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Ergonovine (Ergometrine)

An ergot alkaloid (ERGOT ALKALOIDS) with uterine and VASCULAR SMOOTH MUSCLE contractile properties.

Also Known As:

Ergometrine; Bedford Brand of Ergonovine Maleate; Ergobasin; Ergometrin; Ergometrine Maleate; Ergotrate; Ergonovine Maleate; Ergoline-8-carboxamide, 9,10-didehydro-N-(2-hydroxy-1-methylethyl)-6-methyl-, (8beta(S))-

Networked: 688 relevant articles (37 outcomes, 69 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- Alkaloids: 1065
  - Ergot Alkaloids: 156
    - Ergolines: 88
      - Ergonovine: 688
        Methylergonovine: 145
        syntometrine: 23
        ergonovine tartrate
- Heterocyclic Compounds with 4 or More Rings
  - Ergolines: 88
    - Ergonovine: 688

Experts

1.	Kohno, Hiroaki: 7 articles (09/2015 - 09/2003)
2.	Sueda, Shozo: 7 articles (09/2015 - 09/2003)
3.	Uraoka, Tadao: 6 articles (07/2015 - 09/2003)
4.	Fukuda, Hiroshi: 5 articles (05/2010 - 09/2003)
5.	Cherng, Wen-Jin: 5 articles (05/2008 - 08/2002)
6.	Hung, Ming-Jui: 5 articles (05/2008 - 08/2002)
7.	Jeong, Myung Ho: 4 articles (11/2010 - 06/2006)
8.	Adachi, Yoshihiko: 4 articles (11/2004 - 11/2002)
9.	Ito, Kazuki: 4 articles (11/2004 - 11/2002)
10.	Azuma, Akihiro: 4 articles (11/2004 - 11/2002)

Related Diseases

1.	Spasm (Spasms) 04/01/1997 - "After 3 months of medication, left ventriculography disclosed a marked improvement, and coronary spasm was evoked in the proximal portion of left anterior descending artery after intracoronary ergonovine provocations. " 06/01/2004 - "Coronary stenting of the site identified by ergonovine provocation testing was effective in relieving provoked and spontaneous spasm." 12/01/1986 - "Prior infusion of CGRP did not prevent coronary arterial spasm induced by ergonovine in two patients with variant angina, but a subsequent bolus of CGRP partially relieved the spasm. " 12/01/1981 - "Remission of coronary spasm confirmed by angiography and ergometrine provocation: two case reports." 10/01/1981 - "We analyzed the results of 61 consecutive outpatient ergonovine provocation tests to determine the safety and efficacy of such outpatient testing for detecting coronary artery spasm (CAS). "
2.	Postpartum Hemorrhage 07/01/1997 - "A placebo-controlled trial of oral ergometrine to reduce postpartum hemorrhage." 05/01/1996 - "A placebo-controlled trial of oral ergometrine to reduce postpartum hemorrhage." 01/01/1999 - "Fourteen women with established postpartum hemorrhage not responding to oxytocine and ergometrine regimens, or not responsive to oxytocine and having contraindications to ergometrine. " 05/01/1996 - "Active management with oral ergometrine 0.4 mg was compared with expectant management for the control of blood loss in the third stage of labor in women at low risk of postpartum hemorrhage (PPH). " 09/01/1965 - "Prevention of postpartum hemorrhage with ergonovine: an analysis of 19,510 cases."
3.	Chest Pain (Chest Pains) 12/01/1984 - "Out of 708 patients with angiographically normal or near-normal coronary arteries undergoing the ergometrine test for assessment of chest pain, 78 patients with positive results were retained for study. " 12/15/1998 - "Chest pain of undetermined etiology was the final diagnosis at discharge in 10 patients (5%, 10 of 208); among them chest pain redeveloped in 2 patients, and repeated ergonovine echocardiography revealed positive results. " 03/01/2013 - "The patient described in this study initially presented with atypical chest pain and underwent coronary angiography and ergonovine provocation tests, which were negative. " 10/01/1995 - "The aim of this study was to assess the feasibility and diagnostic role of ergonovine maleate infusion under continuous two-dimensional echocardiographic monitoring for the identification of vasospastic myocardial ischaemia in patients with chest pain at rest not associated with diagnostic ECG changes. " 01/01/1986 - "We report the vasoactive effects of ergonovine maleate in 66 patients with chest pain and abnormal angiographic studies. "
4.	Pathologic Constriction (Stenosis) 01/01/1983 - "By contrast, with a stenosis greater than 28.4 +/- 5.0 mmHg in pressure gradient, created by intraluminal obstruction which preserved active arterial vasomotion, ergonovine-induced vasoconstriction produced a marked decrease in coronary blood flow and distal coronary pressure, followed by ST-elevation. " 01/01/2005 - "Previous studies have shown that ergonovine stress echocardiography (ESE) may be a valuable noninvasive tool for the diagnosis of vasospasm after the confirmation of no significant fixed stenosis. " 05/01/2006 - "Of 121 patients with clinically suspected angina without fixed stenosis in the coronary arteries, vasospasm was provoked in 82 patients with 92 lesions (42 focal, 50 diffuse) by intravenous ergonovine maleate injection. " 11/01/2002 - "Prognostic implication of ergonovine echocardiography in patients with near normal coronary angiogram or negative stress test for significant fixed stenosis." 11/01/2000 - "Stenting of a mild stenosis in that artery successfully controlled vasospasm and a pre-discharge ergonovine echocardiographic test was negative. "
5.	Myocardial Ischemia (Ischemic Heart Diseases) 09/01/1991 - "A study of 68 patients showed that the ergometrine test is a rather informative method of the diagnosis of ischemic heart disease that supplements essentially the results of loading tests. " 04/01/2006 - "Eighty-two patients with VA, confirmed by coronary angiography with or without ergonovine provocation test, and 114 apparently healthy control subjects were investigated for genotype of 4 AR polymorphisms and established risk factors of ischemic heart disease. " 06/01/2000 - "Ergonovine echocardiography was terminated prematurely in 13 patients (0.9%) because of limitations caused by side effects unrelated to myocardial ischemia. " 09/01/1994 - "To investigate which time constant of isovolumic left ventricular pressure (LVP) decay is the most sensitive measure in acute myocardial ischemia, the time constant of isovolumic relaxation (IR) was calculated by two different models, the semilogarithmic model assuming a zero of LVP decline (TL) and an exponential model (Texp) with an asymptote (extrapolated baseline pressure to which LVP would fall if decay continued indefinitely), in 10 patients before and during ergonovine-induced vasospastic angina. " 09/01/1991 - "[The significance of the ergometrine test for the diagnosis of ischemic heart disease and the choice of antianginal treatment]."

Related Drugs and Biologics

1.	Oxytocin (Pitocin)
2.	Misoprostol (Cytotec)
3.	Nifedipine (Adalat)
4.	Acetylcholine (Acetylcholine Chloride)
5.	syntometrine
6.	Nicorandil (SG 75)
7.	Isosorbide Dinitrate (Isordil)
8.	Prostaglandins
9.	Nitroglycerin (Dynamite)
10.	isosorbide-5-mononitrate (Ismo)

Related Therapies and Procedures

1.	Angioplasty (Angioplasty, Transluminal)
2.	Intravenous Injections
3.	Cesarean Section (Caesarean Section)
4.	Intravenous Infusions
5.	Coronary Balloon Angioplasty (Percutaneous Transluminal Coronary Angioplasty)