Farnesol

A colorless liquid extracted from oils of plants such as citronella, neroli, cyclamen, and tuberose. It is an intermediate step in the biological synthesis of cholesterol from mevalonic acid in vertebrates. It has a delicate odor and is used in perfumery. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

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Networked: 87 relevant articles (7 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sultana, Sarwat: 5 articles (02/2012 - 01/2005)
2.	Nickerson, Kenneth W: 5 articles (10/2010 - 04/2007)
3.	Jetten, Anton M: 4 articles (10/2015 - 08/2007)
4.	Joo, Joung Hyuck: 4 articles (10/2015 - 08/2007)
5.	Mo, Huanbiao: 3 articles (05/2009 - 12/2003)
6.	Navarathna, Dhammika H M L P: 3 articles (02/2008 - 04/2007)
7.	Liao, Grace: 2 articles (10/2015 - 08/2007)
8.	Subramanian, Thangaiah: 2 articles (01/2014 - 09/2013)
9.	Spielmann, H Peter: 2 articles (01/2014 - 09/2013)
10.	Abe, Shigeru: 2 articles (11/2012 - 07/2008)

Related Diseases

1.	Body Weight (Weight, Body) 02/01/2012 - "To determine the protective effects of farnesol, it was administered orally at 2 doses (100 and 200 mg/kg body weight [b.w.]) once daily for 14 days. " 04/15/2005 - "No deaths occurred during the study, and farnesol had no significant effects on body weight, food consumption, clinical signs, or hematology/coagulation parameters. " 01/01/2015 - "The results showed that there were no significant differences in body weight, feed intake, and visceral organ weights between the farnesol supplementation and dietary control groups. " 04/01/1999 - "Unlike pharmacological Ca2+ channel blockers, farnesol blocked Ca2+ currents in the resting state: initial block was 63+/-8% in A7r5 cells and 50+/-9% in CHOC9 cells at a holding potential of -80 mV. We then gave 500 mg/kg body weight farnesol by gavage to Sabra hypertensive and normotensive rats and found that farnesol reduced blood pressure significantly in the hypertensive strain for at least 48 hours. " 07/15/2011 - "Farnesol was administered once daily for seven consecutive days at the doses of 50 and 100 mg/kg body weight in corn oil. "
2.	Neoplasms (Cancer) 07/01/2013 - "Remarkably, none of these genes conferred resistance to farnesol, indicating that this compound may be useful for the treatment of otherwise drug-resistant and refractory tumors expressing these mechanisms of resistance. " 07/01/2013 - "Farnesol exhibits cytotoxic activity against tumor cells in vitro and in vivo, implying that novel treatment strategies may be devised independent of Ras farnesylation. " 05/01/2014 - "Compared to the control group, tumor volume decreased significantly in the group administered 50 mg/kg farnesol. " 05/01/2014 - "The tumor growth inhibitory effect of farnesol was investigated in a mouse model. " 07/01/2013 - "Molecular determinants of cancer cell sensitivity and resistance towards the sesquiterpene farnesol."
3.	Wounds and Injuries (Trauma) 11/25/2008 - "Histopathological findings correlate with cellular and biochemical parameters of the lungs and potentiate the protective role of farnesol against CSE induced lung inflammation and injuries. " 11/25/2008 - "In this study we report the protective efficacy of farnesol against massive lung inflammation, oxidative stress and consequent injuries caused by cigarette smoke toxicants. " 02/01/2012 - "Benzo(a)pyrene-induced pulmonary inflammation, edema, surfactant dysfunction, and injuries in rats: alleviation by farnesol." 12/01/2009 - "Here, the model was exposed to the following biofilm effectors: xylitol, salicylic acid, farnesol, erythritol and two proprietary, semi-solid, wound-dressing formulations currently under development (Sanguitec gels). "
4.	Lung Injury 02/01/2012 - "Present study was designed to estimate chemopreventive effects of farnesol against B(a)P-induced pulmonary injuries. " 02/01/2012 - "However, pretreatment with farnesol at both the doses significantly reduced the lung injuries and inflammatory responses. " 11/25/2008 - "These results suggest a potent role of farnesol in protection of lung against cigarette smoke toxicants induced lung injuries." 11/25/2008 - "Farnesol ameliorates massive inflammation, oxidative stress and lung injury induced by intratracheal instillation of cigarette smoke extract in rats: an initial step in lung chemoprevention."
5.	Pneumonia (Pneumonitis) 02/01/2012 - "Present findings suggest a prominent role of farnesol against B(a)P-induced lung inflammation, edema, surfactant dysfunction, and epithelial damages in Wistar rats. " 11/25/2008 - "Histopathological findings correlate with cellular and biochemical parameters of the lungs and potentiate the protective role of farnesol against CSE induced lung inflammation and injuries. " 11/25/2008 - "In this study we report the protective efficacy of farnesol against massive lung inflammation, oxidative stress and consequent injuries caused by cigarette smoke toxicants. " 02/01/2012 - "Benzo(a)pyrene-induced pulmonary inflammation, edema, surfactant dysfunction, and injuries in rats: alleviation by farnesol."

Related Drugs and Biologics

1.	Lanosterol
2.	Smoke
3.	Iron
4.	Azoxymethane
5.	ferric nitrilotriacetate
6.	Squalene
7.	Hydroxymethylglutaryl CoA Reductases (HMG CoA Reductase)
8.	Systemic candidiasis
9.	geranylgeraniol
10.	geraniol (nerol)

Related Therapies and Procedures

1.	Chemoprevention
2.	Heterologous Transplantation (Xenotransplantation)
3.	Therapeutics
4.	Drug Therapy (Chemotherapy)
5.	Oral Administration