Exodeoxyribonucleases

A family of enzymes that catalyze the exonucleolytic cleavage of DNA. It includes members of the class EC 3.1.11 that produce 5'-phosphomonoesters as cleavage products.

Also Known As:

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cox, Lynne S: 1 article (12/2012)
2.	Mason, Penelope A: 1 article (12/2012)

Related Diseases

1.	Genomic Instability 12/01/2012 - "The role of DNA exonucleases in protecting genome stability and their impact on ageing."
2.	Lyme Disease (Disease, Lyme) 12/15/1997 - "Results indicate that it is also present in the RNase T family; Borrelia burgdorferi P93 protein, an immunodominant antigen in Lyme disease; bacteriophage T4 dexA and Escherichia coli exonuclease I, processive 3'-->5' exodeoxyribonucleases that degrade single-stranded DNA; Bacillus subtilis dinG, a probable helicase involved in DNA repair and possibly replication, and peptide synthase 1; Saccharomyces cerevisiae Pab1p-dependent poly(A) nuclease PAN2 subunit, required for shortening mRNA poly(A) tails; Caenorhabditis elegans and Mus musculus CAF1, transcription factor CCR4-associated factor 1; Xenopus laevis XPMC2, prevention of mitotic catastrophe in fission yeast; Drosophila melanogaster egalitarian, oocyte specification and axis determination, and exuperantia, establishment of oocyte polarity; H.sapiens HEM45, expressed in tumour cell lines and uterus and regulated by oestrogen; and 31 open reading frames including one in Methanococcus jannaschii . "

Related Drugs and Biologics

1.	Transcription Factors (Transcription Factor)
2.	Messenger RNA (mRNA)
3.	Proteins (Proteins, Gene)
4.	Poly A
5.	Peptides (Polypeptides)
6.	Single-Stranded DNA (DNA, Single Stranded)
7.	Antigens
8.	poly(A)-specific ribonuclease
9.	exoribonuclease T
10.	exodeoxyribonuclease I