Equilin

01/01/2019 - "Despite evidence describing protective effects against risk factors for cardiovascular diseases by naturally occurring estrogens, little is known about the vascular effects of equilin, one of the main components of CEE and not physiologically present in women. "

09/01/2003 - "equilin (Eq) and 17alpha-dihydroequilin (Dheq) on the proliferation of human breast cancer cells. "
10/01/2019 - "PGRMC1 can trigger estrogen-dependent proliferation of breast cancer cells: estradiol vs. equilin vs. ethinylestradiol."
02/01/1999 - "Finally, preliminary studies conducted with the human breast tumor cell line MCF-7 demonstrated that the cytotoxic effects of the catechol estrogens from estrone, equilin, and 2-hydroxyequilenin were similar, whereas 4-hydroxyequilenin was a much more potent cytotoxin ( approximately 30-fold). "

01/01/2019 - "Further studies comparing equilin treatment with that of E2 are needed to investigate their differential impacts on atherosclerosis."

01/01/2019 - "In this regard, the present study aims to compare the vascular effects of equilin in an experimental model of hypertension with those induced by 17β-estradiol. "

04/01/2010 - "For 2.5mg equilin, palpable tumors were observed in 8.3% of the rats after 8 weeks' treatment; the frequency was lower than that (42.9%) observed with 2.5mg E(2). "
04/01/2010 - "ACI rats given 10mg equilin developed palpable mammary tumors at 13 weeks of treatment, and 37.5% of the rats developed mammary tumors within 15 weeks. "
04/01/2010 - "A pellet containing equilin was inserted under the skin of female ACI rats and the development of mammary tumors was monitored. "
04/01/2010 - "Evidently, equilin is a mammary carcinogen, and this potential may be associated with development of breast and reproductive cancers in women receiving hormone replacement therapy."
11/01/1983 - "When equilin and d-equilenin, components of therapeutic conjugated estrogens, were tested, only equilin had a 76% incidence of renal tumor foci (5.5 +/- 0.9). "