Flavin-Adenine Dinucleotide (FAD)

A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)

Also Known As:

Networked: 923 relevant articles (9 outcomes, 83 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ringman, John M: 13 articles (01/2014 - 07/2007)
2.	Sisodia, Sangram S: 10 articles (03/2014 - 01/2003)
3.	Lopera, Francisco: 8 articles (04/2014 - 05/2003)
4.	Robakis, Nikolaos K: 8 articles (08/2012 - 06/2002)
5.	Medina, Luis D: 7 articles (12/2013 - 01/2008)
6.	Cummings, Jeffrey L: 7 articles (12/2013 - 07/2007)
7.	Foskett, J Kevin: 6 articles (10/2015 - 06/2008)
8.	Rodriguez-Agudelo, Yaneth: 6 articles (12/2013 - 01/2008)
9.	Fasolato, Cristina: 6 articles (10/2012 - 03/2004)
10.	Pizzo, Paola: 6 articles (10/2012 - 03/2004)

Related Diseases

1.	Hypersensitivity (Allergy) 12/01/2015 - "European and US field studies have shown that fluralaner treatment alleviates the signs of flea allergy dermatitis (FAD) in client-owned dogs. " 01/01/2011 - "The study showed that the prevalence of ectoparasites on both dogs and cats was significantly higher on animals with flea allergy dermatitis (FAD) than those without FAD, and on animals with lesions on their skin compared with those without lesions." 06/01/2014 - "Canine flea-allergy dermatitis (FAD), a hypersensitivity response to antigenic material in the saliva of feeding fleas, occurs worldwide and remains a common presentation in companion animal veterinary practice despite widespread availability of effective systemic and topical flea-control products. " 01/01/2014 - "Improvements in veterinarian assessed flea allergy dermatitis (FAD) were observed in both groups. " 02/23/2010 - "Flea allergy dermatitis (FAD) is considered a harmful and persistent allergic disease in cats, dogs and humans. "
2.	Dermatitis 01/01/2013 - "In addition, some of the flea infested dogs (18.9%) were presenting signs of flea allergic dermatitis (FAD). " 12/01/2015 - "European and US field studies have shown that fluralaner treatment alleviates the signs of flea allergy dermatitis (FAD) in client-owned dogs. " 01/01/2011 - "The study showed that the prevalence of ectoparasites on both dogs and cats was significantly higher on animals with flea allergy dermatitis (FAD) than those without FAD, and on animals with lesions on their skin compared with those without lesions." 06/01/2014 - "Canine flea-allergy dermatitis (FAD), a hypersensitivity response to antigenic material in the saliva of feeding fleas, occurs worldwide and remains a common presentation in companion animal veterinary practice despite widespread availability of effective systemic and topical flea-control products. " 01/01/2014 - "Improvements in veterinarian assessed flea allergy dermatitis (FAD) were observed in both groups. "
3.	Atrophy 02/01/2013 - "These regions may be affected earliest during prodromal stages of FAD, while cortical atrophy may occur in later stages, when carriers show cognitive deficits. " 01/01/2011 - "FAD is associated with thinning of the posterior association and frontal cortices and hippocampal atrophy. " 05/01/2010 - "Fifteen of 28 asymptomatic at-risk persons were FAD mutation carriers and four of these were rated as having atrophy for a sensitivity of 27% and a specificity of 85%. " 11/01/2006 - "Presymptomatic FAD individuals show widespread MRglc reductions consistent with the typical AD PET pattern in the relative absence of structural brain atrophy. " 11/01/2006 - "After atrophy correction and adjusting for pons MRglc, PET MRglc reductions were found in all FAD subjects compared with controls in the WB (13%), bilaterally in the IPL (17%) and in the STG (12%), and in the left EC (21%), PCC (20%), and Hip (12%) (P values < 0.05). "
4.	Flea Infestations 02/23/2010 - "In this report, we clinically tested this protocol to treat established FAD in cats following flea infestations. " 08/01/1978 - "Diagnosis of FAD was based on history of flea infestation and on type and location of lesions. " 08/23/2000 - "Results of these studies indicated that selamectin was highly effective in the control of flea infestations in dogs and cats without the need for simultaneous treatment of the environment or of in-contact animals and also was beneficial in alleviating signs associated with FAD. " 01/01/2000 - "This study demonstrates that a single treatment with imidacloprid is able to effectively control flea infestations in dogs and cats for at least 28 days and significantly contributes to the improvement or disappearance of clinical signs of FAD." 06/01/2014 - "Topical indoxacarb treatment applied every 4 weeks for 12 weeks, without concomitant antipruritic or ectoparasiticide therapy, completely alleviated flea infestations in all dogs and associated clinical signs of FAD in a high proportion of this population of dogs in a challenging flea-infestation environment."
5.	Breast Neoplasms (Breast Cancer) 12/01/2012 - "We inserted the CvFad3 gene into the plasmid pEGFP-C3 to construct the eukaryotic expression vector pEGFP-C3-n-3 and to express the n-3 Fad gene in human breast cancer cells (MCF-7 cells). " 10/01/2000 - "Together, these data suggest that TNF-regulated MMP-9 may play a role in the controlled invasion of the fad pad that occurs during normal mammary gland development and that misregulation of MMP-9 may contribute to the invasiveness of breast cancer." 12/03/1997 - "Pesticides and breast cancer: fact or fad?" 01/01/1976 - "Patients "cured" of FCD or FAD represented a pool of potential plasma donors for immunotherapy of recurrent breast cancer." 01/01/1976 - "Sera from 4 individuals clinically free of FCD or breast fibroadenoma (FAD) neutralized the blocking activity in the sera of patients with metastatic breast cancer. "

Related Drugs and Biologics

1.	Adrenocorticotropic Hormone (ACTH)
2.	selamectin
3.	spinosad
4.	Serine (L-Serine)
5.	D-Amino-Acid Oxidase (D-Amino Acid Dehydrogenase)
6.	Antipsychotic Agents (Antipsychotics)
7.	serine racemase
8.	Amyloid (Amyloid Fibrils)
9.	NAD (NADH)
10.	Presenilin-1

Related Therapies and Procedures

1.	Oral Administration
2.	Immunotherapy
3.	Contraception (Birth Control)
4.	Carbohydrate-Restricted Diet (Low Carbohydrate Diet)
5.	Fat-Restricted Diet (Diet, Fat Restricted)