Erythema Induratum (Bazin Disease)

A type of panniculitis characterized histologically by the presence of granulomas, vasculitis, and necrosis. It is traditionally considered to be the tuberculous counterpart of nodular vasculitis, but is now known to occur without tuberculous precedent. It is seen most commonly in adolescent and menopausal women, is initiated or exacerbated by cold weather, and typically presents as one or more recurrent erythrocyanotic nodules or plaques on the calves. The nodules may progress to form indurations, ulcerations, and scars.

Also Known As:

Networked: 45 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Lymph Node Tuberculosis (Scrofula)
2.	Vasculitis (Vasculitides)
3.	Pulmonary Tuberculosis
4.	Panniculitis
5.	Hypersensitivity (Allergy)

Experts

1.	De La Torre, Carlos: 1 article (11/2015)
2.	Anibarro, Luis: 1 article (11/2015)
3.	Posada García, Celia: 1 article (11/2015)
4.	Pardavila, Rosa María: 1 article (11/2015)
5.	González-Fernández, Africa: 1 article (11/2015)
6.	Pena, Alberto: 1 article (11/2015)
7.	Ono, Koji: 1 article (08/2015)
8.	Yoshii, Yuta: 1 article (08/2015)
9.	Satoh, Takahiro: 1 article (08/2015)
10.	Oshio, Ayako: 1 article (08/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Erythema Induratum:

1.	Tuberculin (PPD)IBA 11/01/2015 - "Erythema induratum of Bazin induced by tuberculin skin test." 01/01/1953 - "Tuberculin sensitivity in erythema induratum; comparison of the reactions close to and distant from the lesions." 01/01/1924 - "ERYTHEMA INDURATUM: Report of a case treated with tuberculin and the Kromayer Lamp." 01/01/1908 - "Erythema induratum (Bazin) in a Woman aged 21, with Positive Ophthalmo-tuberculin Reaction." 08/01/1949 - "Erythema induratum Bazin; report of a proved case associated with tuberculous lymphadenitis, completely relieved by tuberculin desensitization."
2.	DNA (Deoxyribonucleic Acid)IBA 06/01/2005 - "Recovery of Mycobacterium tuberculosis DNA in biopsies of erythema induratum--results in a series of patients using an improved polymerase chain reaction technique." 08/01/1997 - "Simultaneous occurrence of papulonecrotic tuberculide and erythema induratum and the identification of Mycobacterium tuberculosis DNA by polymerase chain reaction." 12/01/1993 - "Successful treatment of erythema induratum of bazin following rapid detection of mycobacterial DNA by polymerase chain reaction." 09/18/1993 - "Mycobacterium tuberculosis DNA in erythema induratum of Bazin." 01/01/1997 - "Erythema induratum of Bazin as a tuberculid: confirmation of Mycobacterium tuberculosis DNA polymerase chain reaction analysis."
3.	ParaffinIBA 04/01/1997 - "From the 65 patients included in the study, we examined 72 paraffin-embedded skin biopsy specimens with a histologic diagnosis of erythema induratum or nodular vasculitis. " 11/01/2000 - "Only one pair was able to detect the myocobacterial DNA from the paraffin-embedded specimen of the erythema induratum (EI) lesion. "
4.	Isoniazid (Ftivazide)FDA LinkGeneric 01/01/1970 - "Erythema induratum (Bazin) treated with isoniazid." 08/01/2006 - "Erythema induratum affected the lower limb in all patients, with a female predominance, and responded to isoniazid monotherapy, multidrug anti-tuberculosis therapy, or doxycycline. " 04/01/1990 - "We report three cases of patients with erythema induratum of Bazin who showed extreme tuberculin hypersensitivity reactions and a good therapeutic response to isoniazid. " 10/01/1954 - "Streptomycin and isoniazid in treatment of erythema induratum (Bazin's disease)."
5.	InterferonsIBA 08/01/2011 - "Usefulness of Interferon-γ release assays in the diagnosis of erythema induratum." 10/01/2013 - "Erythema induratum: case series illustrating the utility of the interferon-γ release assay in determining the association with tuberculosis." 12/01/2013 - "Hidden tuberculous lymphadenitis and miliary tuberculosis in an erythema induratum patient: usefulness of interferon-γ release assays in the diagnosis."
6.	Streptomycin (Streptomycin Sulfate)FDA Link 07/01/1951 - "Streptomycin therapy of erythema induratum." 10/01/1954 - "Streptomycin and isoniazid in treatment of erythema induratum (Bazin's disease)."
7.	LipodermatosclerosisIBA 09/01/2001 - "This paper examines newer concepts in five types of panniculitis: i.e., histiocytic cytophagic panniculitis, erythema induratum, lipodermatosclerosis, pancreatic panniculitis and alpha-1-antitrypsin deficiency panniculitis. " 01/01/2002 - "Thirty of 341 cases of different types of panniculitides were found to show pseudomembranous fat necrosis, namely: 10 of 15 cases of sclerosing panniculitis (lipodermatosclerosis), 6 of 95 cases of erythema nodosum, 7 of 34 cases of traumatic panniculitis, 1 of 7 cases of lupus panniculitis, 1 of 20 cases of erythema induratum Bazin (nodular vasculitis), 1 of 9 cases of necrobiosis lipoidica, 1 of 4 cases of sclerotic lipogranuloma, 1 of 9 cases of infectious panniculitis (erysipelas), 1 of 2 cases of pancreatic panniculitis, and 1 of 4 cases of subcutaneous sarcoidosis. "
8.	SteroidsIBA 03/01/1988 - "This case report emphasizes the importance of an exhaustive search for active tuberculosis in patients with erythema induratum, especially in countries where tuberculosis is prevalent, as the indiscriminate treatment of erythema induratum with steroids may be harmful."
9.	OxygenIBA 05/01/1970 - "[Changes in oxygen pressure in hypodermis in Bazin's erythema induratum during oxygen inhalation]."
10.	Methenamine (Hexamine)IBA 02/01/1980 - "The first patient had granulomatous leg lesions that microscopically showed characteristics of erythema induratum but with budding yeastlike organisms demonstrated by Grocott methenamine silver stain. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 02/01/2000 - "Finally, erythema induratum was diagnosed and she was successfully treated with antituberculous chemotherapy. " 09/11/1996 - "[Tb-chemotherapy is efficient in erythema induratum. " 07/01/2011 - "Recurrence of erythema induratum of Bazin in a patient under chemotherapy for breast cancer."
2.	Skin Transplantation (Skin Grafting) 01/01/1953 - "Erythema induratum treated with skin grafting; report of a case."
3.	Ganglionectomy 04/01/1936 - "Bazin's Disease Associated with Raynaud's Disease, treated by Lumbar Ganglionectomy."