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Felty's Syndrome (Syndrome, Felty's)

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A combination of rheumatoid arthritis, splenomegaly, leukopenia, pigmented spots on lower extremities, and other evidence of hypersplenism (anemia and thrombocytopenia). (From Dorland, 27th ed)

Also Known As:

Syndrome, Felty's; Familial Felty's Syndrome; Rheumatoid Arthritis, Splenomegaly and Neutropenia; Familial Felty Syndrome; Familial Feltys Syndrome; Felty Syndrome; Felty's Syndrome, Familial; Feltys Syndrome; Syndrome, Familial Felty's

Networked: 282 relevant articles (20 outcomes, 14 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neutropenia
2.	Infection
3.	Rheumatoid Arthritis
4.	Systemic Lupus Erythematosus (Libman-Sacks Disease)
5.	Agranulocytosis (Granulocytopenia)

Experts

1.	Radic, Marko: 3 articles (10/2015 - 04/2012)
2.	Hellmich, Bernhard: 3 articles (04/2012 - 08/2002)
3.	Csernok, Elena: 3 articles (04/2012 - 08/2002)
4.	Dwivedi, Nishant: 2 articles (03/2014 - 04/2012)
5.	Hellmich, B: 2 articles (02/2005 - 07/2004)
6.	Coakley, G: 2 articles (07/2004 - 04/2000)
7.	Gross, Wolfgang L: 2 articles (09/2002 - 08/2002)
8.	Schatz, Helmut: 2 articles (09/2002 - 08/2002)
9.	Schnabel, Armin: 2 articles (09/2002 - 08/2002)
10.	Muller, Sylviane: 1 article (10/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Felty's Syndrome:

1.	rituximab (Mabthera)FDA Link 07/01/2008 - "To our knowledge, only one previous case of rituximab being beneficial in the treatment of Felty's syndrome has been reported. " 07/01/2008 - "Rituximab is useful in the treatment of Felty's syndrome." 10/01/2008 - "Efficacy of rituximab in Felty's syndrome." 09/01/2008 - "Efficacy of rituximab in Felty's syndrome." 02/01/2005 - "Lack of efficacy of rituximab in Felty's syndrome."
2.	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 05/01/1997 - "Long-term use of G-CSF appears well tolerated and effective in Felty's syndrome. " 01/01/1998 - "Treatment of Felty's syndrome with the haemopoietic growth factor granulocyte colony-stimulating factor (G-CSF)." 11/01/1997 - "The use of granulocyte colony-stimulating factor in joint replacement surgery in a patient with Felty's syndrome." 03/01/1995 - "A 58-year-old white male with Felty's syndrome was successfully treated with granulocyte colony stimulating factor (GCSF). " 01/01/1995 - "A prolonged use of granulocyte colony stimulating factor in Felty's syndrome."
3.	Immunoglobulin G (IgG)IBA 09/01/1992 - "In eight of 10 assessed sera from patients with Felty's syndrome eluted IgG decreased from elevated to normal levels. " 01/01/1987 - "It is concluded that neutrophil reactive IgG may have an important role in both quantitative and qualitative defects in neutrophil function in Felty's syndrome." 01/01/1987 - "In addition, serum levels of IgG polymorphonuclear leucocyte binding activity (IgG PBA) were also raised in the group with Felty's syndrome. " 02/01/1984 - "In contrast, small cytoplasmic inclusions were found both in Felty's syndrome and RA patients and in some of the controls, and IgG and C3 were the most frequent constituents in these cases. " 02/01/1980 - "A strong correlation was observed between the levels of direct neutrophil-bound IgG and the serum IgG neutrophil-binding activity for the seventeen patients with Felty's syndrome. "
4.	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 05/01/1991 - "We now describe the second trial of recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF), in a splenectomized, infected patient with Felty syndrome." 06/01/1995 - "Sustained response in Felty's syndrome to prolonged administration of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF)." 01/01/1992 - "Felty's syndrome: favorable response to granulocyte-macrophage colony-stimulating factor in the acute phase." 05/01/1991 - "GM-CSF in the treatment of Felty syndrome." 01/01/1994 - "Long-term remission of neutropenia in Felty's syndrome after a short GM-CSF treatment."
5.	GoldIBA 06/30/1986 - "[Efficacy of therapy with triethylphosphine gold in a case of Felty's syndrome]." 01/01/2005 - "To evaluate the incidence, complications, and course of Felty's syndrome (FS) in patients treated with intramuscular (IM) gold. " 01/01/2005 - "Longterm outcome of treatment of Felty's syndrome with intramuscular gold: case reports and recommendations for management." 03/01/1986 - "Parenteral gold therapy in the Felty syndrome. " 11/01/1981 - "Felty's syndrome: response to parenteral gold."
6.	AntibodiesIBA 08/01/2000 - "Screening of a large panel of sera revealed that 66% of patients with Felty's syndrome had elevated levels of anti-eEF1A-1 antibodies. " 10/01/1984 - "In 7 patients with classical Felty's syndrome there was no increase of UCHT4 cells in the blood and the large majority of T cells stained with OKT1-like antibodies. " 04/01/1974 - "White-cell antibodies and the aetiology of Felty's syndrome." 01/01/1988 - "Sera of 22 patients with Felty's syndrome and 14 patients with rheumatoid arthritis were tested in assays routinely used for the detection of neutrophil antibodies (i.e. " 02/01/2004 - "In RA complicated by extraarticular manifestations, anti-GPI antibodies were observed in 18% of patients with rheumatoid nodules, 45% of patients with rheumatoid vasculitis, and 92% of patients with Felty's syndrome. "
7.	LithiumIBA 06/11/1988 - "[Low doses of lithium in Felty's syndrome]." 05/01/1982 - "Utilizing lithium in a patient with Felty's syndrome." 08/28/1976 - "[Letter: Treatment of Felty's syndrome by lithium]." 03/01/1976 - "Letter: Lithium in Felty's syndrome." 11/01/1977 - "Reduction of infections in Felty's syndrome through use of lithium."
8.	Penicillamine (Cuprimine)FDA Link 08/01/1985 - "Although D-penicillamine is effective in treatment of Felty's syndrome, its side effects can be serious and potentially lethal. " 08/01/1985 - "We report our experience with 8 patients with Felty's syndrome who were treated with D-penicillamine for a mean of one year. " 08/01/1985 - "D-penicillamine in Felty's syndrome." 12/30/1983 - "Conditions often associated with rheumatoid arthritis and also thought to have an immunologic basis, such as Sjögren's syndrome, Felty's syndrome, and rheumatoid vasculitis, and reactions to medications, such as gold and penicillamine, reveal an interesting spectrum of immunogenetic relationships. " 09/01/1977 - "It is proposed, therefore, that therapy in Felty's syndrome be directed at the underlying disease process, and gold salts and penicillamine should be considered for this purpose. "
9.	DNA (Deoxyribonucleic Acid)IBA 03/01/1992 - "Specific autoantibody identification, where possible, was usually of SS-A or SS-B although two sera from patients with Felty's syndrome had low levels of DNA antibody. " 01/01/1990 - "The 2.65-kb C2 DNA allele showed allelic association with HLA-B44 and C4BQ0 and may help to further characterize the haplotype B44-BfS-C4A3-C4BQ0-DR4, which has previously been described in Felty's syndrome." 06/01/1986 - "Southern blot analysis with DR beta and DQ beta cDNA probes was used to compare genomic DNA from Felty's syndrome patients with HLA-DR-matched normal controls. "
10.	Auranofin (Ridaura)FDA Link 09/01/1987 - "Five patients who had Felty's syndrome were treated with auranofin, 6 mg/day, for a period that ranged from 4 months to 2 years. " 04/01/1983 - "Felty's syndrome: response to auranofin." 09/01/1987 - "Felty's syndrome: long-term followup after treatment with auranofin." 09/01/1987 - "Auranofin appears to be an effective treatment for Felty's syndrome, and to have a lower degree of toxicity than parenteral gold." 09/01/1989 - "Treatment of Felty's syndrome with auranofin and methylprednisolone."

