Ethionine

2-Amino-4-(ethylthio)butyric acid. An antimetabolite and methionine antagonist that interferes with amino acid incorporation into proteins and with cellular ATP utilization. It also produces liver neoplasms.

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Networked: 384 relevant articles (2 outcomes, 36 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Knight, Belinda: 3 articles (01/2009 - 08/2005)
2.	Choi, Steve S: 2 articles (05/2010 - 12/2007)
3.	Yamamura, Ken-ichi: 2 articles (05/2010 - 01/2010)
4.	Diehl, Anna Mae: 2 articles (05/2010 - 12/2007)
5.	Araki, Kimi: 2 articles (05/2010 - 01/2010)
6.	Ozaki, Nobuyuki: 2 articles (05/2010 - 01/2010)
7.	Ohmuraya, Masaki: 2 articles (05/2010 - 01/2010)
8.	Omenetti, Alessia: 2 articles (05/2010 - 12/2007)
9.	Hirota, Masahiko: 2 articles (05/2010 - 01/2010)
10.	Baba, Hideo: 2 articles (05/2010 - 01/2010)

Related Diseases

1.	Necrosis 09/01/2003 - "d,l-Ethionine produces pancreatic exocrine necrosis and islet proliferation in hamsters and dogs. " 01/01/2003 - "Pancreatic tissue in the control group showed marked infiltration of inflammatory cells, and acinar cell necrosis was widespread 1 day after the last injection of ethionine (day 1). " 08/01/2002 - "d,l-Ethionine produces pancreatic exocrine necrosis and islet proliferation in hamsters and dogs. " 01/01/2002 - "To determine whether induction of pancreatic necrosis and islet proliferation by d,l-ethionine has potential for treating dogs with beta-cell insufficiency. " 04/01/1982 - "Pancreatic effects of ethionine: blockade of exocytosis and appearance of crinophagy and autophagy precede cellular necrosis."
2.	Carcinoma (Carcinomatosis) 11/01/1981 - "Ethionine causes hepatic carcinoma in rats after prolonged feeding but is not a mutagen in the Ames test. " 12/01/1956 - "Carcinoma of the liver in rats fed ethionine." 11/01/2010 - "Age dependence of oval cell responses and bile duct carcinomas in male fischer 344 rats fed a cyclic choline-deficient, ethionine-supplemented diet." 06/01/2000 - "Differentiation status of rat ductal cells and ethionine-induced hepatic carcinomas defined with surface-reactive monoclonal antibodies." 09/01/1993 - "Most of these animals died before they had consumed the choline-free diet with 0.1% ethionine for 12 mo. Rats in this group (96%) exhibited large and numerous cholangiofibrotic lesions, but hepatocellular nodules and carcinoma were not detected. "
3.	Cholestasis 10/01/1990 - "Serum activities of AP, gamma-GT, G1DH and GPT in the first four days after bile duct obstruction and ethionine in the rat." 01/01/1990 - "Because the differences between the groups with and without ethionine were not significant with the exception of AP, it is concluded that in the early phase of bile duct obstruction up to 24 h no influence of de novo-protein synthesis can be demonstrated in the elevation of the activities of gamma-GT, GlDH and GPT." 01/01/1990 - "One half of each group received the protein synthesis inhibitor ethionine, 24 h after bile duct obstruction in the group with ethionine the following enzyme activities were measured in the serum: AP 216 +/- 80 U/l; gamma-GT 4.5 +/- 1.9 U/l; GlDH 85 +/- 26 U/l; GPT 375 +/- 163 U/l. " 01/01/1990 - "The serum activities of AP, gamma-GT, GlDH and GPT after bile duct obstruction and ethionine in the rat." 10/01/1990 - "Following sham operation and bile duct obstruction (BDO), Wistar rats received ethionine, which inhibits protein synthesis in the liver. "
4.	Adenocarcinoma 08/01/2002 - "In the N-nitrosobis(2-oxopropyl)amine-induced model of ductal adenocarcinoma in hamsters, the latent period for induction of carcinomas has been dramatically reduced by the intermittent feeding of a choline-deficient diet combined with ethionine treatment. " 12/07/1988 - "Adenocarcinomas were induced in 84% of treated animals by 10 weeks after initiation with 70 mg of N-nitroso-bis(2-oxopropyl)amine (BOP) per kg of body weight when augmentation pressure (choline-deficient diet combined with DL-ethionine and L-methionine and administration of 20 mg/kg BOP upon return to basal diet) was applied three times. "
5.	Fatty Liver 09/01/1974 - "Studies on metabolism in rats with ethionine-induced fatty liver." 01/01/1967 - "Studies on ethionine-induced fatty liver." 06/01/1965 - "[Further studies on the prevention of the acute fatty liver induced by ethionine. " 05/01/1965 - "[FURTHER STUDIES ON THE PREVENTION OF THE ACUTE FATTY LIVER INDUCED BY ETHIONINE. " 04/01/1965 - "[FURTHER STUDIES ON THE PREVENTION OF THE ACUTE FATTY LIVER INDUCED BY ETHIONINE. "

Related Drugs and Biologics

1.	Choline (Choline Chloride)
2.	Carbon Tetrachloride (Tetrachloromethane)
3.	Cyclosporine (Ciclosporin)
4.	Biological Markers (Surrogate Marker)
5.	Ticlopidine (Ticlid)
6.	Tetracycline (Achromycin)
7.	Methapyrilene (Dormin)
8.	Flutamide (Eulexin)
9.	Carbamazepine (Tegretol)
10.	Acetaminophen (Paracetamol)

Related Therapies and Procedures

1.	Injections
2.	Protein-Restricted Diet (Diet, Protein Restricted)
3.	Drug Therapy (Chemotherapy)
4.	Intraperitoneal Injections
5.	Ligation