Fetal Hypoxia

11/11/2023 - "Meanwhile, in vivo experiments by melatonin injection ameliorated oxidative stress of ovary in fetal-hypoxia-treated mice and improved their low fertility. "
11/11/2023 - "Our data found that fetal hypoxia causes ovarian GCs excessive autophagy leading to low fertility in neonatal female mice and mitigated by melatonin. "
11/11/2023 - "This research aimed to explore the mechanism that fetal hypoxia damages reproductive function in neonatal female mice and attempt to improve the reproductive function by treating with melatonin in vivo and in vitro. "
11/11/2023 - "However, the potential mechanisms by which fetal hypoxia damages reproductive function in neonatal female mice and the melatonin effects on this problem remain unclear. "
11/11/2023 - "Fetal hypoxia expose caused autophagy in ovary granulosa cells via PI3K/Akt/FoxO1 pathway and mitigated by melatonin subheading."

09/01/1999 - "Increased injury following intermittent fetal hypoxia-reoxygenation is associated with increased free radical production in fetal rabbit brain."
07/01/1995 - "We propose an integrative heuristic model hypothesizing that these permissive and provocative factors increase the likelihood of FAS/ARBDs because they potentiate two related mechanisms of alcohol-induced teratogenesis, specifically, maternal/fetal hypoxia and free radical formation."
07/01/2009 - "Fetal hypoxia is an important determinant of neonatal encephalopathy caused by birth asphyxia, in which hypoxia-induced free radical formation plays an important role. "
08/01/2004 - "This issue has not been resolved in a clinical study, but an animal study reported enhanced formation of free radicals after an episode of fetal hypoxia in the group receiving supplementary oxygen. "
07/01/2009 - "Maternal treatment with allopurinol, will cross the placenta during fetal hypoxia (primary outcome) and reduce S-100B and free radical formation (secondary outcome). "

09/01/2015 - "It is, perhaps, time to link blood-borne cytokine signaling with alterations in the course of fetal brain development, especially after transient fetal hypoxia. "
01/01/2023 - "The objectives of the study were to determine (1) fetal and/or placental contributions to synthesis and/or clearance of inflammatory and anti-inflammatory cytokines in term pregnancies complicated by chorioamnionitis and (2) whether this differs in pregnancies further complicated by fetal hypoxia. "
08/01/2018 - "The utero-placental ischemia induced by pregnancy-induced hypertension (PIH) could lead to fetal hypoxia and proinflammatory cytokine release, which are associated with the development of neonatal necrotizing enterocolitis (NEC). "
06/01/1999 - "These findings suggest the glial reaction of cytokines and free radicals induced by fetal hypoxia may contribute to the occurrence of brain injury."
01/01/2017 - "Deleterious exposures in utero include fetal hypoxia, increased nutrient supply, inflammation and altered gut microbiota that might produce metabolic clues, including fatty acids, metabolites, endotoxins, bile acids and cytokines, which prime the infant liver for NAFLD in a persistent manner and increase susceptibility to NASH. "

01/01/2018 - "We found no proof that allopurinol administered to labouring women with suspected fetal hypoxia improved long-term developmental and behavioral outcome. "
01/01/2018 - "Behavioral and neurodevelopmental outcome of children after maternal allopurinol administration during suspected fetal hypoxia: 5-year follow up of the ALLO-trial."
01/01/2018 - "Labouring women in whom the fetus was suspected to have fetal hypoxia were randomly allocated to receive allopurinol or placebo. "
01/01/2018 - "To evaluate the long-term neurodevelopmental and behavioral outcome of antenatal allopurinol treatment during suspected fetal hypoxia. "
05/01/2015 - "Maternal treatment with allopurinol during fetal hypoxia did not significantly lower neuronal damage markers in cord blood. "

