Fasciitis (Fascitis)

Inflammation of the fascia. There are three major types: 1, Eosinophilic fasciitis, an inflammatory reaction with eosinophilia, producing hard thickened skin with an orange-peel configuration suggestive of scleroderma and considered by some a variant of scleroderma; 2, Necrotizing fasciitis (FASCIITIS, NECROTIZING), a serious fulminating infection (usually by a beta hemolytic streptococcus) causing extensive necrosis of superficial fascia; 3, Nodular/Pseudosarcomatous /Proliferative fasciitis, characterized by a rapid growth of fibroblasts with mononuclear inflammatory cells and proliferating capillaries in soft tissue, often the forearm; it is not malignant but is sometimes mistaken for fibrosarcoma.

Also Known As:

Networked: 512 relevant articles (15 outcomes, 16 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Myositis (Idiopathic Inflammatory Myopathies)
2.	Eosinophilia
3.	Arthritis (Polyarthritis)
4.	Septic Shock (Toxic Shock Syndrome)
5.	Panniculitis

Experts

1.	Fletcher, Christopher D M: 3 articles (10/2008 - 06/2002)
2.	Yamane, K: 3 articles (08/2004 - 09/2000)
3.	Nashel, Jennifer: 2 articles (08/2015 - 02/2012)
4.	Steen, Virginia: 2 articles (08/2015 - 02/2012)
5.	Kim, S W: 2 articles (06/2015 - 02/2014)
6.	Nather, Aziz: 2 articles (01/2015 - 05/2010)
7.	Jinnin, Masatoshi: 2 articles (08/2014 - 12/2003)
8.	Asano, Yoshihide: 2 articles (08/2014 - 12/2003)
9.	Tamaki, Kunihiko: 2 articles (08/2014 - 12/2003)
10.	Ihn, Hironobu: 2 articles (08/2014 - 12/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Fasciitis:

1.	Cyclosporine (Ciclosporin)FDA LinkGeneric 11/01/2005 - "Eosinophilic fasciitis successfully treated with cyclosporine." 02/01/1997 - "Eosinophilic fasciitis with myelodysplasia responsive to treatment with cyclosporin." 09/01/2008 - "Long-term remission by cyclosporine in a patient with eosinophilic fasciitis associated with primary biliary cirrhosis." 02/01/1992 - "Cyclosporin A induced remission of CD4+ T-CLL associated with eosinophilia and fasciitis." 02/01/2003 - "The patient was treated with cyclosporine and prednisone, which resulted in much improvement of her symptoms and signs related to the fasciitis. "
2.	infliximab (Remicade)FDA Link 06/01/2010 - "Infliximab may be effective in the treatment of steroid-resistant eosinophilic fasciitis: report of three cases." 06/01/2008 - "Infliximab effective in steroid-dependent juvenile eosinophilic fasciitis." 04/01/2007 - "A 39-year-old woman was treated with infliximab for corticoid-dependent Shulman fasciitis. " 04/01/2007 - "We report a new case involving infliximab used to treat Shulman fasciitis. " 05/01/2011 - "Eosinophilic fasciitis mimicking angioedema and treatment response to infliximab in a pediatric patient."
3.	Prednisolone (Predate)FDA LinkGeneric 12/01/2010 - "A diagnosis of eosinophilic fasciitis was confirmed and the patient received prednisolone. " 03/01/2011 - "Prednisolone was effective in treating both gastroenteritis and fasciitis." 01/01/2008 - "Therapeutic efficacy of intravenous cyclophosphamide concomitant with moderate- to high-dose prednisolone in two patients with fasciitis panniculitis syndrome."
4.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 02/01/2008 - "Anti-neutrophil cytoplasmic antibody (c-ANCA) positive recurrent eosinophilic fasciitis responsive to cyclophosphamide: a clinical pathology conference held by the Division of Rheumatology at Hospital for Special Surgery." 01/01/2008 - "Therapeutic efficacy of intravenous cyclophosphamide concomitant with moderate- to high-dose prednisolone in two patients with fasciitis panniculitis syndrome." 01/01/1991 - "A 54 year old woman presented with an intra-abdominal adenocarcinoma of primary coelomic origin and a syndrome of palmar fasciitis and arthritis, which was exacerbated during treatment by combination chemotherapy with intravenous carboplatin 300 mg/m2 and cyclophosphamide 750 mg/m2, while the tumour responded well."
5.	Tryptophan (L-Tryptophan)FDA Link 03/01/2008 - "This case of noneosinophilic fasciitis associated with ingestion of L-tryptophan-containing protein supplement responded favorably to corticosteroid therapy. " 05/01/1991 - "Study of 18 biopsy specimens in 11 patients with L-tryptophan-related eosinophiliamyalgia (fasciitis) syndrome showed hyaline sclerodermoid changes. " 01/01/1991 - "Additional studies are warranted to determine the prevalence of L-tryptophan ingestion among patients diagnosed as having eosinophilic fasciitis." 01/01/2010 - "Eosinophilic fasciitis has been linked to certain drugs and chemicals, notably L-tryptophan ingestion and the statin family of drugs." 06/01/2006 - "It is unknown whether these products of tryptophan metabolism play a role in the pathogenesis of this syndrome and the closely related condition of eosinophilic fasciitis. "
6.	Prednisone (Sone)FDA LinkGeneric 10/01/1989 - "Treatment with moderate dosages of prednisone resulted in a prompt and complete remission of both the fasciitis and the selective marrow aplasia." 10/01/1986 - "A 2-year 10-month old girl developed eosinophilic fasciitis that resolved within one year after the administration of prednisone. " 11/01/1999 - "Favorable response of the eosinophilic fasciitis to prednisone therapy was attained in 3 of 3 patients with reactive lymphadenopathy and in 4 of the 6 cases with lymphoma. " 10/01/1977 - "The main signs are the acute painful onset after an unusual physical exertion, the development of fasciitis, and (or) myositis, and (or) scleroderma of limbs, the absence of Raynaud's phenomenon, visceral involvement, constant eosinophilia and hypergammaglobulinemia; the prognosis is good with an improvement sometimes spontaneous or coincident with prednisone therapy. " 02/01/2003 - "The patient was treated with cyclosporine and prednisone, which resulted in much improvement of her symptoms and signs related to the fasciitis. "
7.	CytokinesIBA 03/01/1999 - "The superantigens produce an excessive stimulation of the immune system, with a subsequent outpouring of inflammatory cytokines causing the multiorgan failure that characterises both streptococcal necrotising fasciitis as well as streptococcal toxic shock syndrome. " 12/01/1999 - "Because tissue damage in streptococcal and post-streptococcal sequelae might be the end result of a distinct synergism between streptococcal and host-derived proinflammatory agonists it is proposed that only cocktails of anti-inflammatory agents including distinct inhibitors of SLS (phospholipids), gamma globulin, inhibitors of reactive oxygen species, proteinases, cationic proteins cytokines etc., will be effective in inhibiting the multiple synergistic interactions which lead to fasciitis, myositis and the flesh-eating syndromes, and often develop into sepsis, septic shock and multiple organ failure. "
8.	Carboplatin (JM8)FDA LinkGeneric 04/01/2006 - "[Palmar fasciitis after carboplatin administration for an ovarian adenocarcinoma]." 01/01/1991 - "A 54 year old woman presented with an intra-abdominal adenocarcinoma of primary coelomic origin and a syndrome of palmar fasciitis and arthritis, which was exacerbated during treatment by combination chemotherapy with intravenous carboplatin 300 mg/m2 and cyclophosphamide 750 mg/m2, while the tumour responded well."
9.	tocilizumabFDA Link 12/01/2015 - "Efficacy of Tocilizumab in the treatment of Eosinophilic fasciitis: Report of one case." 03/01/2015 - "Development of necrotising fasciitis in a patient treated for rheumatoid arthritis with tocilizumab."
10.	imatinib (Gleevec)FDA Link 01/01/2012 - "Imatinib is effective for prevention and improvement of fibrotic fasciitis as a manifestation of chronic GVHD." 09/01/2005 - "Concomitant eosinophilia, fasciitis, and mycosis fungoides-like reaction with antinuclear autoantibodies in chronic myeloid leukaemia: role of a T-cell clone induced by imatinib."

