rupture of fetal membranes]." 09/01/1990 - "[Peroral and intracervical administration of prostaglandin E2 for stimulation of term labor in premature rupture of fetal membranes]." 05/01/1991 - "[Comparison of prostaglandin E2 and oxytocin infusions for induction of labor in primiparas at term with an unripe cervix and premature rupture of fetal membranes]."

Therapies and Procedures

1.	Cesarean Section (Caesarean Section) 09/01/1991 - "[Maternal morbidity after abdominal cesarean section in relation to bacterial amniotic fluid colonization and premature rupture of fetal membranes]." 01/01/1990 - "[Clinical, histopathological and bacteriological evaluation of the sequelae of premature rupture of fetal membranes in parturients after cesarean section]." 03/01/1988 - " There was no difference between the study groups and the controls in premature rupture of fetal membranes, placenta previa, cesarean sections, manual removal of placenta, retained secundine, postpartum hemorrhage, low birth weight, Apgar score less than 6, congenital abnormalities, or perinatal mortality. " 01/01/1988 - "[Preventive administration of antibiotics before cesarean section conducted after premature rupture of fetal membranes]."
2.	Tocolysis 01/01/1991 - "[Preventive tocolysis in premature rupture of fetal membranes]." 01/01/1993 - "[Tocolysis with hexoprenaline in premature rupture of fetal membranes. "
3.	Prenatal Care 04/01/1990 - "It is concluded that upon premature rupture of fetal membranes, prenatal care should focus on oligohydramnios, because if this condition is prolonged, the risk of pulmonary hypoplasia increases accordingly." 10/01/2001 - "Factors with positive and negative associations with severe intracranial hemorrhage are listed in order of decreasing statistical significance: gestational age (negative), surfactant (positive), antenatal indomethacin (positive), neonatal transport (positive), cesarean birth (negative), poor prenatal care (positive), 5-minute Apgar score of < 7 (positive), chorioamnionitis (positive), antenatal terbutaline (negative), preterm premature rupture of fetal membranes (negative), and abruption (positive). "
4.	Induced Labor 01/01/2010 - "Factors significantly associated with pre-term delivery were low socio-economic class, previous pre-term delivery, antepartum hemorrhage, premature rupture of fetal membranes, urinary tract infection, pregnancy induced hypertension, induced labor, and booking elsewhere outside the teaching hospital." 01/01/1995 - "[Premature rupture of fetal membranes at term: an indication for induced labor with prostaglandins?]."
5.	Neonatal Intensive Care 01/01/2013 - "The other two cases (33.3%) presented with preterm premature rupture of fetal membranes (PPROM) which led us to undo the stitch with eventual delivery of live-born premature fetuses which died in the neonatal intensive care unit because of complications of prematurity and neonatal infection. "