Estrone (Folliculin)

An aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.

Also Known As:

Networked: 984 relevant articles (11 outcomes, 110 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Stanczyk, Frank Z: 13 articles (10/2015 - 05/2003)
2.	Tworoger, Shelley S: 11 articles (10/2014 - 05/2003)
3.	Linehan, W Marston: 10 articles (03/2015 - 08/2002)
4.	Schmidt, Laura S: 10 articles (03/2015 - 08/2002)
5.	Kaaks, Rudolf: 10 articles (12/2014 - 12/2002)
6.	Hankinson, Susan E: 9 articles (10/2014 - 08/2005)
7.	Baba, Masaya: 8 articles (03/2015 - 10/2006)
8.	Lundin, Eva: 8 articles (12/2014 - 05/2003)
9.	Dowsett, Mitch: 8 articles (01/2014 - 10/2006)
10.	Lukanova, Annekatrin: 8 articles (04/2013 - 12/2002)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 07/01/2014 - "In this study, higher levels of 2-OHE1 were associated with reduced risk of ER+ breast cancer in postmenopausal women after adjustment for circulating estrone. " 05/15/2011 - "The mean estrone concentration determined by our ultrasensitive and highly specific assay was significantly lower than that reported for the control groups in most previous breast cancer studies of postmenopausal women. " 01/01/1996 - "This study reveals sharp contrasts in breast cancer risk between women with high estrone and low BMI and SHBG, vs women with low estrone and high BMI and SHBG." 01/01/2016 - "In breast cancer patients but not in the controls, breast adipose tissue estrone levels correlated positively with the serum estrone concentration. " 01/01/2016 - "The median concentration of estrone in subcutaneous adipose tissue from the breast did not differ between breast cancer and control women, 920pmol/kg and 890pmol/kg, respectively. "
2.	Liver Cirrhosis (Hepatic Cirrhosis) 09/01/1976 - "The absolute decrease of estrone was significantly greater in patients with hepatic cirrhosis than in healthy male subjects (35.5 +/- 12.6 vs. 21.3 +/- 6.0 pg/ml; P is less than 0.05; n: 8). " 09/01/1976 - "ACTH application resulted in a striking increase in plasma estrone levels in both patients with hepatic cirrhosis and in normal subjects (61.8 +/- 27.5 vs. 27.3 +/- 7.8 pg/ml). " 09/01/1976 - "Compared to controls, estradiol levels were moderately elevated by 26% (P is less than 0.05) in patients with hepatic cirrhosis (28.5 +/- 5.4 vs. 36.0 +/- 4.7 pg/ml plasma; n: 12), whereas estrone levels exhibited a two- to threefold increase under basal conditions (32.5 +/- 5.6 vs. 67.8 +/- 20.8 pg/ml; P is less than 0.01). " 09/01/1976 - "To study the influence of the adrenal gland on plasma estrogen levels in male patients with hepatic cirrhosis, estrone and estradiol were measured under a variety of experimental conditions. " 01/01/1980 - "For eight who were amenorrheic, with advanced liver cirrhosis and ascites, the reduction of testosterone and rise in estrone and sex hormone binding globulin concentrations were significant. "
3.	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 01/01/1980 - "Metabolism of estrone sulphate by benign prostatic hyperplasia in vitro." 01/01/1981 - "12 male subjects, 6 with congestive prostatis and 6 with benign prostatic hypertrophy, were treated with a combination of 3 levonorgestrel rods and 3 estrone rods. " 01/01/1980 - "Benign prostatic hyperplasia concentrated dihydrotestosterone, estradiol-17 beta, and estrone at levels significantly greater than those found in normal prostate or male plasma. " 01/01/1985 - "It has been shown that progesterone, estrone, and estradiol are present in significant amounts in the human benign prostatic hyperplasia (BPH). " 01/01/1985 - "Inhibition of androgen metabolism in stroma and epithelium of the human benign prostatic hyperplasia by progesterone, estrone, and estradiol."
4.	Postmenopausal Osteoporosis 01/01/1952 - "Treatment of post-menopausal osteoporosis with estrone micro-crystal precipitates." 11/01/1989 - "The levels of estradiol, estrone, androstendione, and testosterone were investigated in 25 women aged 56-69 with postmenopausal osteoporosis and in healthy women using radioimmunoassays. " 09/01/2003 - "Thus, we studied 36 women with vertebral fractures due to typical high turnover type I postmenopausal osteoporosis and 36 normal postmenopausal women using new ultrasensitive assays with detection limits of 1 pg/ml for estradiol, 5 pg/ml for estrone and 5 ng/dl for testosterone to test if type I osteoporosis results from enhanced responsiveness of bone to estrogen deficiency. " 07/01/1996 - "In an attempt to define the efficacy of hormone replacement therapy in postmenopausal osteoporosis, we investigated the effects of estrone with or without medroxyprogesterone acetate on the bone mineral density of the femur of aged rats, of which plasma levels of luteinizing hormone (LH), follicle stimulating hormone (FSH) and estradiol were markedly reduced in comparison with those of younger rats. "
5.	Threatened Abortion 08/01/1988 - "Urinary estrone glucuronide, pregnanediol glucuronide and human chorionic gonadotrophin in threatened abortion." 01/01/1974 - "The relationship between urinary estrone and human chorionic gonadotropin (HCG) excretion and the prognosis in pregnancies complicated by threatened abortions was analyzed in 332 patients from 1968-1970 in Helsinki. " 01/01/1974 - "The predictive efficacy of plasma level tests of progesterone, human placental lactogen (HPL) activity, serum protein-bound iodine (S-PBI), and triiodothyronine uptake, and urinary levels of estrone and human chorionic gonadotropin (HCG) in evaluating the outcome of pregnancy in 75 cases of threatened abortion between Weeks 7-26 of pregnancy was studied. "

Related Drugs and Biologics

1.	Estradiol (Estrace)
2.	Estrogens (Estrogen)
3.	Testosterone (Sustanon)
4.	estrone sulfate (Evex)
5.	Estriol (Epiestriol)
6.	Androgens
7.	Sex Hormone-Binding Globulin
8.	Dehydroepiandrosterone Sulfate
9.	Hormones
10.	Prolactin

Related Therapies and Procedures

1.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
2.	Adrenalectomy
3.	Hypophysectomy
4.	Injections
5.	Estrogen Replacement Therapy