Factor V (Coagulation Factor V)

Heat- and storage-labile plasma glycoprotein which accelerates the conversion of prothrombin to thrombin in blood coagulation. Factor V accomplishes this by forming a complex with factor Xa, phospholipid, and calcium (prothrombinase complex). Deficiency of factor V leads to Owren's disease.

Also Known As:

Networked: 1327 relevant articles (21 outcomes, 104 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Castoldi, E: 10 articles (03/2015 - 03/2000)
2.	Castoldi, Elisabetta: 10 articles (08/2014 - 09/2002)
3.	Dahlbäck, Björn: 10 articles (09/2013 - 10/2002)
4.	Akar, N: 10 articles (01/2008 - 02/2000)
5.	Bernardi, F: 9 articles (12/2005 - 03/2000)
6.	Simioni, P: 8 articles (03/2015 - 08/2000)
7.	Rosing, Jan: 8 articles (08/2014 - 09/2002)
8.	Asselta, Rosanna: 8 articles (08/2011 - 01/2003)
9.	Peyvandi, Flora: 8 articles (07/2011 - 10/2002)
10.	Lunghi, B: 8 articles (12/2005 - 03/2000)

Related Diseases

1.	Activated Protein C Resistance (APC Resistance) 11/01/1997 - "Coatest APC Resistance V and Accélérimat were proven to be the methods most able to discriminate for factor V:Q506, while normalization was not shown to improve the screening performance. " 05/01/1998 - "Predilution of patient plasma with factor V-deficient plasma results in improved sensitivity and specificity of the COATEST APC Resistance Kit, thus offering a simple modification to enhance APC resistance determination in the routine clinical laboratory setting." 11/01/1996 - "Improved characteristics of aPC-resistance assay: Coatest aPC resistance by predilution of samples with factor V deficient plasma." 08/15/1997 - "Moreover, the study of 10 patients with APC resistance in the absence of the factor V R506Q mutation showed a 50-fold higher frequency of HR2 homozygotes. " 09/01/1996 - "Subsequent studies identified a point mutation in the gene for factor V as the underlying cause of APC-Resistance. "
2.	Hemorrhage 02/01/1993 - "Bleeding was unrelated to absolute fall in factor V level, but cessation of hemorrhage appeared to correlate with improvement in factor V level. " 03/12/2015 - "A novel mutation in the F5 gene (factor V Amsterdam) associated with bleeding independent of factor V procoagulant function." 03/01/2015 - "Coagulation factor V (FV) deficiency is a rare autosomal recessive bleeding disorder. " 01/01/2015 - "The management of patients with acquired factor V inhibitors is challenging, because their bleeding risk is highly variable and only poorly correlated with routine coagulation tests. " 01/01/2015 - "Factor V (FV) deficiency is a rare autosomal recessive bleeding disorder caused by mutations in the F5 gene. "
3.	Thrombosis (Thrombus) 02/01/2009 - "At multivariate study, RP percentage, factor V levels, and aAPCR were independently associated with an increased risk of thrombosis. " 01/01/2003 - "The dual role of factor V as a coagulatory and anticoagulatory cofactor permits the assumption that further mutations in the factor V gene are of importance in the study of the risk of thrombosis. " 09/01/1997 - "Due to the high prevalence of C677T MTHFR, it is likely that previous studies, which did not look for this mutation, overestimated the relative risk of thrombosis associated with factor V:Q506 alone." 05/01/1995 - "This study compared a rapid method to detect the nucleotide mutation 1691 G-->A, responsible for the factor V Arg506-->Gln substitution, with a previously established denaturing gradient gel electrophoresis (DGGE) technique in 136 patients with unexplained thrombosis. " 04/01/1995 - "In this study, patients with FV Q506 were of a younger age and had a higher incidence of extensive thrombosis or recurrence as compared to those with the normal factor V gene. "
4.	Venous Thromboembolism 02/01/2004 - "Factor V HR2 is associated with a mild increase in the risk of venous thromboembolism although not all studies concur on this point. " 04/15/2002 - "The aim of this study was to examine the occurrence of venous thromboembolism (VTE) in relation to factor V-related risk factors. " 01/01/2015 - "FVL is caused by a single point mutation in the gene coding for coagulation factor V (FV) causing a lifelong procoagulatory state with an increased risk of venous thromboembolism (VTE) which might be fatal. " 03/01/2007 - "To identify the relationship between coagulation factor V (FV) gene single nucleotide polymorphisms (SNPs) and venous thromboembolism (VTE). " 03/01/2007 - "[The related analysis of venous thromboembolism and cSNPs of coagulation factor V gene]."
5.	Factor V Deficiency 12/20/1993 - "Factor V deficiency and specific inhibitors of factor V yielded, in some instances, false positive results." 10/01/2008 - "In the present study, we investigated the molecular basis of factor V deficiency in three patients, and performed a comprehensive analysis of the factor V gene (F5) splicing pattern. " 01/01/1996 - "These studies provide the first evidence of a genetic component in determining factor V levels in plasma and of a genetic linkage between the factor V gene and factor V deficiency. " 07/01/1955 - "Hereditary deficiency of proaccelerin (parahemophilia): a family study." 04/01/2014 - "Recently, we detected two genetic variations in factor V of a Chinese patient with hereditary factor V deficiency. "

Related Drugs and Biologics

1.	Prothrombin (Factor II)
2.	factor V Leiden
3.	Fibrinogen (Factor I)
4.	Factor V (Coagulation Factor V)
5.	Antibodies
6.	Proteins (Proteins, Gene)
7.	Plasminogen Activators (Plasminogen Activator)
8.	A-factor (Streptomyces)
9.	Factor VIII (Coagulation Factor VIII)
10.	Protein C

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Estrogen Replacement Therapy
3.	Catheters
4.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
5.	Debridement