Ethylmorphine-N-Demethylase

A drug-metabolizing enzyme of the hepatic microsomal oxidase system which catalyzes the oxidation of the N-methyl group of ethylmorphine with the formation of formaldehyde.

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Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Vitamin E Deficiency 12/01/1983 - "Vitamin E deficiency alone (0 ppm, saline pretreatment) produced a 37% increase in hepatic lipid peroxidation without any appreciable alteration in hepatic aniline hydroxylase, ethylmorphine N-demethylase or aryl hydrocarbon hydroxylase activities. "
2.	Vitamin A Deficiency 06/01/1976 - "Of the three microsomal enzymes studied, ethylmorphine N-demethylase, aniline hydroxylase, and aminopyrine N-demethylase, only the last one was adversely affected by vitamin A deficiency. "
3.	Inflammation (Inflammations) 04/01/1991 - "Carrageenan-induced inflammation and exposure to endotoxin considerably decreased the content of cytochrome P-450 and activities of ethylmorphine N-demethylase and meperidine N-demethylase, but did not decrease the activities of aniline hydroxylase or NADPH-cytochrome c reductase, compared with the respective activities in rats treated with carrageenan alone. "
4.	Body Weight (Weight, Body) 05/01/1985 - "The nursing rat pups of mothers exposed to DEHP showed decreases in body weight gain and activities of aniline hydroxylase, ethylmorphine N-demethylase, and arylhydrocarbon hydroxylase and decreased levels of cytochrome P-450 at 21 days of age. "

Related Drugs and Biologics

1.	Aniline Hydroxylase
2.	Mixed Function Oxygenases (Monooxygenases)
3.	Cytochrome P-450 Enzyme System (Cytochrome P450)
4.	NADPH-Ferrihemoprotein Reductase (Cytochrome P450 Reductase)
5.	Hydrocarbons
6.	Enzymes
7.	Endotoxins
8.	Diethylhexyl Phthalate (DEHP)
9.	Carrageenan
10.	Aminopyrine N-Demethylase