Europium

An element of the rare earth family of metals. It has the atomic symbol Eu, atomic number 63, and atomic weight 152. Europium is used in the form of its salts as coatings for cathode ray tubes and in the form of its organic derivatives as shift reagents in NMR spectroscopy.

Networked: 131 relevant articles (4 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Jin, Dayong: 4 articles (10/2016 - 09/2006)
2.	Connally, Russell: 4 articles (06/2011 - 09/2006)
3.	Zhang, Li: 3 articles (03/2022 - 11/2007)
4.	Pettersson, Kim: 3 articles (01/2021 - 11/2010)
5.	Piper, James A: 3 articles (01/2020 - 03/2011)
6.	Sayyadi, Nima: 3 articles (01/2020 - 01/2016)
7.	Liu, Jikun: 3 articles (01/2019 - 12/2014)
8.	Piper, James: 3 articles (05/2008 - 09/2006)
9.	Lin, Jun: 2 articles (07/2021 - 01/2014)
10.	Wong, Ka-Leung: 2 articles (07/2021 - 10/2013)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2011 - "Biodistribution studies with Europium-labeled conjugate revealed a five fold higher uptake in tumors as compared to other tissues. " 11/08/2023 - "Targeted, Molecular Europium(III) Probes Enable Luminescence-Guided Surgery and 1 Photon Post-Surgical Luminescence Microscopy of Solid Tumors." 05/30/2023 - "An activatable nanoprobe based on nanocomposites of visible-light-excitable europium(III) complex-anchored MnO2 nanosheets for bimodal time-gated luminescence and magnetic resonance imaging of tumor cells." 10/04/2016 - "For all prepared conjugates, the europium chelate in conjunction with a gated autosynchronous luminescence detector (GALD) completely suppressed the cellular autofluorescence background to allow capture of vivid, high contrast images of immune-stained cancer cells." 04/01/2016 - "A new and facile method for rapidly and accurately achieving tumor targeting fluorescent images has been explored using a specifically biosynthesized europium (Eu) complex in vivo and in vitro. "
2.	Osteosarcoma (Osteogenic Sarcoma) 10/01/2017 - "In vitro cytotoxicity of NKG2D-CAR+ CD45RA- T cells against osteosarcoma was evaluated by performing conventional 4-hour europium-TDA release assays. " 11/21/2018 - "Design and Evaluation of Europium Containing Mesoporous Bioactive Glass Nanospheres: Doxorubicin Release Kinetics and Inhibitory Effect on Osteosarcoma MG 63 Cells." 11/18/2019 - "In this study cytotoxicity of scaffolds composed from poly (L-lactic acid) functionalized with nanohydroxyapatite (nHAp) and doped with europium (III) ions-10 wt % 3 mol % Eu3+: nHAp@PLLA was tested using human osteosarcoma cells: U-2 OS, Saos-2 and MG-63. " 11/18/2019 - "The Potential Selective Cytotoxicity of Poly (L- Lactic Acid)-Based Scaffolds Functionalized with Nanohydroxyapatite and Europium (III) Ions toward Osteosarcoma Cells." 02/02/2022 - "In this study, a mineral nanomedicine, europium-doped calcium fluoride (CaF2:Eu) nanoparticles (NPs), is developed to enhance the efficacy of adjuvant radiotherapy (i.e., surgical resection followed by radiotherapy) for tumor cell growth and metastasis of osteosarcoma. "
3.	Neoplasm Metastasis (Metastasis) 02/02/2022 - "In this study, a mineral nanomedicine, europium-doped calcium fluoride (CaF2:Eu) nanoparticles (NPs), is developed to enhance the efficacy of adjuvant radiotherapy (i.e., surgical resection followed by radiotherapy) for tumor cell growth and metastasis of osteosarcoma. " 06/01/2011 - "In this paper, an animal model of hepatic adenocarcinoma is used in demonstrating successful targeting of spleen metastases with generation 3 polyamidoamine 4-amino-1,8-naphthalimide dendrimer containing 8 europium ions (Eu-G3P4A18N) for luminescence imaging." 11/05/2010 - "We also incorporated europium complexes inside a polymer matrix to produce 140 nm diameter fluorescent-ferrite beads (FF beads), which emit at 618 nm. These FF beads were used for immunofluorescent staining for diagnosis of cancer metastases to lymph nodes during cancer resection surgery by labeling tumor cell epidermal growth factor receptor (EGFRs), and for the detection of brain natriuretic peptide (BNP)-a hormone secreted in excess amounts by the heart when stressed-to a level of 2.0 pg ml(-1). "
4.	Urinary Bladder Neoplasms (Bladder Cancer) 01/01/2020 - "We further demonstrate lifetime-multiplexed detection of prostate and bladder cancer cells stained with different europium probes. " 11/01/2022 - "Evaluation of terbium and europium chelates for the detection of urinary bladder cancer showed highest specificity among all methods and improved overall performance (characterized by AUC) compared to commercial urine-based rapid tests and cytology. " 01/01/2021 - "ITGA3 was detected directly from the urine of bladder cancer (BlCa) (n = 13) and benign prostatic hyperplasia (BPH) (n = 9) patients with the use of lectins coated on europium-doped-nanoparticles (Eu3+-NPs). "
5.	Osteoporosis 01/01/2019 - "Continuous improvement in ultimate stiffness and Young's modulus of femur shaft of rats was observed with the increase in the dose of nano-HAp from 25 to 100 μg/kg. Results strongly suggest that europium-doped nano-HAp is more effective for treating severe osteoporosis in humans. "

Related Drugs and Biologics

1.	Terbium
2.	Minerals
3.	Calcium Fluoride
4.	Ions
5.	Metals
6.	Ruthenium
7.	Manganese
8.	Iron
9.	Biomarkers (Surrogate Marker)
10.	Antibodies

Related Therapies and Procedures

1.	Adjuvant Radiotherapy
2.	Radiotherapy
3.	Photothermal Therapy
4.	Drug Therapy (Chemotherapy)
5.	Quantum Dots (Quantum Dot)