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Ethinyl Estradiol (Estinyl)

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A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.

Also Known As:

Estinyl; Lynoral; Effik Brand of Ethinyl Estradiol; Ethinyl Estradiol Hemihydrate; Ethinyl Estradiol, (8 alpha)-Isomer; Ethinyl Estradiol, (8 alpha,17 alpha)-Isomer; Ethinyl Estradiol, (8 alpha,9 beta,13 alpha,14 beta)-Isomer; Ethinyl Estradiol, (9 beta,17 alpha)-Isomer; Ethinyl-Oestradiol Effik; Ethinylestradiol Jenapharm; Ethinyloestradiol; Jenapharm Brand of Ethinyl Estradiol; Microfollin; Microfollin Forte; Organon Brand of Ethinyl Estradiol; Progynon C; Schering Brand of Ethinyl Estradiol; Schering-Plough Brand of Ethinyl Estradiol; Estradiol, Ethinyl; Estradiol, Ethynyl; Ethinyl Oestradiol Effik; Hemihydrate, Ethinyl Estradiol; Jenapharm, Ethinylestradiol; Ethynyl Estradiol; 19-Norpregna-1,3,5(10)-trien-20-yne-3,17-diol, (17alpha)-

Networked: 696 relevant articles (48 outcomes, 123 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Archer, David F: 6 articles (01/2016 - 02/2008)
2.	Jensen, Jeffrey T: 5 articles (10/2014 - 01/2003)
3.	Taneepanichskul, Surasak: 5 articles (01/2013 - 03/2007)
4.	Weisberg, Edith: 4 articles (12/2014 - 07/2005)
5.	Westhoff, Carolyn L: 4 articles (02/2014 - 06/2005)
6.	Stanczyk, Frank Z: 4 articles (06/2013 - 09/2002)
7.	Grimes, David A: 4 articles (01/2013 - 03/2005)
8.	Nanda, Kavita: 4 articles (01/2013 - 03/2005)
9.	Gallo, Maria F: 4 articles (01/2013 - 03/2005)
10.	Schulz, Kenneth F: 4 articles (01/2013 - 03/2005)

