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Factor XIII (Coagulation Factor XIII)

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A fibrin-stabilizing plasma enzyme (TRANSGLUTAMINASES) that is activated by THROMBIN and CALCIUM to form FACTOR XIIIA. It is important for stabilizing the formation of the fibrin polymer (clot) which culminates the coagulation cascade.

Also Known As:

Coagulation Factor XIII; Blood Coagulation Factor XIII; Factor XIII A-Chain; Laki Lorand Factor; Factor XIII A Chain; Factor XIII, Coagulation; Stabilizing Factor, Fibrin; Transamidase, Factor XIII; XIII, Coagulation Factor; Factor XIII Transamidase; Fibrin Stabilizing Factor; Fibrinase; Laki-Lorand Factor; Blood-coagulation factor XIII

Networked: 709 relevant articles (25 outcomes, 57 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Muszbek, László: 12 articles (01/2015 - 09/2003)
2.	Bereczky, Zsuzsanna: 10 articles (01/2015 - 09/2003)
3.	Katona, Eva: 9 articles (01/2009 - 09/2003)
4.	Gemmati, Donato: 8 articles (07/2015 - 12/2002)
5.	Ichinose, Akitada: 8 articles (06/2015 - 12/2003)
6.	Rosendaal, Frits R: 8 articles (05/2011 - 02/2002)
7.	Kohler, H P: 7 articles (07/2014 - 08/2000)
8.	Souri, Masayoshi: 6 articles (06/2015 - 12/2010)
9.	Dickneite, Gerhard: 6 articles (05/2013 - 12/2002)
10.	Marín, Francisco: 6 articles (09/2010 - 08/2002)

Related Diseases

1.	Hemorrhage 03/01/1988 - "Massive infusion of plasma and factor XIII concentrate was effective for controlling the bleeding temporarily. " 03/01/2006 - "Patients reporting a current systemic bleeding tendency at study entry had significantly reduced factor XIII. In a 6-year follow-up, patients with factor XIII<50% had a significantly increased risk of severe upper gastrointestinal bleed, and reduced factor XIII (<50%, 50-75% vs. normal) was associated with increased mortality. " 07/01/2015 - "We report here two cases of congenital deficiency of factor XIII, revealed by spontaneous intra-axial hemorrhage, one of them manifested with an intramedullary hemorrhage never described in the literature before. " 03/01/2015 - "Factor XIII (FXIII) deficiency is an extremely rare bleeding disorder, which has the highest incidence in Sistan and Baluchistan Province in Iran, compared to its overall incidence around the world. " 02/26/2015 - "Factor XIII-A deficiency causes a severe bleeding phenotype and impaired wound healing, but the cellular origin of Factor XIII-A is unknown. "
2.	Myocardial Infarction 04/01/2003 - "Only for factor XIII 34Leu a protective effect on the development of myocardial infarction has been demonstrated in several studies. " 07/01/2015 - "Factor XIII-A dynamics in acute myocardial infarction: a novel prognostic biomarker?" 11/01/2014 - "The association between factor XIII-A (FXIII-A) Val34Leu polymorphism and myocardial infarction (MI) risk remained controversial. " 11/01/2014 - "Effect of factor XIII-A Val34Leu polymorphism on myocardial infarction risk: a meta-analysis." 01/01/2014 - "Factor XIII-A Val34Leu polymorphism might beassociated with myocardial infarction risk: an updated meta-analysis."
3.	Venous Thrombosis (Deep-Vein Thrombosis) 02/01/1999 - "It is concluded that possession of the Leu allele at factor XIII Val34Leu is protective against deep venous thrombosis." 02/01/2007 - "While there was a slightly greater prevalence of Factor XIII mutation carriership in CD, we did not find that gene mutations for these four common factors could explain the greater risk of venous thrombosis in CD and UC." 11/01/2005 - "A novel polymorphism in the factor XIII B-subunit (His95Arg): relationship to subunit dissociation and venous thrombosis." 07/01/2001 - "The role of a common polymorphism in the factor XIII A-subunit gene (FXIII Val34Leu) has been recently investigated as a protective genetic factor against arterial and venous thrombosis. " 12/01/2000 - "Factor XIII Val34Leu polymorphism and risk of deep vein thrombosis."
4.	Venous Thromboembolism 10/01/2006 - "The factor XIII Val34Leu polymorphism: is it protective against idiopathic venous thromboembolism?" 07/15/2006 - "Factor XIII Val34Leu variant is protective against venous thromboembolism: a HuGE review and meta-analysis." 01/01/2015 - "[Factor XIII-A subunit Val34Leu polymorphism and risk of venous thromboembolism in young adults]." 04/01/2011 - "Factor XIII and venous thromboembolism." 09/01/2003 - "The role of coagulation factor XIII (FXIII) levels in acute venous thromboembolism is not known. "
5.	Factor XIII Deficiency 05/31/2012 - "Recombinant factor XIII: a safe and novel treatment for congenital factor XIII deficiency." 05/01/2000 - "We analysed the early implantation tissues of normal women and of a patient with congenital factor XIII deficiency in order to study the role of maternal subunit A of factor XIII (XIIIA) in the development of extravillous cytotrophoblast. " 01/01/1996 - "Acquired factor XIII deficiency, however, is much more common, and preliminary studies suggest a lack of factor XIII to be an important feature of various diseases. " 12/10/1982 - "A randomized and controlled study was undertaken to test whether substitution with factor XIII concentrates influences the clinical course in patients with acute leukaemia and acquired factor XIII deficiency (less than or equal to 60%). " 01/01/2015 - "Pharmacokinetics and safety of plasma-derived factor XIII concentrate (human) in patients with congenital factor XIII deficiency."

Related Drugs and Biologics

1.	Factor XIII (Coagulation Factor XIII)
2.	Fibrinogen (Factor I)
3.	Thrombin
4.	Methylene Blue (Methylthioninium Chloride)
5.	Antibodies
6.	Fibrin Tissue Adhesive (Fibrin Sealant)
7.	recombinant FVIIa (rFVIIa)
8.	Platelet Factor 4
9.	Gelatin
10.	Familial duodenal atresia

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Craniotomy
3.	Sclerotherapy
4.	Sutures (Suture)
5.	Lasers (Laser)