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Ethamoxytriphetol
A non-steroidal estrogen antagonist.
Also Known As:
MER-25; MER 25; MER25; Benzeneethanol, alpha-(4-(2-(diethylamino)ethoxy)phenyl)-4-methoxy-alpha-phenyl-
Networked:
17
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Alcohols: 595
Ethanol: 23169
Ethamoxytriphetol: 17
MRL-37
Related Diseases
1.
Edema (Dropsy)
02/01/1975 - "
In the in vivo carrageenan-induced rat paw edema studies, diethylstilbestrol was more potent as an anti-inflammatory agent than was clomiphene, and ethamoxytriphetol and triparanol were only marginally effective.
"
2.
Lordosis
01/01/1981 - "
Rats treated with MER-25 and with SCN lesions showed high levels of mounting and lordosis behaviour throughout the light : darkness cycle.
"
01/01/1981 - "
Treatment with MER-25 enhanced the daily rhythmicity in both mounting and lordosis behaviour and SCN lesions disrupted these behavioural rhythms and the rhythm in the mounting behaviour of oil-treated rats.
"
04/22/1977 - "
However, when MER-25 was injected 12 hours prior to testing it inhibited retention of tritiated estradiol in brain and pituitary cell nuclei and lordosis response.
"
04/22/1977 - "
However, when MER-25 is injected 12 h prior to the estradiol, it inhibits retention of [3H]estradiol at 2 h in brain and pituitary cell nuclei, and lordosis responding is also inhibited.
"
03/01/1974 - "
Effects of an estrogen antagonist, MER-25, on mounting behavior and lordosis behavior in the female rat.
"
3.
Body Weight (Weight, Body)
02/01/1976 - "
MER-25 did not markedly alter the effects of EB on body weight and eating, but did antagonize the effects of EB on the uterus, vagina, and sex behavior.
"
02/01/1976 - "
Because of its full estrogenicity, MER-25 fails to antagonize the effects of EB on eating and body weight while simultaneously antagonizing effects of EB on sexual behavior, the uterus, and the vagina.
"
03/01/1980 - "
Serum P production rates (metabolic clearance rate [MCR] x peripheral serum concentration) were determined in baboons prior to and following maternal administration of the antiestrogen ethamoxytriphetol (MER-25) at 30, 15, 6, or 3 mg/kg of body weight by mouth daily for 10 or 20 day periods during or throughout the last one third of gestation.
"
02/01/1978 - "
Treatment of the neonatal rat with MER-25 reduced body weight in adulthood but did not change the weight of the accessory sexual glands, the testes, the number of cornified papillae on the glans penis or plasma testosterone concentrations during development.
"
02/01/1976 - "
Estradiol benzoate (EB) and MER-25 both had similar effects in gonadectomized rats, and produced a transient decrease in food consumption and a permanent decrease in body weight.
"
4.
Endometrial Neoplasms (Endometrial Cancer)
07/15/1990 - "
MER-25 is antiestrogenic in primates and was investigated in the clinics in a wide range of gynecological conditions, including breast and endometrial cancer.
"
5.
Weight Gain
02/01/1976 - "
As evidenced by its failure to cause an habitual aversion to saccharin and failure to alter spontaneous activity, MER-25 inhibited weight gain and eating.
"
02/01/1976 - "
The MER-25 causes decreases in eating and weight gain that are not due to toxicity, as indicated by its failure to induce a learned aversion to saccharin and by its failure to alter spontaneous activity.
"
Related Drugs and Biologics
1.
Triparanol
2.
Diethylstilbestrol (Stilbestrol)
3.
Clomiphene (Clomifene)
4.
Carrageenan
5.
Anti-Inflammatory Agents (Anti-Inflammatories)
6.
Estrogens (Estrogen)
7.
Estrogen Receptor Modulators (Antiestrogen)
8.
Progesterone
9.
Nafoxidine
10.
Estradiol (Delestrogen)
Related Therapies and Procedures
1.
Castration
2.
Injections