Erythrosine (Erythrosin)

A tetraiodofluorescein used as a red coloring in some foods (cherries, fish), as a disclosure of DENTAL PLAQUE, and as a stain of some cell types. It has structural similarity to THYROXINE.

Also Known As:

Erythrosin; 2',4',5',7'-Tetraiodofluorescein; Erythrosin B; Erythrosine B; F D & C #3; FDC Red No. 3; FD & C Red No. 3; Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-dihydroxy-2',4',5',7'-tetraiodo-, disodium salt

Networked: 82 relevant articles (1 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Beharry, Andrew A: 2 articles (07/2022 - 01/2022)
2.	Digby, Elyse M: 2 articles (07/2022 - 01/2022)
3.	Kagalwala, Husain N: 2 articles (07/2022 - 01/2022)
4.	Lippert, Alexander R: 2 articles (07/2022 - 01/2022)
5.	Ryan, Lucas S: 2 articles (07/2022 - 01/2022)
6.	Tung, Matthew T: 2 articles (07/2022 - 01/2022)
7.	Aoki, Pedro H B: 2 articles (10/2021 - 10/2020)
8.	Bistaffa, Maria J: 2 articles (10/2021 - 10/2020)
9.	Camacho, Sabrina A: 2 articles (10/2021 - 10/2020)
10.	Toledo, Karina A: 2 articles (10/2021 - 10/2020)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2000 - "The aim of the present work was therefore to study the reproducibility of the histologic grading system by distributing haematoxylin-erythrosin-stained slides from 93 invasive breast cancers to the seven pathology departments within the southern healthcare region of Sweden. " 10/01/2016 - "The features of delayed fluorescence (DF) and phosphorescence in erythrosine stained healthy and cancer-diseased mammary gland tissues of BYRB-line mice were investigated in vitro. " 05/01/1990 - "Chronic erythrosine ingestion may promote thyroid tumor formation in rats via chronic stimulation of the thyroid by TSH." 07/01/1986 - "The results of the genotoxicity assessment generally exclude FD&C Red No.3 as a genotoxic initiator and suggest that some other mechanism is responsible for the increase in tumors." 01/01/2021 - "The resulting CMS-2 PS displayed selective imaging of mitochondria and exhibited much higher photodynamic therapy efficiency toward cancer cells than that of the commercial PS erythrosine B. "
2.	Hyperplasia 07/01/1986 - "Data from the CCMA chronic studies revealed an increased incidence of thyroid follicular cell hyperplasia and adenomas in male rats that received 4% FD&C Red No.3 in the diet (2464 mg/kg/day) during life-time (30 months) following in utero exposure. " 10/01/1987 - "In male rats receiving 4.0% FD & C Red No. 3 (2464 mg/kg/day) thyroid weights were increased, with a mean weight of 92 mg compared to 44 mg for controls, and statistically significant increases in the incidence of thyroid follicular cell hypertrophy, hyperplasia and adenomas were recorded. " 01/01/1997 - "Inhibition of this enzyme by FD&C Red No. 3 lowers circulating T3 levels, which results in a compensatory increased secretion of thyroid-stimulating hormone (TSH), follicular cell hypertrophy and hyperplasia, and an increased incidence of follicular cell tumors in 2-yr or lifetime studies in rats. " 01/01/1994 - "Inhibition of this enzyme by FD&C Red No. 3, amiodarone, and iopanoic acid lowers circulating T3 levels, which results in a compensatory increased secretion of thyroid-stimulating hormone (TSH), follicular cell hypertrophy and hyperplasia, and an increased incidence of follicular cell tumors in 2-year or lifetime studies in rats. " 12/01/1992 - "Inhibition of this enzyme by FD&C Red No. 3, amiodarone, and iopanoic acid lowers circulating T3 levels which results in a compensatory increased secretion of thyroid stimulating hormone (TSH), follicular cell hypertrophy and hyperplasia, and an increased incidence of follicular cell tumors in 2-year or lifetime studies in rats. "
