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Etretinate

An oral retinoid used in the treatment of keratotic genodermatosis, lichen planus, and psoriasis. Beneficial effects have also been claimed in the prophylaxis of epithelial neoplasia. The compound may be teratogenic.

Also Known As:

B10-9359; Ethyl Etrinoate; Ro 10-9359; Ro-10-9359; Tigason; Tigazon; B10 9359; B109359; Etrinoate, Ethyl; Ro 10 9359; Ro 109359; Ro109359; 2,4,6,8-Nonatetraenoic acid, 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-, ethyl ester, (all-E)-

Networked: 696 relevant articles (87 outcomes, 67 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Ozawa, Akira: 3 articles (04/2013 - 02/2003)
2.	Seishima, Mariko: 3 articles (01/2010 - 11/2005)
3.	Shimizu, Hiroshi: 2 articles (09/2015 - 01/2015)
4.	Suzuki, Shotaro: 2 articles (09/2015 - 01/2015)
5.	Nomura, Toshifumi: 2 articles (09/2015 - 01/2015)
6.	Ikeda, Takaharu: 2 articles (09/2014 - 02/2004)
7.	Furukawa, Fukumi: 2 articles (09/2014 - 02/2004)
8.	Shibuya, Yoshinao: 2 articles (01/2010 - 02/2008)
9.	Cohen, Philip R: 2 articles (01/2009 - 01/2002)
10.	Duvic, Madeleine: 2 articles (09/2006 - 01/2003)

Related Diseases

1.	Psoriasis (Pustulosis Palmaris et Plantaris) 09/01/1994 - "Etretinate has proven to be effective in the treatment of psoriasis. " 09/01/1985 - "After 4 weeks of etretinate therapy, the chemotaxis-stimulating ability of the sera from psoriasis patients was no longer significantly greater than that of the control sera. " 11/01/1983 - "Etretinate causes a significant reduction in neutrophil chemotaxis in pustular psoriasis patients and a less pronounced reduction in those with vulgar psoriasis." 11/01/1985 - "In a double-blind controlled study of patients with pustular psoriasis of palms and soles who were allocated at random to etretinate or placebo, we found that etretinate improved the condition as assessed by pustule count and overall clinical response. " 09/01/1993 - "Etretinate is effective for treating psoriasis and other keratinizing disorders. "
2.	Acne Vulgaris 01/01/1981 - "The findings with this model system suggest that any efficacy of Ro 10-9359 in the treatment of acne would be by some mode other than the inhibition of sebum production." 04/01/1990 - "Oddly enough, they are reminiscent of some of the side effects of etretinate, an agent prescribed in these severe forms of acne. " 09/01/1989 - "Cystic and comedonal acne: a side effect of etretinate therapy." 04/01/1988 - "Cystic acne in psoriatic patients undergoing etretinate therapy." 04/01/1982 - "Successful treatment of conglobate acne using oral retinoid Ro-10-9359."
3.	Body Weight (Weight, Body) 01/01/1982 - "Of this satisfactorily improved group, at least 41% were still in the same condition after 3 years on a maintenance dose of, on average, 0.3 mg/kg body weight etretinate daily and 20 g weekly of a relatively strong corticosteroid cream. " 11/01/2005 - "The total amount of etretinate administered was 2,410 mg over 191 days (41.9 mg/kg body weight, average 15.3 mg/day). " 10/01/2003 - "Our patient was treated by a relatively low dose (0.5 mg/kg body weight) of etretinate. " 11/01/1989 - "Maximum plasma concentrations occurred within 1.5-4.0 hr. Absorption lag-times ranged from 0.3-2.5 hr, whereas the apparent absorption first order half-times (t1/2ka) were within the range of 0.3-1.2 hr. As judged from the AUC-values corrected for dose and body weight a six-fold interindividual variation existed with regard to the systemic availability of etretinate. " 01/01/1988 - "One group of mice was treated with 2 mg of ethyl (all-trans)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl- 2,4,6,8-nonatetraenoate (etretinate)/kg body weight daily. "
4.	Darier Disease (Darier's Disease) 08/12/1981 - "It is concluded that Tigason is effective in Darier's disease." 01/01/1981 - "It is pointed out that with the development of Ro 10-9359, an efficient remedy for Darier's disease has become available for the first time." 11/01/1982 - "Histochemical study of enzyme activities during etretinate treatment of Darier's disease." 01/01/1981 - "Treatment of Darier's disease with an oral aromatic retinoid (Ro 10-9359): a clinical and light and electron microscopic study." 01/01/2004 - "Localized Darier's disease of the scalp: successful treatment with oral etretinate."
5.	Carcinoma (Carcinomatosis) 01/01/1983 - "Tigason was more effective in preventing the recurrence of grade 1 and 2 carcinoma than placebo. " 05/01/1989 - "These results suggest that the stimulation of the G1 + 0 phase by etretinate enhanced the cytotoxicity of the anticancer drugs, and that a combination of etretinate with these drugs was effective in treating malignant epithelial tumors." 01/01/1987 - "The number of epitheliomas which developed during treatment with etretinate was compared with the number of epitheliomas recorded during the months or years preceding this treatment or during trial periods without treatment. " 01/01/2003 - "The third child, treated with etretinate for 6 years, had developed 38 carcinomas. " 01/01/1983 - "The authors undertook a double blind study in a group of 20 patients of the possible effectiveness of etretinate in the prevention of recurrences of superficial tumours of the bladder (with the exception of class IV carcinomas). "

Related Drugs and Biologics

1.	Etretinate
2.	Isotretinoin (Accutane)
3.	Acitretin
4.	Cyclosporine (Ciclosporin)
5.	Retinoids
6.	Methotrexate (Mexate)
7.	Steroids
8.	Tretinoin (Retinoic Acid)
9.	Interferon-alpha (Interferon Alfa)
10.	Ficusin (Psoralen)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Phototherapy (Light Therapy)
3.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
4.	Oral Administration
5.	Drug Therapy (Chemotherapy)