Excipients (Suspending Agents)

Usually inert substances added to a prescription in order to provide suitable consistency to the dosage form. These include binders, matrix, base or diluent in pills, tablets, creams, salves, etc.

Also Known As:

Networked: 274 relevant articles (21 outcomes, 27 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Miller, John H: 5 articles (06/2015 - 03/2007)
2.	Northcote, Peter T: 5 articles (06/2015 - 03/2007)
3.	Orlowski, Katrin: 3 articles (04/2015 - 09/2011)
4.	Pruschy, Martin: 3 articles (04/2015 - 09/2011)
5.	Ballatore, Carlo: 3 articles (09/2014 - 08/2012)
6.	Brunden, Kurt R: 3 articles (09/2014 - 08/2012)
7.	Trojanowski, John Q: 3 articles (09/2014 - 08/2012)
8.	Lee, Virginia M-Y: 3 articles (09/2014 - 08/2012)
9.	Smith, Amos B: 3 articles (09/2014 - 08/2012)
10.	Barbaud, A: 3 articles (05/2012 - 12/2005)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2015 - "This inhibition of endothelial cell function occurred at relatively non-cytotoxic concentrations over the 16-18 h incubations for both stabilizing agents, suggesting that anti-angiogenic effects are likely to occur before therapeutically relevant doses begin to inhibit tumor growth or adverse side effects develop." 04/01/2015 - "Resistance to microtubule-stabilizing agents is a major hurdle for successful cancer therapy. " 09/15/2014 - "Accordingly, a possible therapeutic strategy for such neurodegenerative conditions is to treat with MT-stabilizing agents, such as those that have been used in the treatment of cancer. " 01/01/2014 - "Our work provides a link between targeting the ubiquitously occurring actin CSK and selective inhibition of pro-tumorigenic PKCɛ, thus setting the stage for actin-stabilizing agents as innovative cancer drugs. " 01/01/2014 - "Proteomics of cancer cell lines resistant to microtubule-stabilizing agents."
2.	Bipolar Disorder (Mania) 08/01/2004 - "Further studies are needed on gestational timing and exposure to mood-stabilizing agents, especially newer agents recently approved or currently being considered for the treatment of bipolar disorder." 09/01/2001 - "Use of antipsychotic medication intermittently or over the long term may be necessary in treating patients with bipolar disorder whose symptoms have responded suboptimally to standard mood-stabilizing agents. " 03/01/2001 - "Since the first episode of mania typically occurs before the age of 30, many women in their prime childbearing years may be exposed to potentially teratogenic mood-stabilizing agents. " 08/01/1998 - "Greater attention to suicidal risk in patients with bipolar depression and assessment of all proposed mood-stabilizing agents for antisuicidal effects are strongly encouraged." 12/01/1992 - "The treatment of bipolar disorders with mood stabilizing agents is complicated by breakthrough episodes of depression. "
3.	Acne Vulgaris 10/01/2013 - "The occluded patch test seemed to indicate that the formulation excipients were safe and thus AzA-loaded nanoparticles appear to be an efficient and safe treatment for acne." 05/01/2009 - "The current 12-week study aimed to compare the efficacy of a clindamycin 1%-BPO 5% topical gel with the hydrating excipients dimethicone and glycerin (C/BPO HE) and a clindamycin 1%-BPO 5% topical gel that does not contain hydrating excipients (C/BPO) applied once daily for the treatment of 20 participants with facial acne vulgaris and to determine if there were differences in product preference and participant acceptability between the treatments. " 10/01/2009 - "This study investigated the efficacy, tolerability, and safety of 2 fixed-dose combination gels for the treatment of facial acne: clindamycin 1%-benzoyl peroxide 5% gel with hydrating excipients (C/BPO HE) and adapalene 0.1%-benzoyl peroxide 25% gel (A/BPO). "
4.	Infection 05/01/2012 - "Lipid based excipients have been developed in "depot" formulations to extend the period of effective prevention of parasite re-infection. " 05/01/2006 - "The very low excipients content (about 5% m/m) of these formulations offers the benefit of delivering particularly huge concentrations of antibiotic directly to the site of infection, while minimizing systemic exposure, and may provide a valuable alternative treatment of cystic fibrosis." 02/01/2009 - "On the other hand, carbon nanotubes can be readily functionalized and several studies on the use of carbon nanotubes as versatile excipients for drug delivery and imaging of disease processes have been reported, suggesting that carbon nanotubes may have a place in the armamentarium for treatment and monitoring of cancer, infection, and other disease conditions. " 03/01/1998 - "Treatment of asexual Plasmodium falciparum infections with the microtubule stabilizing agents Taxol or epothilone A prevents the depolymerization of nuclear microtubules. " 02/01/1978 - "Thenium closylate-piperazine phosphate combination tablets, tablets containing either thenium or piperazine, and control tablets (excipients only) were administered in 2 doses 5 to 7.5 hours apart to weaned pups and young dogs, in critical controlled trials to test efficacy against naturally acquired infections of Toxocara canis. "
5.	Hypersensitivity (Allergy) 08/01/2014 - "Hypersensitivity reactions to excipients contained in drugs are rare but can be severe or confusing. " 04/01/2011 - "Mast cell stabilizing agents and AMG-modulated systems seem to interact through yet undefined mechanisms in the different phases of ocular hypersensitivity reactions." 09/01/2008 - "Patients with allergies or intolerances and those requiring special diets are among the groups that require formulations with special excipients. " 01/01/2008 - "Whereas allergy to vehicle ingredients (ie, excipients and preservatives) in topical steroid vehicles is well recognized, there are no data regarding which vehicle ingredients are in common use or on which vehicles and active molecules are associated with which ingredients. " 07/01/2005 - "By interrelating tables listing active ingredients, excipients, chemical structures/functional groups, and "group allergies" prescriptions may be interactively checked, and useful information is provided to the prescribing practitioner--as well as the whole multidisciplinary team--to help him make his/her decisions."

Related Drugs and Biologics

1.	Tablets
2.	Epothilones (Epothilone)
3.	Paclitaxel (Taxol)
4.	Polymers
5.	Glycerol (Glycerine)
6.	Clindamycin (Cleocin)
7.	Valproic Acid (Valproate, Semisodium)
8.	Antidepressive Agents (Antidepressants)
9.	Calcium
10.	Carbamazepine (Tegretol)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Chronotherapy
3.	Intramuscular Injections
4.	Bandages (Bandage)
5.	Therapeutics