Ethynodiol Diacetate

A synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive (CONTRACEPTIVES, ORAL).

Also Known As:

(3 beta, 17 alpha)-19-Norpregn-4-en-20-yne-3,17 diol Diacetate; Continuin; Ethyndiol Diacetate; Ethynodiol Diacetate, (17 alpha)-Isomer; Femulen; 19-Norpregn-4-en-20-yne-3,17-diol, diacetate, (3beta,17alpha)-

Networked: 30 relevant articles (0 outcomes, 1 trials/studies)

Drug Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Norsteroids: 16
      - Norpregnanes: 2
        Norpregnenes
        Ethynodiol Diacetate: 30
        Bisecurin I: 21
        SC-11800 EE: 7
        ethynodiol: 3
        17-ethynyl-4-estrene-3,17-diol-3-acetate-17-(3'-acetoxy-2'-butenoate)
        ethynodiol testosterone ester

Related Diseases

1.	Ovarian Cysts (Ovarian Cyst) 04/01/1991 - "A total of 7,759 women were treated with ethynodiol diacetate, 1 mg, with ethinyl estradiol, 35 micrograms (EDA 1 mg with EE 35 micrograms) in a field study involving 983 obstetrician-gynecologists evaluating the incidence of ovarian cyst formation. " 04/01/1991 - "Incidence of ovarian cyst formation in women taking ethynodiol diacetate, 1 mg, with ethinyl estradiol, 35 micrograms."
2.	Metrorrhagia (Spotting) 01/01/1983 - " Femulen had no side effects, except for 2 cases of vaginal spotting. " 04/01/1991 - "A phase IV, open-label, multicenter survey of 983 obstetrician-gynecologists was conducted to evaluate the incidence of intermenstrual bleeding in 6,382 women receiving a low-dose monophasic oral contraceptive, ethynodiol diacetate, 1 mg, with ethinyl estradiol, 35 micrograms (EDA 1 mg with EE 35 micrograms) over a six-month period. " 06/18/1967 - "[The treatment of meno-metrorrhagia of functional origin by an estro-progestational compound: ethynodiol diacetate combined with mestranol]." 01/01/1983 - "Minimal alterations were seen with the levonorgestrel preparation, whereas those containing norethindrone or ethynodiol diacetate showed marked increases in factors I, VII, VIII and X and plasminogen, associated with a decrease in antithrombin III. Differences in the metabolic impact of the various commercially available low-estrogen preparations, combined with their effects on intermenstrual bleeding, allow a choice of the progestogen component most suitable for general use."
3.	Hemorrhage 01/01/1992 - "Continuin and Postinor pills are not safe, and they can produce irregular bleeding. " 01/01/1992 - " On the other hand, Continuin and Postinor did not prove reliable; they had frequent side effects such as irregular bleeding and extrauterine pregnancy (6.4%). " 09/01/1972 - " In order to induce periodic hemorrhage, 6 mg of the synthetic progestogen ethynodiol diacetate was added to the Quinestrol. " 11/01/1982 - " The progestogen-only formulation Femulen, with a daily dose of 5 mg of ethynodiol diacetate, has high efficacy and a relatively low dropout rate due to irregular bleeding and other causes."
4.	Breast Neoplasms (Breast Cancer) 10/01/1990 - " In 1988, it reported, however, an increased risk of breast cancer before age 45 in women who had no children and had an early menarche (13 years old), especially those who took the OCs Ovulen and Demulen (ethynodiol diacetate). " 02/01/1989 - " Similarly, analyses according to the specific progestin component in combination OCs (ethynodiol diacetate, norethindrone, norethindrone acetate, norethynodrel, and norgestrel) did not suggest an increased risk of breast cancer. " 05/01/1974 - "To determine the relationship of oral contraceptive use and breast cancer, 96 rhesus monkeys were administered either Enovid-E (2.5 mg norethynodrel and .1 mg mestranol) or Ovulen (1 mg ethynodiol diacetate and .1 mg mestranol) cyclically for 5 years at doses of 1, 10 and 50 times the human dose. "
5.	Uterine Hemorrhage (Uterine Bleeding) 02/01/1969 - "[Induction of uterine hemorrhage using 17-alpha-ethynyl-4-estrene-3-beta, 17-beta-diol diacetate (ethynodiol diacetate)]." 08/01/1970 - "[Double blind test for induction of uterine hemorrhage by Ovulen (ethynodiol diacetate 0.5mg+mestranol 1.1mg])]."

Related Drugs and Biologics

1.	Ethinyl Estradiol (Estinyl)
2.	Progestins (Progestagens)
3.	Mestranol
4.	Bisecurin I (Ovulen)
5.	Norgestrel (DL-Norgestrel)
6.	Norethynodrel
7.	Norethindrone (Norethisterone)
8.	Oral Contraceptives
9.	Ethynodiol Diacetate
10.	Chlormadinone Acetate (Chlormadinone)

Related Therapies and Procedures

1.	Therapeutics