Exanthema Subitum (Roseola Infantum)

An acute, short-lived, viral disease of infants and young children characterized by a high fever at onset that drops to normal after 3-4 days and the concomitant appearance of a macular or maculopapular rash that appears first on the trunk and then spreads to other areas. It is the sixth of the classical exanthematous diseases and is caused by HHV-6; (HERPESVIRUS 6, HUMAN). (From Dorland, 27th ed)

Also Known As:

Networked: 26 relevant articles (0 outcomes, 4 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Exanthema Subitum (Roseola Infantum)
2.	Exanthema (Rash)
3.	Encephalitis (Encephalitis, Rasmussen)
4.	Febrile Seizures (Febrile Seizure)
5.	Infections

Experts

1.	Ihira, Masaru: 2 articles (03/2021 - 06/2006)
2.	Yoshikawa, Tetsushi: 2 articles (03/2021 - 06/2006)
3.	Mamishi, Setareh: 2 articles (09/2014 - 04/2014)
4.	Yavarian, Jila: 2 articles (09/2014 - 04/2014)
5.	Pedrazini, Maria Cristina: 1 article (11/2021)
6.	da Silva, Mariliza Henrique: 1 article (11/2021)
7.	Hattori, Fumihiko: 1 article (03/2021)
8.	Kawamura, Yoshiki: 1 article (03/2021)
9.	Kozawa, Kei: 1 article (03/2021)
10.	Kurahashi, Hiroki: 1 article (03/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Exanthema Subitum:

1.	AntibodiesIBA 01/01/1996 - "Our study also confirmed that antibodies are acquired very early in life in the same age group as exanthema subitum does." 03/26/2021 - "They did not have past histories of exanthema subitum but had antibodies against HHV-6A and HHV-6B. " 05/23/1992 - "33 of them already had HHV-6 antibodies in their first blood sample although their history was negative concerning exanthema subitum. " 01/01/1992 - "Twenty-five patients with clinical exanthema subitum (roseola infantum) were enrolled into a study, where acute-phase and convalescent sera were examined for antibodies to human herpesvirus 6 (HHV-6), several other viruses, and other microbes. " 06/01/1991 - "[Seroprevalence of antibodies to human herpesvirus 6 (exanthema subitum; critical 3-day fever-exanthema in young children) in the population of Northern Germany]."
2.	DNA (Deoxyribonucleic Acid)IBA 10/01/1996 - "The degree of DNA homology between variants ranges from 97% in the most conserved region to 75% in the immediate early region 1. HHV-6B is the etiologic agent of exanthema subitum but HHV-6A has not yet been clearly associated with any human pathology. " 09/01/2014 - "The aim of this study was detection of human herpesvirus-6 (HHV-6) DNA in cerebrospinal fluid (CSF) of patients with symptoms of possible acute encephalitis and without typical signs or symptoms of roseola infantum, using real-time polymerase chain reaction (PCR). " 04/01/2014 - "The objective of this study was to determine the prevalence of HHV-6 by detecting DNA in cerebrospinal fluid (CSF) of children with febrile convulsion and without any rash of roseola infantum. " 01/01/2019 - "Human herpesvirus-6 (HHV-6) is a ubiquitous double-stranded DNA virus that can cause roseola infantum, encephalitis, and seizure disorders. "
3.	Interleukin-6 (Interleukin 6)IBA 01/01/2003 - "Frequent seizures with elevated interleukin-6 at the eruptive stage of exanthema subitum." 01/01/2002 - "Frequent seizures with elevated interleukin-6 at the eruptive stage of exanthema subitum."
4.	Peptides (Polypeptides)IBA 03/01/1990 - "Seroreactivity to HHV-6 polypeptides in infants with exanthema subitum and their mothers." 11/01/1989 - "Immune response of patients with exanthema subitum to human herpesvirus type 6 (HHV-6) polypeptides."
5.	Immunoglobulin M (IgM)IBA 12/01/1990 - "The data suggest that there are clinical syndromes in addition to roseola infantum associated with the presence of IgM anti-HHV6, in which serological screening for evidence of acute HHV6 infection may be useful." 09/01/1991 - "Exanthema subitum was described in 1910 by John Zahorsky/USA; in 1986 and 1988 the human herpesvirus 6 (HHV 6) was discovered as the causative agent of the disease and serologic tests were established for diagnostics (specific IgM and IgG antibodies). "
6.	Polychlorinated Biphenyls (PCBs)IBA 08/01/2011 - "Prenatal exposure to PCBs and dioxins was found to be associated with increased risk of wheeze and exanthema subitum, and also with increased frequency of upper respiratory tract infections. "
7.	PhytohemagglutininsIBA 06/01/2006 - "The lymphoproliferative response to phytohemagglutinin ratios implied that HHV-6 infection has some impact on host T-cell immunity during the course of exanthema subitum." 06/01/2006 - "The lymphoproliferative response to purified human herpesvirus 6 (HHV-6) antigen and to phytohemagglutinin was measured and natural killer (NK) cell activities determined in three consecutive specimens obtained biweekly from 18 young children and infants with exanthema subitum. "
8.	Penicillins (Penicillin)FDA Link 05/28/1971 - "[Penicillin allergy or exanthema subitum?]."
9.	Nalidixic AcidFDA Link 11/01/1983 - "In 8 patients the syndrome was precipitated by medications (sulfenazone - nalidixic acid); 3 had a prior history of 3 days of fever and roseola infantum, in 2 cases precipitanting factors were not found. "
10.	Lysine (L-Lysine)FDA Link 11/01/2021 - "It has a possible association with the HHV-6B virus (roseola infantum) and can be controlled by antivirals such as acyclovir as well as by the amino acid l-Lysine that showed a positive result in reducing the number of lesions and healing time. "

Therapies and Procedures

1.	Stem Cell Transplantation 03/01/2000 - "Two clinical observations, the association of human herpesvirus-6 (HHV-6) with delayed engraftment after stem cell transplantation and thrombocytopenia concomitant with exanthema subitum, prompted us to evaluate the suppressive effects of HHV-6 on thrombopoiesis in vitro. "
2.	Hematopoietic Stem Cell Transplantation 02/01/2014 - "Human herpesvirus 6 (HHV-6) causes exanthema subitum and is associated with symptomatic reactivations in immunocompromised patients, particularly after hematopoietic stem cell transplantation. "
3.	Therapeutics 10/01/2009 - "Human herpesvirus 6 (HHV-6) is a common pathogen among children, classically presenting as fever and rash that resolve without specific therapy (exanthem subitum or roseola infantum). "