3.	Hypertrophy 10/01/1987 - "In male rats receiving 4.0% FD & C Red No. 3 (2464 mg/kg/day) thyroid weights were increased, with a mean weight of 92 mg compared to 44 mg for controls, and statistically significant increases in the incidence of thyroid follicular cell hypertrophy, hyperplasia and adenomas were recorded. " 01/01/1997 - "Inhibition of this enzyme by FD&C Red No. 3 lowers circulating T3 levels, which results in a compensatory increased secretion of thyroid-stimulating hormone (TSH), follicular cell hypertrophy and hyperplasia, and an increased incidence of follicular cell tumors in 2-yr or lifetime studies in rats. " 01/01/1994 - "Inhibition of this enzyme by FD&C Red No. 3, amiodarone, and iopanoic acid lowers circulating T3 levels, which results in a compensatory increased secretion of thyroid-stimulating hormone (TSH), follicular cell hypertrophy and hyperplasia, and an increased incidence of follicular cell tumors in 2-year or lifetime studies in rats. " 12/01/1992 - "Inhibition of this enzyme by FD&C Red No. 3, amiodarone, and iopanoic acid lowers circulating T3 levels which results in a compensatory increased secretion of thyroid stimulating hormone (TSH), follicular cell hypertrophy and hyperplasia, and an increased incidence of follicular cell tumors in 2-year or lifetime studies in rats. "
4.	Adenoma (Adenomas) 10/01/1987 - "A numerically increased incidence of thyroid follicular adenomas in female rats given 0.5, 1.0 or 4.0% FD & C Red No. 3 was not statistically significant. " 07/01/1986 - "Data from the CCMA chronic studies revealed an increased incidence of thyroid follicular cell hyperplasia and adenomas in male rats that received 4% FD&C Red No.3 in the diet (2464 mg/kg/day) during life-time (30 months) following in utero exposure. " 01/01/1989 - "FD&C Red No. 3 is a tetraiodinated derivative of fluorescein which in lifetime studies increases the incidence of thyroid follicular cell adenomas in male Sprague-Dawley rats. " 10/01/1987 - "In male rats receiving 4.0% FD & C Red No. 3 (2464 mg/kg/day) thyroid weights were increased, with a mean weight of 92 mg compared to 44 mg for controls, and statistically significant increases in the incidence of thyroid follicular cell hypertrophy, hyperplasia and adenomas were recorded. " 01/01/1975 - "The cytoplasm of the adenoma cells failed to stain with PAS, aniline blue, adehyde fuchsin, aldehyde thionin, orange G or light green, but positively stained granules were found by using erythrosine or carmosine. "
5.	Dental Plaque 05/01/2017 - "Effectiveness of erythrosine-mediated photodynamic antimicrobial chemotherapy on dental plaque aerobic microorganisms: A randomized controlled trial." 10/01/2021 - "To determine the most effective bactericidal incubation and irradiation times of erythrosine-based PDT on in vivo-formed dental plaque biofilms. " 05/01/2017 - "Erythrosine-mediated PACT reduces the extent of dental plaque microbial count and has a potential preventive and therapeutic use in day-to-day life and dental clinics." 07/01/1983 - "Erythrosine and fluorescein inhibited most gram-positive and gram-negative organisms associated with dental plaque, and were bactericidal to selected strains. " 08/01/1977 - "The use of erythrosin and fluorescein for disclosing dental plaque in 81 children aged 11-14 years and in 17 young men is reported. "

Related Drugs and Biologics

1.	Photosensitizing Agents (Photosensitizers)
2.	1-phenyl-3,3-dimethyltriazene (PDT)
3.	Enzymes
4.	Thyrotropin (Thyroid-Stimulating Hormone)
5.	Xanthenes
6.	Rose Bengal
7.	Iopanoic Acid (Telepaque)
8.	Erythrosine (Erythrosin)
9.	Amiodarone (Amiodarona)
10.	Coloring Agents (Dyes)

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Therapeutics
3.	Photochemotherapy (Photodynamic Therapy)
4.	Semiconductor Lasers
5.	Intravenous Injections