Fetal Diseases (Embryopathy)

05/01/2012 - "Oxidative stress (OS) has been implicated to be responsible because various antioxidants have been demonstrated to be beneficial in diabetic embryopathy. "
09/01/2016 - "Animal studies have revealed an involvement of oxidative stress in diabetic embryopathy and treatment with antioxidants can reduce embryonic abnormalities. "
04/01/1997 - "The current study sought to determine whether a dietary cocktail of deficient substrates and antioxidant could reduce the incidence of diabetic embryopathy to the background rate in an in vivo rat model. "
11/13/2015 - "Studying the effect of natural compounds with antioxidant properties and minimal toxicities on diabetic embryopathy may lead to the development of new and safe dietary supplements. "
03/01/2013 - "Oxidative stress (OS) has been implicated in these effects because of the beneficial effects of several antioxidants in diabetic embryopathy. "

07/01/2005 - "Previous studies have suggested that diabetic embryopathy is associated with increased level of oxidative stress and disturbed arachidonic acid metabolism. "
03/01/1993 - "We conclude that CsA causes abnormal embryonic development in mouse embryo culture and that the mechanism of CsA-induced embryopathy involves inhibition of the arachidonic acid pathway."
10/01/1988 - "The experimental use of arachidonic acid in the prevention of diabetes-related embryopathy is a new and potentially valuable tool. "
10/01/1986 - "Arachidonic acid prevents hyperglycemia-associated yolk sac damage and embryopathy."
01/01/1987 - "Arachidonic acid (AA) prevents neural tube/defects, cleft palate, and micrognathia in the rat models of diabetic embryopathy and neural tube defects in the mouse embryo culture model. "

03/01/1997 - "These data demonstrate that myo-inositol supplementation reduces the incidence of diabetic embryopathy and may serve as a pharmacologic prophylaxis against diabetes-induced congenital malformations."
10/01/1990 - "These results suggest that myo-inositol depletion is involved in the mechanism of diabetic embryopathy."
12/01/1991 - "We have previously shown that myo-inositol depletion in the embryonic tissue at a critical stage of organogenesis has a crucial role in hyperglycemia-induced embryopathy. "
02/01/1998 - "Dietary myo-inositol therapy in hyperglycemia-induced embryopathy."
12/01/1991 - "This study tested whether myo-inositol depletion in early organogenesis contributes to the pathogenesis of streptozocin-induced diabetic embryopathy. "

02/01/1994 - "Warfarin treatment was safe and effective and was not associated with embryopathy. "
01/01/2001 - "Recent studies suggest that a warfarin dose of less than 5 mg and an INR of less than 3 does not induce embryopathy and is associated with a low rate of fetal complications (15%). "
04/07/2018 - "Low-dose warfarin is associated with a lower risk of warfarin-related fetopathy but the risk of embryopathy seems unchanged."
01/01/2018 - "However, warfarin throughout pregnancy ≤5 mg per day may be an alternative choice, if the risk of embryopathy is accepted by the pregnant woman."
04/01/2014 - "Warfarin treatment is the best regimen against thromboembolic complications, but its use in the first trimester can result in embryopathy. "

01/01/2009 - "A healthy male infant was born 2,560 g, Apgar scores 8 and 10 at 1 and 5 min. No coumarin embryopathy was revealed and the postoperative course of the mother was uneventful. "
06/01/2005 - "Three had no further anomaly; one child had additional abnormalities due to coumarin embryopathy. "
08/01/2002 - "The role of coumarin embryopathy has been overstated. "
04/01/2002 - "Coumarin embryopathy: long-term follow-up of two cases."
12/18/2000 - "Two children in this group, however, were born with signs of coumarin embryopathy and one of these displayed a deficit in height at school age. "

03/01/1999 - "Coumarin derivatives were safe and effective and did not lead to embryopathy."
11/01/2002 - "Coumarins can cause embryopathy and other adverse effects in the fetus. "
01/01/1980 - "In addition to the expected hemorrhagic complications, fetal effects of coumarin derivative administration include a specific embryopathy and central nervous system abnormalities. "
01/01/2005 - "Coumarins are unsuitable for use during pregnancy because of embryopathy and risk of fetal bleeding. "
04/01/2011 - "Coumarin derivatives are associated with an elevated risk of hemorrhage as well as coumarin embryopathy; recent studies have shown that the latter risk is low and dose-dependent. "

