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Ethiodized Oil (Ethiodol)

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Ethyl ester of iodinated fatty acid of poppyseed oil. It contains 37% organically bound iodine and has been used as a diagnostic aid (radiopaque medium) and as an antineoplastic agent when part of the iodine is 131-I. (From Merck Index, 11th ed)

Also Known As:

Ethiodol; Lipiodol; Aspen Brand of Ethiodized Oil; Ethiodized Oil (Injection); Ethiodized Oils; Ethiodized Poppy Seed Oil; Guerbet Brand of Ethiodized Oil; Lipiodol UltraFluid; Savage Brand of Ethiodized Oil; Therapex Brand of Ethiodized Oil; Oil, Ethiodized; Oils, Ethiodized; UltraFluid, Lipiodol

Networked: 1331 relevant articles (109 outcomes, 168 trials/studies)

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Drug Context: Research Results

Experts

1.	Garin, Etienne: 10 articles (03/2012 - 10/2004)
2.	Chung, Jin Wook: 9 articles (09/2015 - 11/2002)
3.	Jeong, Jae Min: 9 articles (03/2015 - 10/2003)
4.	Raoul, Jean-Luc: 8 articles (06/2011 - 11/2003)
5.	Morris, D L: 8 articles (01/2008 - 03/2000)
6.	Matsui, Osamu: 7 articles (04/2014 - 11/2006)
7.	Chen, Yong: 7 articles (09/2013 - 10/2003)
8.	Park, Jae Hyung: 7 articles (06/2013 - 11/2002)
9.	Kim, Hyo-Cheol: 6 articles (09/2015 - 11/2009)
10.	Sato, Morio: 6 articles (08/2015 - 06/2010)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 06/01/2005 - "Adjuvant iodine-131-labeled lipiodol for prevention of intrahepatic recurrence of hepatocellular carcinoma: which is the best treatment schedule?" 04/01/1988 - "Lipiodol-computed tomography is very effective in the diagnosis of daughter nodules of hepatocellular carcinoma." 04/01/2010 - "To evaluate the safety and efficacy of transcatheter arterial chemo-lipiodol infusion (TACL) in high-risk patients with unresectable hepatocellular carcinoma (HCC). " 04/01/1989 - "[A case of hepatoma treated successfully with a percutaneous intratumoral injection of CDDP-PC-lipiodol suspension]." 01/01/2008 - "In this prospective randomized trial, we attempted to find out if 1 dose of postoperative adjuvant intra-arterial iodine-131-labeled lipiodol could reduce the rate of local recurrence, and increase disease-free and overall survival for patients with hepatocellular carcinoma (HCC). "
2.	Neoplasms (Cancer) 03/01/2008 - "The degree of Lipiodol retention within the tumor in Group A was significantly greater than that in Groups B and C on day 14 (p = 0.014) and day 28 (p = 0.013). " 11/01/1997 - "In terms of patient survival and tumor response, radioactive 131I-labeled Lipiodol and chemoembolization were equally effective in the treatment of HCC, but tolerance to 131I-labeled Lipiodol was significantly better." 01/01/1995 - "Microscopically, the necrotic-area ratio of the tumors in the TNF/lipiodol emulsion-treated group was also significantly greater than in any other group (p < 0.01). " 02/01/1989 - "For the cases received lipiodol injection before radiation, lipiodol collection to the tumor was beneficial for the determination of the irradiated field." 06/01/2010 - "In conclusion, MRI is superior to MDCT for detection of viable tumor residuals after Lipiodol-based TACE. "
