Glucan 1,4-alpha-Glucosidase

An enzyme that catalyzes the hydrolysis of terminal 1,4-linked alpha-D-glucose residues successively from non-reducing ends of polysaccharide chains with the release of beta-glucose. It is also able to hydrolyze 1,6-alpha-glucosidic bonds when the next bond in sequence is 1,4.

Also Known As:

Glucoamylase G1; Glucoamylase G2; 1,4-alpha-Glucosidase, Glucan; Exo 1,4 alpha Glucosidase; Glucan 1,4 alpha Glucosidase; gamma Amylase; 1,4-alpha-Glucosidase, Exo; Amyloglucosidase; Exo-1,4-alpha-Glucosidase; Glucoamylase; gamma-Amylase; 1,4-alpha-D-Glucan glucohydrolase

Networked: 51 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Glycoside Hydrolases: 871
      - Glucosidases: 1733
        Glucan 1,4-alpha-Glucosidase: 51
        Amorphotheca resinae GamP protein
        S cerevisiae SGA1 protein

Experts

1.	Kondo, Akihiko: 2 articles (02/2013 - 02/2010)
2.	Ogino, Chiaki: 2 articles (02/2013 - 02/2010)
3.	Yamada, Ryosuke: 2 articles (02/2013 - 02/2010)
4.	Bai, Suk: 2 articles (08/2011 - 08/2007)
5.	Ko, Hyun-Mi: 2 articles (08/2011 - 08/2007)
6.	Lee, Hwanghee Blaise: 2 articles (08/2011 - 08/2007)
7.	Chowdhury, Madhumita R: 1 article (01/2020)
8.	Gupta, Neerja: 1 article (01/2020)
9.	Kabra, Madhulika: 1 article (01/2020)
10.	Kaur, Punit: 1 article (01/2020)

Related Diseases

1.	Diarrhea 10/01/2002 - "Glucoamylase deficiency is reported to cause chronic diarrhea in infants, but its role in dyspeptic children is unknown. " 04/01/1994 - "We conclude that intestinal glucoamylase deficiency is present in some patients with chronic diarrhea." 07/01/2023 - "This suggests that inclusions of supplemental protease (12,000 U/kg), glucoamylase (60,000 U/kg), or Pediococcus acidilactici BCC-1 (109 cfu/kg) individually or in combination with xylanase (4,800 U/kg) in the newly harvested corn diets can alleviate diarrhea in broilers, and be beneficial for the gut health." 04/01/1994 - "To determine the prevalence of short polymers of glucose and starch malabsorption caused by small intestinal glucoamylase deficiency in children with chronic diarrhea, we studied small bowel biopsy specimens from 511 children (aged 1 month to 9 years) with chronic diarrhea evaluated at 54 medical centers. " 01/01/1994 - "The involvement of osmotic component was suggested in view of incomplete hydrolysis of carbohydrates by small intestinal glucoamylase under mono- and bisubstrate digestion, whereas diarrhea secretory component develops in participation of cyclic nucleotides. "
2.	Cysts 03/01/1992 - "Periodic acid-Schiff staining and gas chromatography/mass spectrometry (GC/MS) of intact and treated cyst hydrolysates showed a significant reduction in the amount of glucose associated with the cyst (72 nmoles/10(6) intact cysts vs 1.9 nmoles/10(6) ACW) as a result of amyloglucosidase treatment, indicating that glucose is stored within Giardia as an SDS-insoluble polymer. " 03/01/1992 - "The SDS-insoluble, amyloglucosidase-fast cyst walls (ACW) were further incubated with chymotrypsin, trypsin, papain, or pronase. " 03/01/1992 - "Intact Giardia muris cysts were subjected to consecutive chloroform/methanol and 2% sodium dodecyl sulfate (SDS) extractions, and to amyloglucosidase treatment. " 08/01/2009 - "Cyst walls were prepared by removing intracellular material from cysts by pre-treating them with sodium dodecyl sulphate (SDS) containing dithiothreitol, and then subjecting these to a series of sequential enzymatic digestions using amyloglucosidase, papain, DNase, RNase and proteinase K. "
3.	Aphthous Stomatitis (Aphthous Ulcer) 01/01/1993 - "The aim of this study was to assess whether a toothpaste containing amyloglucosidase and glucose oxidase (Z) provoked any effect on minor recurrent aphthous ulcers, (RAU) as compared with a placebo toothpaste (P). " 01/01/1999 - "Effect of a mouth rinse containing amyloglucosidase and glucose oxidase on recurrent aphthous ulcers in children and adolescents." 01/01/1993 - "Effect of a toothpaste containing amyloglucosidase and glucose oxidase on recurrent aphthous ulcers."
4.	Atypical Squamous Cells of the Cervix 12/01/1988 - "[Studies on formation of glucoamylase in Mon ascus as 3.3491]."
5.	Dehydration (Water Stress) 01/01/2023 - "In this study, we investigated the effects of gum arabic (AG), sodium alginate (SA), locust bean gum (LG), and guar gum (GG) on kudzu starch from the perspective of its particle size, pasting, texture, rheology, dehydration rate, thermal properties, microstructure, and sensitivity to amyloglucosidase. "

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Polymers
3.	Periodic Acid
4.	Peptide Hydrolases (Proteases)
5.	Toothpastes
6.	Glucose Oxidase
7.	Starch (Cornstarch)
8.	Gum Arabic (Acacia, Gum)
9.	Alginates
10.	locust bean gum (carob)

Related Therapies and Procedures

1.	Toothbrushing