01/01/1992 - "The similarity observed in the malformation syndrome induced by both all-trans and 13-cis retinoic acid in the cynomolgus monkey and 13-cis retinoic acid embryopathy in humans supports this macaque species as a model for further developmental toxicity studies of vitamin A-related compounds."
12/01/1995 - "These observations suggest that altered vitamin A function is a potential factor in the embryopathy of prenatal ethanol exposure."
10/01/1995 - "Although the craniofacial anomalies resemble the abnormalities described in classical "retinoic acid embryopathy," limb anomalies were seldomly reported after maternal use of vitamin A congeners. "
10/01/2008 - "Besides folic acid administered in appropriate doses (>400 mug), that it is able to prevent some fetal diseases, such as the closure of the neural tube, other vitamins such as vitamin A are very effective in ensuring an optimal state of health of the mother and slowing the growth of uterine myomas."

07/01/2015 - "The present study evaluates the therapeutic efficacy of cell suspension of Spirulina platensis (SP) on estrous cycle, fetal development and embryopathy in alloxan (AXN) induced hyperglycemic mice. "

07/01/2015 - "The present study evaluates the therapeutic efficacy of cell suspension of Spirulina platensis (SP) on estrous cycle, fetal development and embryopathy in alloxan (AXN) induced hyperglycemic mice. "

11/01/2020 - "The study revealed the critical involvement of p70S6K1 in the pathogenesis of diabetic embryopathy."
11/01/2020 - "We also examined whether p70S6K1 deficiency restores autophagy and therefore relieves endoplasmic reticulum stress and inhibits maternal diabetes-induced apoptosis, which leads to reduction in neural tube defect incidence in diabetic embryopathy. "
11/01/2020 - "Deficiency of the oxidative stress-responsive kinase p70S6K1 restores autophagy and ameliorates neural tube defects in diabetic embryopathy."

02/01/1998 - "This therapy holds promise for use as a dietary prophylaxis against diabetic embryopathy."
01/01/2007 - "Therefore, further studies addressing their role in the mechanisms underlying diabetes-induced embryopathies are needed to evaluate the safety of such therapies for diabetic women of childbearing age."
05/01/1992 - "These studies reveal new information on fetal development and provide a baseline from which to evaluate either fetal disease or the response to therapy."
10/01/2022 - "Understanding how transporters are up- or downregulated during pathology is important in assessing possible exposures of the fetus to potentially harmful chemicals in the environment as well as the disposition of novel therapeutics intended to treat placental and fetal diseases. "
01/01/2019 - "Prenatal stem cell-based regenerative therapies have progressed substantially and have been demonstrated as effective treatment options for fetal diseases that were previously deemed untreatable. "

01/01/2001 - "Coumarin agents provide adequate protection against these complications but their use was associated in our series with an increased abortion rate (26.7%) and with an incidence of coumarin embryopathy of 4.1%. "

06/15/1962 - "[The value of cesarean section in the treatment of fetal diseases]."
02/13/1991 - "A few fetal diseases may benefit from surgical treatment before birth, but hysterotomy and subsequent delivery by cesarean section pose a risk to the otherwise unaffected mother. "
11/01/2013 - "The decrease in primary cesarean section rate may be attributed to several changes in medical policies in the Department, such as the implementation of an external fetal version program, the induction of labor only after the 41st week of gestation in low-risk pregnancies and the trial for vaginal birth in maternal-fetal disease. "
09/01/2011 - "Analysis of risk factors in children with paraparesis form of development revealed complicated pregnancy such as maternal diseases, fetal growth retardation or placental immaturity in 48% of these children; 26% of children were born before or after the term, and 34% had complications during delivery such as cesarean section or breech birth. "

05/06/1992 - "[Intrauterine transplantation with fetal stem cells cures fetal diseases]."
06/01/2005 - "These results provide useful reference values for future studies of maternal - fetal disease transmission, vaccine and drug evaluation in non-human primate pregnancy, as well as fetal programming and immune modulation, gene therapy and the use of UCB as a source of stem cells for research and transplantation. "

03/01/2011 - "increasing numbers of studies that attempt to introduce the Tei index as part of fetal assessment in different conditions (corrected diaphragmatic hernia, supraventricular tachycardia, fetal inflammatory response, cystic adenomatoid disease, fetal-fetal transfusion, etc.). "
10/01/1998 - "Regression analysis revealed no correlation between the global developmental quotient and gestational age at the first intrauterine transfusion, gestational age at birth, or the severity of the fetal hemolytic disease (fetal hematocrit, fetal bilirubin, presence of hydrops fetalis, total number of intrauterine transfusions, duration of neonatal phototherapy, and number of neonatal exchange transfusions). "