3.	Liver Neoplasms (Liver Cancer) 03/01/2015 - "The newly synthesized (188)Re-HDD/lipiodol showed improved radiolabeling yield and biodistribution results compared to (188)Re-HTDD/lipiodol, and may therefore be more suitable for liver cancer therapy." 07/01/2010 - "Reported CR ratio of definitely hypervascular HCC are around 30-60% by superselective TACE with Lipiodol for hypervascular HCC less than 5 cm. According to a nationwide survey by the Liver Cancer Study Group of Japan (LCSGJ), overall 5-year survival rate was 26% in patients with HCCs not indicated for surgery or RFA (PEI), mainly treated by segmental or subsegmental TACE using Lipiodol. " 03/01/2008 - "The Nuclear Medicine Section of IAEA's Division of Human Health initiated the first Doctoral CRP of IAEA in the year 2000, entitled, "Management of Liver Cancer Using Radionuclide Methods with Special Emphasis on Trans-Arterial Radio-conjugate Therapy and Internal Dosimetry." Since then, the CRP has accomplished several milestones, including development of a new therapeutic radiopharmaceutical ((188)Re lipiodol) and successfully carrying out Phase I and Phase II clinical trials on patients using the new therapeutic radiopharmaceutical." 01/01/2007 - "A lipiodol solution of (188)Re-4-hexadecyl-2,2,9,9-tetramethyl-4,7-diaza-1,10-decanedithiol ((188)Re-HDD/lipiodol) is in clinical study for liver cancer therapy. " 03/01/2015 - "A lipiodol solution of (188)Re-4-hexadecyl-2,2,9,9-tetramethyl-4,7-diaza-1,10-decanedithiol (HTDD) has been successfully developed for liver cancer therapy; however, its preparation requires a multi-step synthesis and it is characterized by a low labeling yield. "
4.	Neoplasm Metastasis (Metastasis) 09/01/1992 - "The tumour:liver ratio in the other three patients increased from 3.0-5.6:1 on day 1 to 4.5-7.2:1 on day 6. This study suggests that Lipiodol may be a useful therapeutic delivery agent to small colorectal liver metastases." 10/01/2010 - "The size of liver metastases and the percentage of Lipiodol uptake may help identify patients likely to benefit most from transcatheter arterial chemoembolization." 10/01/2010 - "Higher response rates were observed in cases in which the diameter of the target metastasis was 3 cm or smaller (P = .002) and in cases of high Lipiodol uptake (> 50%; P < .0001). " 10/01/2010 - "The size of liver metastases, percentage of liver involvement, and Lipiodol uptake were studied as potential predictive factors of response. " 07/01/2001 - "These findings suggest that helical CT is superior in delineating early HCC, whereas Lipiodol CT is specific to the detection of intrahepatic metastases. "
5.	Carcinoma (Carcinomatosis) 01/01/2014 - "For the in-vivo study, 15 rabbits bearing VX2 carcinoma in the liver were treated with 4∶1 volume ratio Lipiodol emulsion (group A), 1∶1 volume ratio Lipiodol emulsion (group B), and DEBs (group C) chemoembolization. " 01/01/2014 - "Computed tomography lymphography using ethiodized oil may be feasible for sentinel node mapping in experimentally induced VX2 carcinoma in the rabbit thigh." 01/01/2014 - "Twenty-three rabbits with VX2 carcinoma in the thigh underwent CT before and after (1 hour, 2 hour) peritumoral injection of 2 mL ethiodized oil. " 01/01/2014 - "To assess the feasibility of computed tomography (CT) lymphography using ethiodized oil for sentinel node mapping in experimentally induced VX2 carcinoma in the rabbit thigh. " 01/01/2014 - "Sentinel node mapping of VX2 carcinoma in rabbit thigh with CT lymphography using ethiodized oil."

Related Drugs and Biologics

1.	Cisplatin (Platino)
2.	Ethanol (Ethyl Alcohol)
3.	Epirubicin (Ellence)
4.	Ethiodized Oil (Ethiodol)
5.	poly(maleic acid-styrene)neocarzinostatin (zinostatin stimalamer)
6.	Doxorubicin (Adriamycin)
7.	Iodine
8.	Mitomycin (Mitomycin-C)
9.	Enbucrilate
10.	alpha-Fetoproteins (AFP)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Intra-Arterial Injections
3.	Catheters
4.	Palliative Care (Palliative Medicine)
5.	Absorbable Gelatin Sponge