Etiocholanolone

The 5-beta-reduced isomer of ANDROSTERONE. Etiocholanolone is a major metabolite of TESTOSTERONE and ANDROSTENEDIONE in many mammalian species including humans. It is excreted in the URINE.

Also Known As:

Networked: 79 relevant articles (3 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ohashi, Yoshiaki: 1 article (12/2013)
2.	Nishizaki, Yasuhiro: 1 article (12/2013)
3.	Hashimoto, Etsuko: 1 article (12/2013)
4.	Sato, Takaya: 1 article (12/2013)
5.	Taniai, Makiko: 1 article (12/2013)
6.	Tobari, Maki: 1 article (12/2013)
7.	Shiratori, Keiko: 1 article (12/2013)
8.	Kogiso, Tomomi: 1 article (12/2013)
9.	Matsushita, Noriko: 1 article (12/2013)
10.	Kodama, Kazuhisa: 1 article (12/2013)

Related Diseases

1.	Fever (Fevers) 07/20/1993 - "Etiocholanolone (ETC), a potent inflammatory agent, induces fever in humans and causes a decrease in the clearance of certain drugs that are metabolized by P450. " 11/10/1977 - "[Studies on etiocholanolone fever: Serum unconjugated eticholanolone concentration determined by radioimmunoassay]." 06/12/1992 - "["Etiocholanolone fever"?]." 06/01/1988 - "The patient's clinical and laboratory findings fulfilled diagnostic criteria for etiocholanolone fever (EF). " 06/01/1988 - "A case of periodic fever--reevaluation of etiocholanolone fever as an established clinical entity."
2.	Psoriasis (Pustulosis Palmaris et Plantaris) 01/01/1994 - "Quantitative and qualitative analysis of chromatograms in 40 patients and 30 controls permitted assessment of excretion of 17-ketosteroids, hydroxyandrosterone, etiocholanolone, androsterone, dihydroepiandrosterone, beta-cortol compounds, etc., which is important in studies of psoriasis pathogenesis and in assessment of the efficacy of treatment of this and other diseases."
3.	Leukocytosis (Pleocytosis) 07/01/1981 - " Usually, cases of etiocholanolone fever can be associated with symptoms such as elevated ESR, leukocytosis, myalgia, arthralgia, abdominal pain, diarrhea, and vomiting. " 08/01/1985 - "The subjects were fed a constant diet during each 4-day study and received three daily intramuscular injections of etiocholanolone, 0.10 mg/kg. Etiocholanolone injection resulted in inflammation, fever, leukocytosis, increased serum C-reactive protein, hypoferremia, and increased plasma activity of interleukin-1/lymphocyte-activating factor. "
4.	Inflammation 08/01/1985 - "The subjects were fed a constant diet during each 4-day study and received three daily intramuscular injections of etiocholanolone, 0.10 mg/kg. Etiocholanolone injection resulted in inflammation, fever, leukocytosis, increased serum C-reactive protein, hypoferremia, and increased plasma activity of interleukin-1/lymphocyte-activating factor. " 09/01/1980 - "Serum amyloid A proteins (SAA), presumed precursors of the tissue amyloid A proteins (AA) characteristic of secondary amyloidosis, have been isolated from the plasma high-density lipoproteins (HDL) of normals after etiocholanolone-induced inflammation and from patients with Wegener's granulomatosis, systemic lupus erythematosis, juvenile rheumatoid arthritis, Waldenström's macroglobulinemia, and Goodpasture's syndrome. "
5.	Seizures (Seizure) 01/01/2010 - "Activation of 5alpha-reductase pathway leads to formation of ketosteroid metabolites, primarily andosterone and etiocholanolone that demonstrate the ability to prevent convulsions in majority of animal studies. "

Related Drugs and Biologics

1.	Androsterone
2.	17-Ketosteroids (17 Ketosteroids)
3.	cortol
4.	Antipyrine (Phenazone)
5.	Hydrocortisone (Cortisol)
6.	Interleukin-1 (Interleukin 1)
7.	C-Reactive Protein
8.	Dehydroepiandrosterone (DHEA)
9.	Testosterone (Sustanon)
10.	Steroids

Related Therapies and Procedures

1.	Intramuscular Injections
2.	Mastectomy (Mammectomy)
3.	Aftercare (After-Treatment)