Ergot Alkaloids

Alkaloids originally isolated from the ergot fungus Claviceps purpurea (Hypocreaceae). They include compounds that are structurally related to ergoline (ERGOLINES) and ergotamine (ERGOTAMINES). Many of the ergot alkaloids act as alpha-adrenergic antagonists.

Also Known As:

Networked: 156 relevant articles (10 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Diener, H C: 5 articles (12/2004 - 01/2001)
2.	Katsarava, Z: 4 articles (12/2004 - 01/2001)
3.	Limmroth, V: 3 articles (12/2004 - 01/2001)
4.	Galuszka, Petr: 2 articles (12/2015 - 01/2013)
5.	Frébort, Ivo: 2 articles (12/2015 - 01/2013)
6.	Uhlig, Silvio: 2 articles (12/2009 - 01/2007)
7.	Wan, Stephanie R: 2 articles (06/2006 - 06/2006)
8.	Briggs, Gerald G: 2 articles (06/2006 - 06/2006)
9.	Guédon-Moreau, Laurence: 2 articles (02/2004 - 11/2003)
10.	Duc, Marie-Francoise: 2 articles (02/2004 - 11/2003)

Related Diseases

1.	Migraine Disorders (Migraine) 10/01/2009 - "Ergot alkaloids and their derivatives have been traditionally used as therapeutic agents in migraine, blood pressure regulation and help in childbirth and abortion. " 11/01/2003 - "Ergot alkaloids have been the mainstay of acute migraine therapy for most of the 20th century. " 11/01/2001 - "Ergot alkaloids are commonly used for migraine headaches and have vasoconstrictive properties. " 06/01/2001 - "These pharmacological characteristics of SMT were different from those of ergot alkaloids, current anti-migraine drugs, which contracted coronary, femoral and other arteries as well. " 01/01/1994 - "[Therapy of migraine with special reference to ergot alkaloids]."
2.	Vomiting 02/11/1982 - "It is very effective against emesis induced by apomorphine and dihydrogenated ergot alkaloids in dogs. " 01/01/2007 - "Ergot alkaloids increased the risk of vomiting (RR 11.81, 95% CI 1.78 to 78.28), elevation of blood pressure (RR 2.60, 95% CI 1.03 to 6.57) and pain after birth requiring analgesia (RR 2.53, 95% CI 1.34 to 4.78). " 01/01/2007 - "Prophylactic intramuscular or intravenous injections of ergot alkaloids are effective in reducing blood loss and postpartum haemorrhage, but adverse effects include vomiting, elevation of blood pressure and pain after birth requiring analgesia, particularly with the intravenous route of administration." 01/01/2013 - "Use of prophylactic oxytocin was associated with fewer side effects compared with use of ergot alkaloids; including decreased nausea between delivery of the baby and discharge from the labour ward (RR 0.18; 95% CI 0.06 to 0.53; three trials, 1091 women; T² = 0.41, I² = 41%) and vomiting between delivery of the baby and discharge from the labour ward (RR 0.07; 95% CI 0.02 to 0.25; three trials, 1091 women; T² = 0.45, I² = 30%). "
3.	Pain (Aches) 01/01/2007 - "Ergot alkaloids increased the risk of vomiting (RR 11.81, 95% CI 1.78 to 78.28), elevation of blood pressure (RR 2.60, 95% CI 1.03 to 6.57) and pain after birth requiring analgesia (RR 2.53, 95% CI 1.34 to 4.78). " 01/01/2007 - "Prophylactic intramuscular or intravenous injections of ergot alkaloids are effective in reducing blood loss and postpartum haemorrhage, but adverse effects include vomiting, elevation of blood pressure and pain after birth requiring analgesia, particularly with the intravenous route of administration." 01/01/1993 - "Accordingly, this chapter will review the consequences of trigeminovascular activation to pain and meningeal inflammation, and will summarize emerging molecular and pharmacological data suggesting that ergot alkaloids and sumatriptan alleviate pain primarily via activation of pre-junctional 5-HT1 heteroreceptors residing on primary afferent trigeminovascular fibers." 01/01/1991 - "The antimigraine effects of ergot alkaloids, sumatriptan and NSAIDs are discussed in the light of the common vasoconstrictor actions of these agents and knowledge that vasodilatation is apparently not responsible for migraine headache pain in most cases." 09/01/1989 - "Pharmacologic intervention with nontraditional analgesics such as antidepressants, anticonvulsants, and ergot alkaloids, is often useful in the management of chronic pain disorders, including those in the orofacial region. "
4.	Cerebrovascular Disorders (Cerebrovascular Occlusion) 03/20/1970 - "Dihydrogenated ergot alkaloids (Hydergine) and cerebrovascular insufficiency." 01/01/1985 - "Seventy-six patients took part in a randomized, comparative study of the efficacy of buflomedil hydrochloride and dihydrogenated ergot alkaloids in the treatment of senile dementia associated with cerebrovascular insufficiency. " 01/01/1985 - "In conclusion, buflomedil is as effective or more effective than dihydrogenated ergot alkaloids in the treatment of senile dementia associated with cerebrovascular insufficiency and could prove a valuable addition to long-term therapy if further studies support the trend shown in this study." 01/01/1985 - "The treatment of senile dementia associated with cerebrovascular insufficiency: a comparative study of buflomedil and dihydrogenated ergot alkaloids."
5.	Alzheimer Disease (Alzheimer's Disease) 01/01/1985 - "Seventy-six patients took part in a randomized, comparative study of the efficacy of buflomedil hydrochloride and dihydrogenated ergot alkaloids in the treatment of senile dementia associated with cerebrovascular insufficiency. " 01/01/1985 - "In conclusion, buflomedil is as effective or more effective than dihydrogenated ergot alkaloids in the treatment of senile dementia associated with cerebrovascular insufficiency and could prove a valuable addition to long-term therapy if further studies support the trend shown in this study." 01/01/1985 - "The treatment of senile dementia associated with cerebrovascular insufficiency: a comparative study of buflomedil and dihydrogenated ergot alkaloids."

Related Drugs and Biologics

1.	Sumatriptan (Imigran)
2.	Apomorphine
3.	buflomedil (Lofton)
4.	Analgesics (Analgesic Drugs)
5.	Anticonvulsants (Antiepileptic Drugs)
6.	Antidepressive Agents (Antidepressants)
7.	Piribedil (Trivastal)
8.	DEAE-Dextran (Pulsar)
9.	bosentan (Tracleer)
10.	Tryptamines (Triptans)

Related Therapies and Procedures

1.	Intravenous Injections
2.	Analgesia
3.	Drug Therapy (Chemotherapy)
4.	Vagotomy
5.	Self Medication