Therapies and Procedures

1.	Splenectomy 12/01/1952 - "[Clinical and anatomo-pathological study of a case of Felty's syndrome with splenectomy]." 04/01/2004 - "The risk of hospitalization for splenectomy in Felty's syndrome was 71% lower in 1998-2001 than in 1983-1987. " 05/01/1998 - "Thus, there is evidence for feedback control of the white cell count in Felty's syndrome after splenectomy." 05/01/1998 - "Feedback control of the white blood cell (WBC) count was analyzed in 20 cases reported by Coon, before and after splenectomy in Felty's syndrome. " 05/01/1998 - "Possible feedback control of white blood cells: effect of splenectomy in Felty's syndrome."
2.	Plasmapheresis 02/01/1989 - "[A case of antigranulocyte antibody positive Felty's syndrome and its efficacy of plasmapheresis]." 01/01/1985 - "Plasmapheresis in Felty's syndrome."
3.	Drug Therapy (Chemotherapy) 09/01/1981 - "A 61-yr-old white man with Felty's syndrome, who had previously undergone splenectomy, presented for cytotoxic chemotherapy. " 08/01/1997 - "They have been used primarily by rheumatologists to treat neutropenia accompanying infections in patients with Felty's syndrome or systemic lupus erythematosus and in infected patients made neutropenic with drug therapy. " 01/01/1984 - "Other encouraging reports include the effect of lithium to induce leucocytosis in Felty's syndrome and chemotherapy-induced neutropenia." 09/01/1981 - "Cytotoxic chemotherapy for cancer in Felty's syndrome: role of lithium carbonate." 01/01/1984 - "These are: hyperthyroidism, metabolizing thyroid cancer, syndrome of inappropriate secretion of antidiuretic hormone, premenstrual tension syndrome, anorexia nervosa, Felty's syndrome, chemotherapy-induced neutropenia, aplastic anemia, seborrheic dermatitis, eczematoid dermatitis, cyclic vomiting, diabetes mellitus and asthma. "
4.	Arthroplasty 07/01/1992 - "Splenectomy as treatment for nonhealing soft tissue defect after total knee arthroplasty in a patient with Felty's syndrome." 04/01/2004 - "Rates of hospitalization for rheumatoid vasculitis and splenectomy in Felty's syndrome have decreased over the past 19 years, and there has been a recent decrease in the rates of primary total knee arthroplasty in patients with RA. " 04/01/2004 - "Data on all patients with RA who were hospitalized with rheumatoid vasculitis or to undergo splenectomy for Felty's syndrome, cervical spine fusion for myelopathy, or total knee arthroplasty at hospitals in California were abstracted from a state hospitalization database. "
5.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 01/01/1994 - "Samples were obtained from patients with a range of clinical conditions including primary adult autoimmune neutropenia, autoimmune neutropenia of infancy, autoimmune neutropenia secondary to Felty's syndrome, rheumatoid arthritis, idiopathic thrombocytopenic purpura, systemic lupus erythematosus, proliferative disorders, bone marrow transplantation and patients with documented febrile or pulmonary transfusion reactions. "