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Ergotism (St. Anthony's Fire)

Poisoning caused by ingesting ergotized grain or by the misdirected or excessive use of ergot as a medicine.

Also Known As:

St. Anthony's Fire; Saint Anthony's Fire; Poisoning, Ergot; Ergot Poisonings; Ergotisms; Fire, St. Anthonys; Poisonings, Ergot; Saint Anthony Fire; St. Anthony Fire; Ergot Poisoning; Saint Anthonys Fire; St. Anthonys Fire

Networked: 160 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Substance-Related Disorders: 9381
- Poisoning: 26707

Related Diseases

1.	Fibrosis (Cirrhosis)
2.	Migraine Disorders (Migraine)
3.	Ischemia
4.	Ergotism (St. Anthony's Fire)
5.	Mycotoxicosis (Fungus Poisoning)

Experts

1.	Slawek, Jaroslaw: 1 article (09/2015)
2.	Garcia-Ruiz, Pedro J: 1 article (09/2015)
3.	Sitek, Emilia J: 1 article (09/2015)
4.	Martinez Castrillo, Juan Carlos: 1 article (09/2015)
5.	Thomas, Florian P: 1 article (05/2015)
6.	Gondim, Francisco De Assis Aquino: 1 article (05/2015)
7.	Griesbach, Sarah H: 1 article (05/2015)
8.	Bednarski, Marek: 1 article (04/2015)
9.	Nowak, Gabriel: 1 article (04/2015)
10.	Sapa, Jacek: 1 article (04/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ergotism:

1.	Ergotamine (Ergotamine Tartrate)FDA LinkGeneric 01/01/1982 - "In both these models of ergotism, the directly acting vasodilator nitroglycerine (NTG) effectively relieved the ergotamine-induced arterial contractions. " 08/01/2014 - "In this series, most cases of severe ergotism were associated with interaction with CYP3A4 inhibitors, which increase ergotamine bioavailability. " 07/30/2014 - "Another vasoconstrictive syndrome, "ergotism," is caused by a parasitic fungus, Claviceps purpurea, and its primary toxin, ergotamine. " 06/01/2014 - "Most patients take ergotamine improperly, apart from the fact that potential interactions may increase the risk of health problems such as ergotism and coronary events. " 01/01/2012 - "Some drugs have the capacity of interacting with small amounts of ergotamine or its derivatives producing ergotism as a side effect. "
2.	NicergolineIBA 04/01/2015 - "Additionally, nicergoline exhibits a safety profile comparable to that of placebo, and none of the reviewed studies reported any incidence of fibrosis or ergotism with nicergoline treatment. " 01/01/2014 - "None of the studies included in this systematic review reported any incidence of fibrosis or ergotism with nicergoline." 01/01/2014 - "None of the studies reported any incidence of fibrosis or ergotism with nicergoline treatment. "
3.	Nitroprusside (Sodium Nitroprusside)FDA LinkGeneric 02/01/2008 - "Ergotism unresponsive to multiple therapeutic modalities, including sodium nitroprusside, resulting in limb loss." 08/01/1989 - "In situations of threatened limb or organ loss, sodium nitroprusside appears to rapidly reverse the vasospasm due to ergotism and is likely the therapy of choice." 01/01/1986 - "Intraarterial sodium nitroprusside infusion in the treatment of severe ergotism." 10/10/1981 - "[Sodium nitroprusside in ischaemic complications of acute ergot poisoning (author's transl)]." 07/01/1978 - "Nitroprusside in ergot poisoning."
4.	Ergot AlkaloidsIBA 03/01/2014 - "Due to the alarming historical experience with severe toxicity and the syndrome of ergotism from natural and synthetic ergot alkaloids, triage recommendations for pediatric exposures to medicinal agents containing ergot alkaloids may be inappropriate and inconsistent. " 01/01/2014 - "Ergotism (generally associated with grasses, rye, triticale and other grains) and fescue toxicosis (associated with tall fescue grass, Festuca arundinacea) are both caused by ergot alkaloids, and referred to as 'ergot alkaloid intoxication'. " 03/01/2013 - "Ergotism is a horrendous disease with grotesque symptoms caused by ingesting specific ergot alkaloids. " 05/01/2011 - "After a brief history of ergot alkaloids and ergotism, this review focuses on the metabolism and mechanisms of action of the ergot alkaloids. " 09/01/2004 - "Ergotism should be considered in patients treated by ergot alkaloids presenting an atypical clinical manifestations."
5.	heparin-dihydergot FDA Link 01/24/1987 - "Ergotism as complication of thromboembolic prophylaxis with heparin-dihydroergotamine." 01/01/1987 - "Severe vasospastic reactions (ergotism) during prophylactic administration of heparin-dihydroergotamine." 03/11/1983 - "[Ergotism in heparin-dihydroergotamine therapy]." 02/01/1983 - "The authors present two cases of ergotism in polytraumatised patients after prophylactic treatment with the combination preparation heparin-dihydroergotamine. " 07/10/1982 - "Ergotism and heparin-dihydroergotamine [letter]."
6.	Ritonavir (Norvir)FDA Link 01/01/2012 - "Ergotism induced by ritonavir?]." 01/01/2001 - "Clinical ergotism induced by ritonavir." 11/01/1999 - "Ischaemic peripheral neuritis secondary to ergotism associated with ritonavir therapy." 01/01/2012 - "Here we present a case of ergotism that developed in an HIV positive 39 year old male under treatment with ritonavir, after taking 1 mg of ergotamine tartrate. " 12/01/2011 - "Ergotism secondary to ergotamine-ritonavir association was diagnosed. "
7.	Dihydroergotamine (Agit)FDA LinkGeneric 07/01/2003 - "Dihydroergotamine binds to serotonin receptors in the dorsal horn of the spinal cord, which is the site of neuropathological changes in convulsive ergotism. " 08/01/1988 - "Dihydroergotamine-erythromycin-induced ergotism." 09/13/1986 - "Ergotism as complication of thromboembolic prophylaxis with heparin and dihydroergotamine." 09/26/1981 - "[Acute ergotism caused by the interaction of erythromycin propionate and dihydroergotamine]." 03/01/1980 - "[Ergotism in a psychiatric setting caused by combined dihydroergotamine-erythromycin propionate. "
8.	Erythromycin (Erycette)FDA LinkGeneric 01/01/2000 - "Ergotism precipitated by erythromycin: a rare case of vasospasm." 10/01/2000 - "Clinical ergotism with severe bilateral upper limb ischaemia precipitated by an erythromycin--ergotamine drug interaction." 08/01/1988 - "Dihydroergotamine-erythromycin-induced ergotism." 06/01/1984 - "We report a case of ergotism due to the interaction of erythromycin with a small dose of ergotamine tartrate (2 mg). " 01/01/2001 - "When ergopeptide metabolism is inhibited by the presence of macrolide antibacterials, particularly troleandomycin and erythromycin, the resultant interaction can produce ergotism, sometimes leading to gangrene. "
9.	Troleandomycin (TAO)FDA Link 01/01/1969 - "Precipitation of acute ergotism by triacetyloleandomycin." 06/27/1979 - "Two cases of acute ergotism are described in patients taking therapeutic oral doses of ergotamine tartrate and concomitant triacetyloleandomycin. " 01/21/1978 - "[Acute ergotism caused by dihydroergotamine-triacetyloleandomycin association]." 01/01/2001 - "When ergopeptide metabolism is inhibited by the presence of macrolide antibacterials, particularly troleandomycin and erythromycin, the resultant interaction can produce ergotism, sometimes leading to gangrene. " 01/01/1978 - "[From colitis to acute ergotism; or illustration of the risk of the triacetyloleandomycin-ergotamine tartrate combination in digestive pathology]."
10.	MycotoxinsIBA 12/01/2009 - "Mycotoxins are compounds of fungal origin that can adversely affect human, animal and plant health through food spoilage or infection, even to the point of epidemics such as turkey X disease and ergotism. " 10/01/1983 - "The ubiquitous and insidious mycotoxins have been more or less causally linked to several human diseases, from ergotism to Reye's syndrome, as well as enormous livestock morbidity and mortality. " 11/01/2013 - "The main mycotoxicoses observed in grazing cattle include intoxications by indole-diterpenoid mycotoxins (Paspalum spp. contaminated by Claviceps paspali, Lolium perenne infected by Neotyphodium lolii, Cynodon dactylon infected by Claviceps cynodontis, and Poa huecu), gangrenous ergotism and dysthermic syndrome (hyperthermia) caused by Festuca arundinacea (syn. " 12/01/1995 - "The discovery of aflatoxins in the early 1960s led to the resurgence of interest in human mycotoxicoses; mycotoxins are now recognized as causal factors of primary liver cancer, ergotism and alimentary toxic aleukia. " 01/01/1993 - "The putative involvement of mycotoxins in human diseases, including cancer, is reviewed with reference to ergotism, citreoviridin toxicosis, alimentary toxic aleukia, stachybotryotoxicosis, Balkan endemic nephropathy and aflatoxicoses. "

