Etomidate

08/01/2018 - "This study was designed to clarify which of the two injection techniques-slow injection or priming with etomidate-is more effective in reducing myoclonus. "
08/10/2023 - "This review included systematic reviews and meta-analyses of randomized controlled trials involving the use of pharmacologic interventions to reduce etomidate-induced myoclonus. "
08/01/2018 - "Comparison of priming versus slow injection for reducing etomidate-induced myoclonus: a randomized controlled study."
12/01/2015 - "Myoclonus (6 trials) and painful injection (4 trials) were commonest adverse effects with etomidate. "
05/01/2013 - "A descriptive study of myoclonus associated with etomidate procedural sedation in the ED."

01/01/2017 - "We were able to demonstrate that etomidate can be used effectively to control severe hypercortisolism in a lower dose than previously described."
08/01/2012 - "We suggest treatment protocols for the safe and effective use of etomidate in Cushing's syndrome."
10/01/2023 - "Etomidate in the treatment of Cushing syndrome."
01/01/2022 - "Pharmacological management of severe Cushing's syndrome: the role of etomidate."
01/01/2020 - "Etomidate has a special position as emergency medication in severe hypercortisolism. "

01/01/2018 - "The aim of this study was to investigate the underlying molecular mechanisms which lead to injection pain of aqueous etomidate formulations. "
06/01/2021 - "Pain due to etomidate was rated on a VAS from 1 (painless) to 3 (worst imaginable pain) and their information was recorded. "
04/01/2018 - "The patients were assessed for the presence and severity of etomidate induced vascular pain (EP) and EM while injecting etomidate and for the next 2 min, respectively. "
01/01/2018 - "Painfulness of different etomidate formulations was tested in a translational human pain model. "
01/01/2015 - "Pain was assessed on a four-point scale: 0 = no pain, 1 = mild pain, 2 = moderate pain and 3 = severe pain at the time of pretreatment and etomidate injection. "

02/01/1995 - "Limited protective effects of etomidate during brainstem ischemia in dogs."
04/01/1992 - "The cerebral protective effects of etomidate were evaluated in a model of incomplete forebrain ischemia. "
04/01/1992 - "An assessment of the cerebral protective effects of etomidate in a model of incomplete forebrain ischemia in the rat."
08/01/1998 - "The purpose of our studies was to test whether etomidate selectively augmented cerebral blood flow (CBF) to CDT during ischemia as an additional mechanism of neuroprotection. "
09/01/2020 - "Etomidate has been shown to reduce ischemia/reperfusion (I/R) injury in several tissues. "

02/01/2015 - "PubMed, Embase, and CENTRAL (Cochrane Central Register of Controlled Trials) were searched for randomized controlled trials (RCTs) and observational studies regarding the effect of single-dose etomidate on mortality in adults with sepsis. "
02/01/2015 - "Single-dose etomidate does not increase mortality in patients with sepsis: a systematic review and meta-analysis of randomized controlled trials and observational studies."
07/11/2014 - "The aim of this study was to investigate the association between the administration of a single dose of etomidate or an alternative induction regime ahead of major cardiac surgery and clinical outcome parameters associated with adrenal suppression and onset of sepsis. "
03/01/2013 - "Retrospective analyses of several trials suggest etomidate may be unsafe for intubation in patients with sepsis. "
11/01/2008 - "We identified 181 patients with sepsis who were intubated over the study period; 135 received etomidate and 46 received alternative agents or no induction agent. "