Nonesterified Fatty Acids (NEFA)

01/01/2006 - "RSG + SU significantly decreased HbA(1c), FPG, insulin resistance, plasma free fatty acids and medical care utilization and improved treatment satisfaction compared with uptitrated SU. "
11/01/2015 - "We therefore designed this study to test the hypothesis that elevated nocturnal NEFA are an early signal for hyperinsulinaemic compensation for insulin resistance. "
09/01/2013 - "The objective of this study was to describe longitudinal relations of serum total free fatty acids (FFAs) to insulin resistance (IR) and cardiovascular (CV) risk factors from adolescence into adulthood. "
06/01/2013 - "This study tested whether GSH deficiency in aging contributes to impaired mitochondrial NEFA oxidation and insulin resistance, and whether GSH restoration reverses these defects. "
05/01/2013 - "This study tested whether increases in visceral adiposity, adipocyte size, and total free fatty acids underlie the insulin resistance seen in prenatal T-treated female sheep. "

01/01/1990 - "In this study, GH (50 micrograms/kg/day) increased growth rate, body weight, pectoralis (breast) muscle weight, adipose tissue weight, bursa Fabricius weight and the plasma concentrations of free fatty acids. "
07/01/2015 - "5-CQA suppressed HFD-induced increases in body weight and visceral fat-pad weight, serum lipid levels, and serum and hepatic free fatty acids in a dose-dependent manner. "
12/30/2014 - "Egg production was negatively correlated to body weight, fractional abdominal fat weight and plasma NEFA concentrations in AL hens (P<0.05). "
01/01/2014 - "Body weight, visceral fat, plasma free fatty acids (FFAs), plasma triglyceride and ACR levels increased significantly in the obese rats (P < 0.01). "
01/01/2014 - "Sprague Dawley rats weighing 150-200 g were divided into six groups, viz; group C; was treated as a negative control and fed with standard rodents chow, group H; was treated as a positive control and fed with an experimental diet enriched with saturated free fatty acids for 8 weeks, groups HP0.5, HP1 and HP2 which were fed with 0.5,1 and 2 g/kg (body weight) /day of POLE orally during the last 24 days of the high fat diet feeding period and group P; fed with highest dose of POLE. "

04/01/2015 - "Thus, the SCFAs might contribute to healthier adipocytes and subsequently also to improved energy metabolism with for example less circulating free fatty acids, which is beneficial in the context of obesity and type 2 diabetes. "
06/01/2009 - "Given the unique susceptibility of pancreatic beta cells to free fatty acids in FH(+) subjects, interventions that protect against obesity-induced lipotoxicity may hold the greatest promise for preventing T2DM in genetically predisposed individuals."
10/01/2015 - "To better understand the associations of free fatty acids (FFAs) with metabolic phenotypes of obesity, we applied a targeted metabolomics approach to measure 40 serum FFAs from 452 individuals who participated in four independent studies, using an ultra-performance liquid chromatograph coupled to a Xevo G2 quadruple time-of-flight mass spectrometer. "
12/01/2014 - "To study how long-term elevated non-esterified fatty acid (NEFA) concentrations, typical in metabolic disorders such as obesity or type 2 diabetes, affect murine follicular development, follicle quality, and subsequent oocyte developmental competence in vitro. "
11/01/2004 - "Experimental studies show that circulating free fatty acids (FFAs) promote the secretory activity of the HPA axis and that human obesity is associated with high circulating FFAs. "

11/15/2010 - "Compound 18l significantly suppressed weight gain and significantly improved blood parameters such as TG, total cholesterol and NEFA without overt toxic effects."
11/01/2009 - "This compound also significantly suppressed weight gain and significantly improved blood parameters such as TG, total cholesterol and NEFA. "
06/01/1991 - "A lower metabolic rate was a determinant of future weight gain, and abnormalities in use of free fatty acids and cell insulin action were suggested, which emphasize the need for further studies in these areas."
05/01/2012 - "In conclusion, feeding 30% more feed from day 3 till d 35 of second gestation increased weight gain and resulted in lower NEFA concentrations, but did not affect progesterone, LH or IGF-1 and embryonic and placental characteristics."
04/27/2011 - "In the animal study, weight gains, insulin resistance index, plasma triglyceride (TG), nonesterified fatty acid (NEFA), and cholesterol levels in the 40 mg/kg of CA-administered group were significantly decreased by 67.3, 55, 39, 31, and 23%, respectively, when compared to the high-fat diet control group. "

11/01/2011 - "Thus, FO improved liver TAG and NEFA levels compared with weight loss on the control diet. "
01/01/2015 - "The data demonstrate that weight loss caused by VLCD does not affect abdominal fasting NEFA uptake rates. "
10/28/2014 - "During the weight-loss period, TAG and NEFA concentrations were highest in the RAPID group, as were α-tocopherol and ferric-reducing ability of plasma concentrations. "
11/01/2011 - "However, weight loss on the control-fat diet caused significant increase in hepatic and cardiac NEFA. "
11/01/2011 - "Fish oil combined with SCFA synergistically prevent tissue accumulation of NEFA during weight loss in obese mice."