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Ethyl Methanesulfonate

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An antineoplastic agent with alkylating properties. It also acts as a mutagen by damaging DNA and is used experimentally for that effect.

Also Known As:

Ethyl Mesilate; Ethyl Mesylate; Ethylmesilate; Ethylmesylate; Mesilate, Ethyl; Mesylate, Ethyl; Methanesulfonate, Ethyl; Sulfonate, Ethylmethane; Ethylmethane Sulfonate; Methanesulfonic acid, ethyl ester

Networked: 98 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Matsumoto, Kyomu: 1 article (10/2015)
2.	Niimi, Naoko: 1 article (10/2015)
3.	Honma, Masamitsu: 1 article (10/2015)
4.	Adachi, Noritaka: 1 article (10/2015)
5.	Grúz, Petr: 1 article (10/2015)
6.	Nohmi, Takehiko: 1 article (10/2015)
7.	Suzuki, Tetsuya: 1 article (10/2015)
8.	Kanemaru, Yuki: 1 article (10/2015)
9.	Seshashayee, M: 1 article (01/2015)
10.	Singh, K: 1 article (01/2015)

Related Diseases

1.	Lymphoma (Lymphomas) 03/01/2002 - "Previous results from this laboratory showed supra-additivity for the induction of micronuclei in p53-mutated mouse lymphoma L5178Y cells after combined treatment with gamma-radiation from a 137Cs source and ethyl methanesulfonate (EMS). " 05/01/2000 - "Supra-additive genotoxicity of a combination of gamma-irradiation and ethyl methanesulfonate in mouse lymphoma L5178Y cells." 10/01/1982 - "M12.4, one of several B lymphomas derived from BALB/c mice, was mutagenized with ethyl methanesulfonate in vitro. " 02/01/1980 - "Molecular dosimetry of the chemical mutagen ethyl methanesulfonate: quantitative comparison of mutation induction in Escherichia coli, V79 Chinese hamster cells and L5178Y mouse lymphoma cells, and some cytological results in vitro and in vivo." 01/01/1998 - "To analyze specific genes related to radiation-induced apoptosis, 12 apoptosis-resistant clones were isolated from cells of the radiosensitive mouse thymic lymphoma 3SB line after treatment with ethyl methanesulfonate. "
2.	Body Weight (Weight, Body) 11/12/2009 - "In this subacute toxicity study, ethyl methanesulfonate (EMS) was administered daily by oral gavage to SPF-bred Wistar rats of both sexes at dose levels of 20, 60 and 180/120 mg/kg body weight (bw)/day for a period of 28 days (for 19 days in the high-dose group). " 01/01/1988 - "Groups of five male HA (ICR) mice were injected intraperitoneally with 60, 150, 300, or 600 mg/kg body weight of ethyl methanesulfonate (EMS) or with saline vehicle. " 12/01/1984 - "No synergistic effects could be demonstrated in somatic and germ cells of mice given a combined treatment of arsenic trioxide solution (As2O3, 12 mg per kg body weight) or of mercuric chloride solution (HgCl2, 6 mg per kg body weight) with ethylmethane sulfonate (EMS, 200 mg per kg body weight)." 01/08/2008 - "Female C57BL6 mice were infected with Plasmodium berghei (ANKA) and treated (ip route) with cyclophosphamide (CPA, 25 mg/kg body weight), 7,12-dimethylbenz[a]anthracene (DMBA, 50mg/kg body weight) or ethyl methanesulfonate (EMS, 150 mg/kg body weight), on post-infection days 9-12 when parasitemia was > or =9% of RBC. "
3.	Fetal Death 02/01/1989 - "Earlier studies in this laboratory revealed that ethylene oxide (EtO) or ethyl methanesulfonate (EMS) induced high frequencies of midgestation and late fetal deaths, and of malformations among some of the surviving fetuses, when female mice were exposed at the time of fertilization of their eggs or during the early pronuclear stage of the zygote. " 09/01/1991 - "Exposure of mouse zygotes to ethylene oxide (EtO) or ethyl methanesulfonate (EMS) led to high incidences of fetal death and of certain classes of fetal malformations (Generoso et al., 1987, 1988; Rutledge and Generoso, 1989). "
4.	Leukemia 05/01/2004 - "In this study, we compared the cytotoxicity of bifunctional busulfan with that of monofunctional ethyl methanesulfonate (EMS) in human promyelocytic leukemia HL-60 cells. "
5.	Dehydration (Water Stress) 01/01/2015 - "In the current study, we report a mutant, enhanced water stress tolerant1 (ewst1) with enhanced water stress tolerance, identified from the ethyl methanesulfonate-induced mutant population of rice variety Nagina22 by field screening followed by withdrawal of irrigation in pots and hydroponics (PEG 6000). "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Ethylene Oxide (Oxirane)
3.	Polyethylene Glycols (Polyethylene Glycol)
4.	Busulfan (Busulfex)
5.	Methyl Methanesulfonate
6.	Mitomycin (Mitomycin-C)
7.	Methylnitronitrosoguanidine (MNNG)
8.	Alkylating Agents
9.	Thioguanine (Tioguanine)
10.	Azacitidine (5 Azacytidine)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Subcutaneous Injections