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Ferrochelatase (Heme Synthetase)

A mitochondrial enzyme found in a wide variety of cells and tissues. It is the final enzyme in the 8-enzyme biosynthetic pathway of HEME. Ferrochelatase catalyzes ferrous insertion into protoporphyrin IX to form protoheme or heme. Deficiency in this enzyme results in ERYTHROPOIETIC PROTOPORPHYRIA.
Also Known As:
Heme Synthetase; Protoheme Ferro-Lyase; Zinc Chelatase; Chelatase, Porphyrin-Metal; Chelatase, Zinc; Ferro-Lyase, Protoheme; Porphyrin Metal Chelatase; Protoheme Ferro Lyase; Synthetase, Heme; Porphyrin-Metal Chelatase
Networked: 311 relevant articles (1 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Gouya, Laurent: 9 articles (11/2019 - 01/2002)
2. Minder, Elisabeth I: 8 articles (01/2020 - 05/2003)
3. Schneider-Yin, Xiaoye: 8 articles (01/2020 - 05/2003)
4. Deybach, Jean-Charles: 8 articles (01/2019 - 01/2002)
5. Taketani, Shigeru: 8 articles (01/2013 - 05/2002)
6. Schneider-Yin, X: 7 articles (11/2010 - 08/2000)
7. Di Pierro, Elena: 6 articles (03/2022 - 05/2005)
8. Nakano, Hajime: 6 articles (01/2022 - 12/2006)
9. Puy, Hervé: 6 articles (11/2019 - 02/2004)
10. Bloomer, Joseph R: 6 articles (07/2011 - 06/2002)

Related Diseases

1. Colonic Neoplasms (Colon Cancer)
2. Erythropoietic Protoporphyria
3. Neoplasms (Cancer)
4. Porphyrias (Porphyria)
5. Carcinoma (Carcinomatosis)

Related Drugs and Biologics

1. Long Noncoding RNA
2. protoporphyrin IX
3. Heme (Haem)
4. Enzymes
5. Iron
6. Messenger RNA (mRNA)
7. Acids
8. 1-phenyl-3,3-dimethyltriazene (PDT)
9. Griseofulvin (Grifulvin V)
10. Transferrin Receptors (Transferrin Receptor)

Related Therapies and Procedures

1. Photochemotherapy (Photodynamic Therapy)
2. Precision Medicine
3. Microbubbles
4. Bone Marrow Transplantation (Transplantation, Bone Marrow)