Related Diseases

1.	Acne Vulgaris 07/01/1953 - "Local and systemic use of ethinyl estradiol in patients with acne and hirsutism." 01/01/1981 - "37 women have received during a total of 429 cycles (mean 12 cycles/patients) an association containing cyproterone acetate 2 mg and ethinyl estradiol 0.05 mg. A marked improvement in the clinical symptoms (acne 35 cases) has been observed. " 10/01/2008 - "The low-dose combined oral contraceptive containing 3-mg drospirenone/20-microgram ethinyl estradiol administered in a 24/4 regimen significantly reduced acne lesion counts more effectively than placebo and demonstrated greater improvement in the Investigator Static Global Assessment rating of acne. " 06/01/2013 - "3mg Drospirenone (DRSP)/0.02 mg ethinyl estradiol (EE), an oral contraceptive and antiandrogen, has been effective in treatment studies of facial acne in women, but investigations on its efficacy for truncal acne are limited.<BR> In this study, we sought to evaluate the safety and efficacy of 3mg DRSP/0.02 mg EE versus placebo in the treatment of truncal acne in women.<BR> Females, age 18-45, with 10 to 50 truncal acne lesions, were randomized in this double-blind study to 3mg DRSP/0.02 mg EE (n=15) or placebo (n=10) administered in a 24/4 regimen given for 24 weeks. " 01/01/1999 - "In addition, the FDA has stated for the first time that an OC-triphasic norgestimate/35 micrograms ethinyl estradiol--is an effective treatment for moderate acne vulgaris. "
2.	Hirsutism 01/01/2007 - "This study prospectively compared the clinical and biochemical efficacy of 3 mg DRSP/30 microg ethinyl estradiol (EE) and 2 mg CPA/35 microg EE combinations in a total of 91 patients with hirsutism. " 07/01/1953 - "Local and systemic use of ethinyl estradiol in patients with acne and hirsutism." 02/01/2006 - "Drospirenone/ethinyl estradiol combination exerts significant antiandrogenic activity and is effective in improving facial hirsutism. " 02/01/2006 - "Efficacy of a new oral contraceptive containing drospirenone and ethinyl estradiol in the long-term treatment of hirsutism." 11/01/2011 - "A prospective randomized trial comparing low-dose ethinyl estradiol and drospirenone 24/4 combined oral contraceptive vs. ethinyl estradiol and drospirenone 21/7 combined oral contraceptive in the treatment of hirsutism."
3.	Hemorrhage 03/01/2005 - "This review of randomized controlled trials tested the hypothesis that COCs containing <or=20 microg ethinyl estradiol (EE) perform similarly to those containing >20 microg in terms of contraceptive effectiveness, bleeding patterns, discontinuation and side effects. " 01/01/2016 - "Our analysis of an ultra-low ethinyl estradiol dose COC did not find clinically important differences in contraceptive failure rates, adverse events or bleeding profile with increasing BMI. " 01/01/2013 - "To test the hypothesis that COCs containing ≤ 20 μg ethinyl estradiol (EE) perform similarly as those containing > 20 μg in terms of contraceptive effectiveness, bleeding patterns, discontinuation, and side effects. " 01/01/2011 - "To test the hypothesis that COCs containing ≤ 20 μg ethinyl estradiol (EE) perform similarly as those containing > 20 μg in terms of contraceptive effectiveness, bleeding patterns, discontinuation, and side effects. " 02/01/2008 - "This review focuses on a unique oral contraceptive formulation containing levonogestrel 90 microg and ethinyl estradiol 20 microg, approved for use in a continuous dosing regimen designed to eliminate withdrawal bleeding throughout the entire year."
4.	Hyperandrogenism 07/01/1995 - "twenty patients, affected by clinical manifestations of hyperandrogenism, were studied basally and during treatment with 10 mg of cyproterone acetate associated with ethynyl-estradiol (20 m g) in an inversal sequential scheme for six months. " 07/01/1995 - "to investigate the effects of treatment with low dose of cyproterone acetate and ethynyl-estradiol on chemical and hormonal parameters in female hyperandrogenism. " 04/01/1990 - "The metabolic effects of cyproterone acetate (2 mg) combined with a new dose level of ethinyl estradiol (35 micrograms) were studied over a one-year period in 31 patients presenting moderate clinical hyperandrogenism. " 10/01/2000 - "Oral contraceptive pills containing low-dose ethinyl estradiol and desogestrel are effective in controlling hyperandrogenism and hirsutism and ameliorate the abnormal metabolic profile of women with hirsutism." 03/01/2007 - "To investigate the efficacy of a combined oral contraceptive containing 30 microg ethinyloestradiol and 3 mg drospirenone in the treatment of hyperandrogenism affecting women with the polycystic ovary syndrome (PCOS). "
5.	Metrorrhagia (Spotting) 01/01/1946 - "Ethinyl estradiol in the treatment of metrorrhagia." 10/01/1996 - " Among this subgroup, only ethinyl estradiol alone reduced significantly (p 0.02) the number of bleeding/spotting days during the 21-day treatment period. " 10/01/1996 - " On average, women treated with ethinyl estradiol had their bleeding episode shortened by 1 bleeding day and 3 spotting days. " 05/01/2000 - "Despite a lower ethinyl estradiol dose (25 microg/day vs. 35 microg/day), the Cyclessa group had significantly improved cycle control in comparison to the Ortho-Novum 7/7/7 group for presence of a withdrawal bleed (p = 0.001), lack of early withdrawal bleed (p = 0.01), and breakthrough bleeding/spotting (p = 0.001). " 12/01/2000 - "To compare the efficacy of a triphasic combination oral contraceptive (OC) containing norgestimate and ethinyl estradiol (E2) and placebo in the treatment of metrorrhagic, menometrorrhagic, oligomenorrheic, and polymenorrheic dysfunctional uterine bleeding (DUB). "

Related Drugs and Biologics

1.	Levonorgestrel (Plan B)
2.	drospirenone
3.	Cyproterone Acetate
4.	norgestimate
5.	norethindrone acetate (Norlutate)
6.	Desogestrel
7.	Hormones
8.	Norethindrone (Norethisterone)
9.	ethynylestradiol mixture with norethindrone (Zoran)
10.	Estrogens (Estrogen)

Related Therapies and Procedures

1.	Oral Administration
2.	Heterologous Transplantation (Xenotransplantation)
3.	Female Contraceptive Devices (Vaginal Ring)
4.	Injections
5.	Ligation