09/01/2013 - "The measurement of amniotic Epo level combined with amniotic TnT level is effective for determining the severity of fetal hypoxia."
10/01/2005 - "To determine if prenatally measured cardiac troponin T in the amniotic fluid (Am-TnT) could be used as a marker of fetal myocardial hypoxia and necrosis in pathological pregnancy characterized by increased concentration of amniotic fluid erythropoietin (Am-EPO) as a sign of chronic fetal hypoxia. "

09/13/2011 - "Hypoxia resulted in overactivation of LPA(1) through selective inhibition of G protein-coupled receptor kinase 2 expression and activation of downstream pathways including G(αi) and Ras-related C3 botulinum toxin substrate 1. These data identify stereotyped and selective hypoxia-induced cerebral cortical disruption requiring LPA(1) signaling, inhibition of which can reduce or prevent disease-associated sequelae, and may take us closer to therapeutic treatment of fetal hypoxia-induced CNS disorders and possibly other forms of hypoxic injury."

09/13/2011 - "Hypoxia resulted in overactivation of LPA(1) through selective inhibition of G protein-coupled receptor kinase 2 expression and activation of downstream pathways including G(αi) and Ras-related C3 botulinum toxin substrate 1. These data identify stereotyped and selective hypoxia-induced cerebral cortical disruption requiring LPA(1) signaling, inhibition of which can reduce or prevent disease-associated sequelae, and may take us closer to therapeutic treatment of fetal hypoxia-induced CNS disorders and possibly other forms of hypoxic injury."

01/01/2017 - "This study is an important step in facilitating accurate, noninvasive assessments of fetal blood oxygen content, a valuable diagnostic parameter in the identification and treatment of fetal hypoxia. "
10/05/2012 - "This safety study of HbV use in the pregnant mother and fetus will contribute to a possible application of HbV as a potential treatment for fetal hypoxia by supplying oxygen through the placenta."
01/01/1996 - "Because oxygen transport takes place within the terminal villi, we undertook the first detailed studies of villous ultrastructure structure and immunohistochemistry in order to determine the likely origin of fetal hypoxia in this condition. "
04/21/1957 - "[Contribution to the study of fetal anoxia; determination of oxygen in the blood of the umbilical vessels at the time of birth; study of the functional results of neo-natal pathology & the clinical details of pregnancy & labor; analysis of 114 personal cases]."
04/14/1957 - "[Contribution to the study of fetal anoxia; determination of oxygen in the blood of the umbilical vessels at the time of birth; study of the results as a function of neo-natal pathology & the clinical details of pregnancy & labor; analysis of 114 personal cases]."

02/01/2014 - "The time between onset of fetal hypoxia and first appearance of nucleated red blood cells (NRBCs) in the blood can conceptually be divided into two periods; (1) the 'erythropoietin (EPO) generation time', which previous fetal studies suggest is 4 to 5 h, and (2) the 'NRBC emergence time'. "
10/01/2004 - "In this study we investigated whether chronic fetal hypoxia, as indicated by amniotic fluid erythropoietin levels, is associated with perinatal morbidity in type 1 diabetic pregnancies. "
11/01/1994 - "From this study, we found that the mechanism of increased erythropoietin levels in neonates can be different from fetal hypoxia. "
01/01/2021 - "All OT1D had amniotic fluid (AF) sampled for erythropoietin (EPO) measurement within two days before delivery in order to diagnose fetal hypoxia. "
03/01/2015 - "High amniotic fluid erythropoietin concentration reflects chronic fetal hypoxia. "

06/01/2005 - "This study investigates the validity of transabdominal pulse oximetry using a sheep fetal hypoxia model with fetal arterial hemoglobin saturation. "
07/01/1956 - " I. Behavior of hemoglobin and of erythrocytes in acute fetal anoxia in rats]."
07/30/2017 - "Using a rat model, the present study demonstrated that a simple treatment using hemoglobin vesicles for placental ischemia rescues placental and fetal hypoxia, leading to appropriate fetal growth. "
12/01/2008 - "These results suggest that meconium passage may not be associated with chronic fetal hypoxia as demonstrated by similar red blood cell count, total hemoglobin values and fetal hemoglobin (HbF) and adult hemoglobin (HbA) contents."
05/01/1996 - "Significant changes in fetal iron status potentially occur in pregnancies in which reduced fetal nutrient delivery is severe enough to result in intrauterine growth retardation (IUGR), particularly if chronic fetal hypoxia is also present and increases fetal iron demand for hemoglobin synthesis. "