Therapies and Procedures

1.	Combination Drug Therapy (Combination Chemotherapy) 01/01/1991 - "A 54 year old woman presented with an intra-abdominal adenocarcinoma of primary coelomic origin and a syndrome of palmar fasciitis and arthritis, which was exacerbated during treatment by combination chemotherapy with intravenous carboplatin 300 mg/m2 and cyclophosphamide 750 mg/m2, while the tumour responded well."
2.	Activities of Daily Living (ADL) 06/01/1997 - "The recovery was much sooner than in previously reported cases treated conservatively, suggesting that surgical management of eosinophilic fasciitis is effective in alleviating symptoms quickly and allows patients to resume activities of daily living sooner."
3.	Debridement 01/01/2015 - "Infection control, early surgical debridement, and antibiotic therapy are now the central tenets of the clinical management of necrotising fasciitis; these treatment approaches all originate from those used in wars in the past 150 years. " 03/01/2013 - "We present the case of a patient who was admitted to Recovery room after surgical debridement due to suspicion of fasciitis. " 03/01/2013 - "We describe three patients who were referred from other units several weeks after developing periocular necrotising fasciitis; in all the three, the disease had been managed medically without surgical debridement, with apparent 'stalling' of the inflammatory process despite persistent necrotic periocular tissue. " 03/01/2013 - "Necrotising fasciitis (NF) is a devastating disease with considerable mortality and morbidity, and early aggressive surgical debridement of devitalised necrotic tissues has traditionally been advocated. " 01/01/2013 - ""Emergency" definitive reconstruction of a necrotising fasciitis thigh debridement defect with a pedicled TRAM flap."
4.	Breast Implants (Breast Implant) 05/01/2001 - "Women with extracapsular silicone (silicone gel outside of the fibrous scar that forms around breast implants) were more likely to report having fibromyalgia (FM, p = 0.004) or other CTD, which included dermatomyositis, polymyositis, Hashimoto's thyroiditis, mixed CTD, pulmonary fibrosis, eosinophilic fasciitis, and polymyalgia (p = 0.008) than other women in the study. " 11/01/1992 - "The relationship between idiopathic forms of SSc and eosinophilic fasciitis/eosinophilia-myalgia syndrome caused by L-tryptophan ingestion and the scleroderma-like disease associated with silicone breast implants also is discussed."
5.	Hyperbaric Oxygenation 11/01/2015 - "In a single-centre, retrospective, case-controlled study of patients attending the Alfred Hospital in Prahran, Victoria, we assessed the effect of hyperbaric oxygen therapy (HBOT) in reducing mortality or morbidity in patients with necrotising fasciitis (NF) over a 13-year period from 2002 to 2014. " 10/01/2010 - "HOT (Hyperbaric Oxygen Therapy) is used in urological diseases: Scrotal/perineal fasciitis and Radiation-induced cystitis (and proctopathy); in urgency and frequency syndrome and with chronic pelvic pain the use of HOT is still experimental. "