Volatile Fatty Acids

Short-chain fatty acids of up to six carbon atoms in length. They are the major end products of microbial fermentation in the ruminant digestive tract and have also been implicated in the causation of neurological diseases in humans.

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Networked: 513 relevant articles (18 outcomes, 72 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Andoh, Akira: 8 articles (07/2011 - 01/2002)
2.	Araki, Yoshio: 7 articles (01/2011 - 01/2002)
3.	Fujiyama, Yoshihide: 7 articles (01/2011 - 01/2002)
4.	Ardatskaia, M D: 6 articles (01/2014 - 01/2001)
5.	Nyman, Margareta: 5 articles (09/2015 - 01/2013)
6.	MacFabe, Derrick F: 4 articles (01/2015 - 01/2007)
7.	Minushkin, O N: 4 articles (01/2014 - 01/2001)
8.	Takizawa, Wataru: 4 articles (04/2004 - 01/2002)
9.	Takizawa, Jyou: 4 articles (04/2004 - 01/2002)
10.	Bamba, Tadao: 4 articles (01/2003 - 01/2002)

Related Diseases

1.	Colitis 05/01/2014 - "The aim of this study was to evaluate the effects of short- and long-term Passiflora edulis peel intake on the antioxidant status, microbiota, and short-chain fatty acids formation in rats with 2,4,6-trinitrobenzenesulphonic acid-induced colitis using two "in vivo" experiments: chronic (prevention) and acute (treatment). " 09/01/2000 - "In this study, we investigated the roles of the intestinal microflora and short chain fatty acids (SCFAs) following administration of GBF in DSS-induced rat colitis. " 11/01/1995 - "The aim of the study was to evaluate the effectiveness of short chain fatty acids on microbial flora of patients with diversion colitis and to compare this flora to the microbial flora of controls. " 08/02/2013 - "We determined that short-chain fatty acids, gut microbiota-derived bacterial fermentation products, regulate the size and function of the colonic Treg pool and protect against colitis in a Ffar2-dependent manner in mice. " 05/01/2002 - "Short-chain fatty acids (SCFAs), which remain poorly documented in experimental colitis, were also investigated. "
2.	Ulcerative Colitis 10/01/2015 - "The use of short chain fatty acids to modulate gastrointestinal inflammatory conditions such as ulcerative colitis has produced encouraging results either in animal models or also in clinical trials. " 11/01/1996 - "This study showed trends towards a beneficial effect of topical short-chain fatty acids in active ulcerative colitis, but more patients are needed to demonstrate this effect with sufficient statistical power." 01/01/2010 - "to determine the fecal excretion of short-chain fatty acids (SCFA) in patients with active ulcerative colitis (UC) depending on the duration, activity, and severity of the disease. " 01/01/2010 - "[Fecal excretion of short-chain fatty acids as a marker of the severity of ulcerative colitis]." 01/01/2005 - "[Role of short-chain fatty acids in the pathogenesis and therapy of ulcerative colitis]."
3.	Neoplasms (Cancer) 08/01/2012 - "A significant reduction in cell proliferation in colonic crypts and tumors and short chain fatty acids (SCFA) caecal contents was observed in the groups orally treated with 1.0% yacon (G3) or the synbiotic formulation (G4). " 01/01/2014 - "This is consistent with difference in properties of the cells under study, such as expression of the TP53 tumor suppressor, or the transporter for short-chain fatty acids, SLC5A8." 01/25/1999 - "The fermentation of wheat fiber to short-chain fatty acids--especially butyric, which has been shown to inhibit tumor growth in vitro--is documented, but interpretation of the data from animal studies and clinical trials is subject to debate. " 07/01/1999 - "Thirty-three weeks after the initial injection, the mice were sacrificed, examined for tumors, and the cecal contents were analyzed to determine the moisture content and the concentrations of short-chain fatty acids (SCFA). " 02/01/1999 - "Beside their role as the main energy source in the colonic mucosa, short chain fatty acids were found to act as potent antiproliferative and differentiation agents in various cancer cell lines. "
4.	Inflammation 09/01/2015 - "The aim of the study was to investigate how four barley malts, caramelized and colored malts, 50-malt and 350-malt, differing in functional characteristics concerning beta-glucan content and color, affect short-chain fatty acids (SCFA), barrier function and inflammation in the hindgut of rats fed high-fat diets. " 01/01/2015 - "In addition, short-chain fatty acids in breast milk activate receptors on T-reg cells and bacterial genes, which preferentially mediate intestinal tight junction expression and anti-inflammation. " 12/01/2014 - "Gut microbiota-derived short-chain Fatty acids, T cells, and inflammation." 11/04/2014 - "The low-MAC Western diet results in poor production of gut microbiota-generated short-chain fatty acids (SCFAs), which attenuate inflammation through a variety of mechanisms in mouse models. " 01/01/2014 - "For example, it has been suggested that gut microbiota-derived short-chain fatty acids absorbed in the blood play a role in regulation of systemic inflammation by inducing apoptosis of neutrophils as well as chemotaxis of regulatory T cells."
5.	Diarrhea 01/01/2015 - "The aim of this study was to evaluate the fecal microbiome, fecal concentrations of short-chain fatty acids (SCFAs), as well as serum and urine metabolites in healthy dogs (n=13) and dogs with acute diarrhea (n=13). " 04/01/1994 - " Studies with their corresponding findings have continued since then, with current efforts focused upon developing a treatment for diarrhea using the role of short chain fatty acids in acute watery diarrhea." 09/01/2013 - "Fiber-enriched formula can reduce the incidence of diarrhea and produce short-chain fatty acids for colonocytes. " 07/01/2013 - "coli virulence genes by OA could make the combination of short chain fatty acids and MCFA as interesting gut flora modifiers, which can eventually prevent postweaning diarrhea. " 09/01/2007 - "Lactobacillus plantarum 299v enhances the concentrations of fecal short-chain fatty acids in patients with recurrent clostridium difficile-associated diarrhea."

Related Drugs and Biologics

1.	Butyrates (Butyrate)
2.	Glucose (Dextrose)
3.	Glutamine (L-Glutamine)
4.	Prebiotics
5.	Starch (Cornstarch)
6.	Phenobarbital (Luminal)
7.	Proteins (Proteins, Gene)
8.	Messenger RNA (mRNA)
9.	Nitric Oxide (Nitrogen Monoxide)
10.	Lipase (Acid Lipase)

Related Therapies and Procedures

1.	Enema (Enemas)
2.	Total Parenteral Nutrition
3.	Catheters
4.	Oral Administration
5.	Enteral Nutrition (Feeding, Tube)