12/20/2018 - "This ex utero fetal support system has potential to become a significant research tool and novel therapy to correct fetal hypoxia."
12/20/2018 - "No therapies exist to correct fetal hypoxia. "
01/01/1995 - "Metabolic therapy brought about a twofold reduction of the incidence of fetal hypoxia and hypotrophy."
11/01/1955 - "[Intramedial glycide therapy in fetal hypoxia]."
03/01/1989 - "For this reason, it is proposed to expand indications for metabolic therapy and hyperbaric oxygenation in order to prevent intrauterine chronic fetal hypoxia."

01/01/2009 - "In the light of the results of the study the authors recommend monitoring the fetal status using intrapartum fetal pulse oximetry in cases of non-reassuring or pathological cardiotocography, which allows a significant reduction in the Caesarean section rate for an imminent fetal hypoxia (Tab. "
02/01/2023 - "Fetal cord arterial blood pH is an objective method to diagnose intrapartum fetal hypoxia, hence by observing the incidence of acidemia in cord blood pH among those newborns born through cesarean section (CS) in view of non-reassuring CTG can help make a judicious decision. "
01/01/2022 - "The threat of intrauterine fetal hypoxia increases during natural childbirth and decreases during caesarean section. "
07/01/2012 - "We conclude that intrapartum fetal Doppler velocimetry, when combined with CTG, increases the clinicians' ability to accurately identify fetal hypoxia, and decreases the rate of Cesarean section."
02/01/2009 - "Amniotic fluid samples in 35 pregnancies at high risk for chronic fetal hypoxia were obtained at cesarean section or by amniocentesis done within a median of 2 days before delivery. "

08/25/2010 - "However, in many of the animal studies nicotine has been administered by subcutaneous injections, which could lead to significant fetal hypoxia; some routes of drug administration included stressful procedures to pregnant dams that could create unfavorable fetal environment. "

01/01/2006 - "To detect fetal hypoxia and the effects of anesthesia on fetal hemodynamics, the fetal heart rate (FHR) was monitored using a fetal Doppler ultrasonography unit fixed to the mother's abdominal wall. "
03/01/1986 - "[Evaluation of the types of anesthesia for labor in parturients with chronic fetal hypoxia]."
04/01/1955 - "[Fetal anoxia and anesthesia in cesarean section]."
12/01/2021 - "Maternal safety and avoidance of fetal hypoxia and subsequent preterm labor are crucial when pregnant patients receive anesthesia. "
09/15/1976 - "Based on these observations and after brief review of some hypotheses advanced to explain post-paracervical anesthesia fetal bradycardia, it is postulated that this bradycardia is probably due to uterine artery spasm, causing decreased intervillous space blood flow and fetal hypoxia."

01/10/2019 - "We investigated histology and gene expression in the postnatal rat ovary after fetal hypoxia induced by uterine artery ligation. "
09/22/2009 - "A unilateral ligation of the uterine artery in pregnant rat at the embryonic day 17 induces fetal hypoxia and subsequent growth restriction (GR) in neonatal pups. "
03/23/2001 - "We therefore caused uteroplacental insufficiency and growth retardation by performing bilateral uterine artery ligation upon pregnant rats 2 days prior to term delivery and elicited further perinatal fetal hypoxia by placing maternal rats in 14% FiO(2) 3 h prior to delivery. "
01/01/2006 - "Chronic fetal hypoxia and IUGR were experimentally induced by single umbilical artery ligation (SUAL) in catheterised fetal sheep. "
01/01/2011 - "Anti-inflammatory therapy in an ovine model of fetal hypoxia induced by single umbilical artery ligation."