Ethylene Oxide (Oxirane)

A colorless and flammable gas at room temperature and pressure. Ethylene oxide is a bactericidal, fungicidal, and sporicidal disinfectant. It is effective against most micro-organisms, including viruses. It is used as a fumigant for foodstuffs and textiles and as an agent for the gaseous sterilization of heat-labile pharmaceutical and surgical materials. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p794)

Also Known As:

Networked: 393 relevant articles (4 outcomes, 37 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lavasanifar, Afsaneh: 4 articles (08/2011 - 10/2005)
2.	Langer, Robert: 4 articles (07/2011 - 09/2005)
3.	Valdez-Flores, Ciriaco: 3 articles (10/2011 - 10/2009)
4.	Sielken, Robert L: 3 articles (10/2011 - 10/2009)
5.	Kabanov, Alexander V: 3 articles (05/2010 - 01/2005)
6.	Mahmud, Abdullah: 3 articles (11/2008 - 10/2005)
7.	Amiji, Mansoor M: 3 articles (05/2008 - 04/2005)
8.	Shenoy, Dinesh: 3 articles (03/2007 - 09/2005)
9.	Amiji, Mansoor: 3 articles (03/2007 - 09/2005)
10.	Little, Steven: 3 articles (03/2007 - 09/2005)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2011 - "The findings from this updated study indicate limited or low risks for human cancer due to occupational exposure from ethylene oxide at the low cumulative exposure levels in this cohort. " 04/01/2010 - "The most recent epidemiological data on individual workers in the NIOSH and updated UCC occupational studies have been used to characterize the potential excess cancer risks of environmental exposure to ethylene oxide (EO). " 09/01/2000 - "Long-term inhalation studies in rodents have presented unequivocal evidence of experimental carcinogenicity of ethylene oxide, based on the formation of malignant tumors at multiple sites. " 04/01/1995 - "Cytogenetic changes associated with ethylene oxide (ETO) exposure at a worksite prompted a study of cancer incidence in that cohort. " 03/01/1990 - "A multicentre cohort study was carried out to study the possible association between exposure to ethylene oxide and cancer mortality. "
2.	Infection 05/01/2005 - "Poly(ethylene oxide) (PEO) coatings have been shown to reduce the adhesion of different microbial strains and species and thus are promising as coatings to prevent biomaterial-centered infection of medical implants. " 11/01/1990 - "In five patients, the same generator unit was successfully reimplanted following ethylene oxide sterilization without infection recurrence. " 12/01/2004 - "The low infection rate confirms the efficacy of ethylene oxide as a reliable option for sterilization of bone allograft, and it is also cost effective." 11/01/1988 - "It is concluded that careful cleaning, disinfection, and resterilization of intravascular catheters with ethylene oxide does not increase the risk of infection. " 05/28/2013 - "We describe here the development and study of poly(ethylene oxide)-polycaprolactone polymersomes designed to interact with influenza viruses at two different stages in the infection process. "
3.	Ovarian Neoplasms (Ovarian Cancer) 03/01/2007 - "Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: part 3. Therapeutic efficacy and safety studies in ovarian cancer xenograft model."
4.	Crush Syndrome 05/01/2004 - "Polyetox, a medicinal form of high-molecular-weight poly(ethylene oxide) (HMWPEO) improved peripheral blood supply, normalized the overall oxygen consumption, decreased erythrocyte aggregation, and reduced blood viscosity at low shear rate, and restored the antiturbulent properties (hydrodynamic index) of blood in the experiments on rats with crush syndrome. "
5.	Leukemia 05/01/1997 - "The failure of several larger studies to replicate the early Swedish findings of a very strong association between leukemia and ethylene oxide has not been adequately explained. " 11/01/1981 - "Because of reports linking an increased risk of leukemia with exposure to ethylene oxide, a mortality study of workers with potential exposure to ethylene oxide at the Texaco Chemical Company Plant in Port Neches, Tex., was undertaken. " 05/01/1987 - "Ethylene oxide and leukemia." 03/28/1986 - "Eight cases of leukemia have occurred among 733 ethylene oxide-exposed workers compared with an expected 0.8 cases. " 05/16/1991 - "Studies in Sweden have shown an excess of leukemia and stomach cancer in humans exposed to ethylene oxide, but other studies have generally failed to confirm these findings. "

Related Drugs and Biologics

1.	poly(beta-amino ester)
2.	poly(lactide) (polylactide)
3.	Cisplatin (Platino)
4.	Benzene (Benzole)
5.	propylene oxide
6.	polycaprolactone
7.	Immunoglobulin E (IgE)
8.	Serum Albumin
9.	Polymers
10.	Sodium

Related Therapies and Procedures

1.	Homologous Transplantation (Allograft)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Drug Therapy (Chemotherapy)
4.	Renal Dialysis (Hemodialysis)
5.	Bone Plates (Bone Plate)