Therapies and Procedures

1.	Amputation 09/15/2015 - "This unique combination of dystonia and limb amputation probably represents ergotism. " 06/01/2006 - "We suggest that in the latter case ergotism can explain both manifestations: peripheral vascular disease leading to amputation, and cervical dystonia.Finally" 06/01/1985 - "Ergotism with severe arterial circulatory disorders, sometimes leading to amputation of the leg, is a severe complication following application of drugs containing ergotamine. " 04/24/1982 - "Ergotism leading to threatened limb amputation or to death in two patients given heparin-dihydroergotamine prophylaxis."
2.	Witchcraft (Sorceries) 01/01/2000 - "Recently, ergot poisoning has been put forth by some as a previously unsuspected cause of the bizarre behaviors of the young adolescent girls who accused the townsfolk of witchcraft. " 10/01/1983 - "The controversial hypothesis that the Salem witchcraft panic of 1692 resulted from ergot poisoning was recently defended by Mary Matossian. "
3.	Angioplasty (Angioplasty, Transluminal) 01/01/1987 - "Ergotism presenting as restenosis following angioplasty." 01/01/1987 - "Ergotism may cause isolated lower-extremity arterial stenoses that appear amenable to angioplasty but that will recur if the causative agent is not withdrawn. " 08/01/2008 - "The authors report a rare case of ergotism related to lysergic acid diethylamide (LSD) ingestion and describe unconventional treatment of associated extensive lower extremity vasospasm with use of balloon percutaneous transluminal angioplasty."
4.	Intra-Arterial Infusions 05/01/1985 - "[Intra-arterial infusion of SNP for peripheral ischemia caused by acute ergotism]." 01/01/1986 - "We think that intraarterial infusion of sodium nitroprusside, associated with forced diuresis and the administration of hydroxycobalamin, constitutes the treatment of choice of extreme peripheral ischemia of ergotism."
5.	Drug Therapy (Chemotherapy) 09/01/2007 - "After establishing the diagnosis of chronic gangrenous ergotism, changing drug therapy, mobilization, and treatment of chronic wounds, she showed a remarkable recovery. " 12/11/1981 - "[Ergotism--an important complication of drug therapy in prevention of thromboembolism]."