Esters

Compounds derived from organic or inorganic acids in which at least one hydroxyl group is replaced by an –O-alkyl or another organic group. They can be represented by the structure formula RCOOR’ and are usually formed by the reaction between an acid and an alcohol with elimination of water.

Also Known As:

Networked: 5855 relevant articles (253 outcomes, 666 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tang, Rupei: 19 articles (11/2021 - 04/2011)
2.	Wang, Xin: 19 articles (11/2021 - 06/2011)
3.	Beadle, James R: 19 articles (10/2018 - 01/2004)
4.	Molven, Anders: 18 articles (01/2022 - 02/2007)
5.	Hostetler, Karl Y: 18 articles (10/2018 - 01/2004)
6.	Gylling, Helena: 14 articles (08/2020 - 03/2003)
7.	Maki, Kevin C: 13 articles (01/2022 - 07/2007)
8.	Njølstad, Pål R: 12 articles (01/2022 - 02/2007)
9.	Wang, Wei: 12 articles (01/2022 - 08/2009)
10.	Miettinen, Tatu A: 12 articles (08/2011 - 03/2003)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "Nanoparticles with ester links, which hydrolyze more readily, yield a stronger immune response with 75% of tumors eliminated when combined with aPD-1. " 02/01/2005 - "Both in vitro and in vivo anti-tumor activity studies for these esters were conducted and the data demonstrated positive results, that is, these esters were active against the tested tumor lines. " 11/28/2023 - "Ester et al report the findings from a 2-arm cluster randomized controlled trial nested within a hybrid effectiveness-implementation study, which involved a 12-week exercise and behavior change program for rural and remote Canadians (Exercise for Cancer to Enhance Living Well [EXCEL]). " 02/01/2022 - "This study shows the potential anticancer properties of CAPE and highlights how a phenethyl ester component addition can improve the pharmacological potency in relation to its precursor CA. Our results showed that CAPE was more efficient and selective in reducing the viability of tumor cells compared to the control osteoblasts (MC3T3-E1) (p < 0.05). " 01/01/2022 - "The results of this study have sufficient credence to support that the synthesised ester (SAPE) be considered as an anti-oxidative and anti-inflammatory compound with therapeutic potential for the effective management of cancer."
2.	Inflammation (Inflammations) 12/01/2015 - "The study revealed that TMGA esters exerted hepatoprotective effects in CCl4-induced rats, specifically by modulating oxidative-nitrosative stress and inflammation." 09/01/2023 - "The histopathological analysis showed a marked increase in inflammation followed by hepatocytes ballooning in BSO-induced group and steatosis control group, which was ameliorated by GSH ester administration. " 01/01/2023 - "The structure-activity relationship exposed the importance of lipophilic substituents especially ester and n-propyl group for inhibition of inflammation. " 12/01/2021 - "The anti-inflammation pathways might be the key mechanism of JL for the treatment of PDM based on KEGG pathway enrichment analysis and pharmacological experiment, and 10-hydroxyoleoside dimethyl ester might be a promising leading compound due to its good molecular docking scores and previous experimental evaluation." 09/01/2021 - "Fluroxypyr-1-methylheptyl ester interferes with the normal embryogenesis of zebrafish by inducing apoptosis, inflammation, and neurovascular toxicity."
3.	Breast Neoplasms (Breast Cancer) 02/01/2005 - "Ester 3 was active against human breast carcinoma in mice and the toxicity of the agent was not observed in mice during the treatment, implying that this agent is effective for treatment with low toxicity." 01/01/2022 - "In this study, we used the QSAR and extreme learning machine models in predicting the bioactivities of some 2-alkoxycarbonylallyl esters as potential drug candidates against MDA-MB-231 breast cancer. " 01/01/2022 - "Predicting the Anticancer Activity of 2-alkoxycarbonylallyl Esters against MDA-MB-231 Breast Cancer - QSAR, Machine Learning and Molecular Docking." 12/14/2020 - "Due to insufficient water solubility of the di-ester, only the mono-ester complex has been tested regarding its antiproliferative activity against HeLa- (cervix) and MCF-7- (breast) cancer cell lines and a healthy fibroblast cell line (V79). " 08/19/2020 - "Ester 6 was shown to significantly inhibit the proliferation of MCF-7 breast cancer cells by inducing G1 phase arrest. "
4.	Leukemia 06/15/2019 - "The new compounds were designed based on the structures of our previous arylamine ester derivatives endowed with high P-gp-dependent multidrug resistance reversing activity on a multidrug-resistant leukemia cell line. " 01/01/2018 - "The ester derivatives of the compounds inhibit the growth of the MV4-11 leukemia cell line at submicromolar concentration." 10/01/2017 - "Our results showed that the methyl ester derivative (2) displayed the highest inhibitory activity against human leukemia HL-60 cells. " 11/15/2016 - "Structure-based design of ester compounds to inhibit MLL complex catalytic activity by targeting mixed lineage leukemia 1 (MLL1)-WDR5 interaction." 12/01/2014 - "Taken together our results showed for the first time that daucane esters induces apoptotic cell death through a ROS-mediated mechanism in human leukemia cells. "
5.	Infections 01/01/2021 - "At present, yeasts are used as ideal hosts for producing such esters, due to their availability for high-density fermentation, resistance to phage infection, and tolerance against toxic inhibitors. " 10/10/2017 - "Moreover, esters given intraperitoneally at 50 mg/kg/day to Plasmodium berghei-infected mice showed a very significant (p < 0.01) parasitaemia inhibition (27.8 ± 5.4%) on day 4 post-infection compared to vehicle-treated mice. " 10/01/2016 - "Treatment with synthetic lipophilic tyrosyl ester controls Leishmania major infection by reducing parasite load in BALB/c mice." 09/08/2015 - "For example, Mtb strains that lack long, branched-chain alkyl esters known as dimycocerosates (DIMs) are significantly attenuated in model infections. " 05/05/2014 - "Among emitted VOCs, production of esters and other oxygenated compounds was particularly notable, and these may be attributed to increased oxidative stress resulting from infection. "

Related Drugs and Biologics

1.	Acids
2.	Prodrugs
3.	Phytosterols (Plant Sterols)
4.	Cholesterol
5.	Fatty Acids (Saturated Fatty Acids)
6.	Eicosapentaenoic Acid
7.	Amides
8.	Lipids
9.	Ketones
10.	Esters

Related Therapies and Procedures

1.	Therapeutics
2.	Photochemotherapy (Photodynamic Therapy)
3.	Oral Administration
4.	Ligation
5.	Injections