Factor XII (Hageman Factor)

Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased incidence of thromboembolic disease. Mutations in the gene for factor XII that appear to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA TYPE III.

Also Known As:

Networked: 458 relevant articles (8 outcomes, 38 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Renné, Thomas: 24 articles (09/2015 - 07/2005)
2.	Gailani, David: 12 articles (03/2014 - 07/2005)
3.	Kleinschnitz, Christoph: 9 articles (01/2014 - 03/2006)
4.	Nieswandt, Bernhard: 9 articles (02/2012 - 07/2005)
5.	Bork, Konrad: 7 articles (01/2015 - 05/2006)
6.	Stoll, Guido: 7 articles (02/2012 - 03/2006)
7.	Björkqvist, Jenny: 5 articles (08/2015 - 02/2011)
8.	Maas, Coen: 5 articles (08/2015 - 09/2008)
9.	Tucker, Erik I: 5 articles (03/2014 - 01/2009)
10.	McCarty, Owen J T: 5 articles (03/2014 - 01/2009)

Related Diseases

1.	Hemorrhage 12/01/2015 - "Factor XII full and partial null in rat confers robust antithrombotic efficacy with no bleeding." 01/01/2014 - "we here report a case of ET accompanied with coagulation factor XII deficiency, which had clinically significant bleeding tendency. " 05/01/2012 - "In our case, a deficiency of factor XII was found, which is not associated with an increased bleeding risk. " 05/01/2012 - "Ten patients had decreased factor XII. Five patients had a suspected bleeding disorder which was confirmed in two of them. " 04/01/2011 - "Targeting polyphosphate-mediated factor XII activation offers the exciting possibility for a safe anticoagulation with minimal therapy-associated bleeding."
2.	Thrombosis (Thrombus) 04/06/2010 - "Recent studies with factor XII-deficient mice revealed that the factor XII-induced intrinsic coagulation pathway is essential for pathological thrombus formation but dispensable for hemostasis. " 01/01/2015 - "Coagulation factor XII (fXII) is important for arterial thrombosis, but its physiological activation mechanisms are unclear. " 12/01/2014 - "Generation of active Factor XII (FXIIa) triggers blood clotting on artificial surfaces and may also enhance intravascular thrombosis. " 09/01/2014 - "Factor XII is also a key component in the fibrinolytic system and its deficiency is associated with increased thrombosis. " 08/01/2014 - "Factor XII regulates the pathological process of thrombus formation on ruptured plaques."
3.	Stroke (Strokes) 09/01/2012 - "Contact factor XII (FXII), an upstream activator of FXI, also contributes to experimental stroke, but is not required for hemostasis. " 02/01/2012 - "Blood coagulation factor XII--a neglected player in stroke pathophysiology." 09/01/2011 - "Further experimental work indicates that these pathways in conjunction with coagulation factor XII (FXII)-driven processes orchestrate a 'thrombo-inflammatory' cascade in acute stroke that results in infarct growth. " 02/15/2010 - "Intrinsic coagulation factor XII deficient (FXII(-/-)) mice are protected from ischemic stroke. " 02/15/2010 - "Enhanced cortical reperfusion protects coagulation factor XII-deficient mice from ischemic stroke as revealed by high-field MRI."
4.	Inflammation 09/01/2008 - "Patient studies, genetically altered mouse models, and plasma assays analyzed functions of the factor XII-driven contact activation system for coagulation and inflammation. " 01/01/1993 - "Factor XII activation and inhibition in inflammation." 07/01/1978 - "A review of current knowledge of the biochemical mechanisms involved in the Hageman factor system is presented because of the potential role of these components in the development of inflammation." 04/01/2004 - "Thrombolytic therapy activates the contact system, and factor XII activation may activate the coagulation cascade and inflammation. " 09/01/2014 - "Factor XII: a drug target for safe interference with thrombosis and inflammation."
5.	Habitual Abortion (Recurrent Miscarriage) 01/01/2000 - "The aim of this study was to assess the prevalence of factor XII (FXII) deficiency in women with a history of recurrent miscarriage. " 01/01/2014 - "Role of coagulation factor XII in unexplained recurrent abortions in the Greek population." 04/01/2008 - "A decrease in factor XII (FXII) activity has been observed in women with unexplained recurrent miscarriages. " 10/01/2005 - "The C46T polymorphism of the coagulation factor XII gene and idiopathic recurrent miscarriage." 09/01/2003 - "Ten of 67 women with primary recurrent abortion (14.9%) and 4 of 33 women (12.1%) with secondary recurrent abortion had reduced factor XII activity (<60%). "

Related Drugs and Biologics

1.	Factor XI (Plasma Thromboplastin Antecedent)
2.	Proteins (Proteins, Gene)
3.	High-Molecular-Weight Kininogen (Kininogen, High Molecular Weight)
4.	Plasma Kallikrein
5.	Aspirin (Acetylsalicylic Acid)
6.	Complement C1s (C1 Esterase)
7.	bismuth subgallate
8.	Prekallikrein
9.	Thrombin
10.	Antithrombin III

Related Therapies and Procedures

1.	Thrombolytic Therapy
2.	Intravenous Injections
3.	Transplants (Transplant)
4.	Renal Dialysis (Hemodialysis)
5.	Aftercare (After-Treatment)