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Epoxide Hydrolases

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Enzymes that catalyze reversibly the formation of an epoxide or arene oxide from a glycol or aromatic diol, respectively.

Also Known As:

9,10-Epoxypalmitic Acid Hydrase; Microsomal Epoxide Hydrolase; Styrene Epoxide Hydrolase; 9,10 Epoxypalmitic Acid Hydrase; Acid Hydrase, 9,10-Epoxypalmitic; Epoxide Hydrolase, Microsomal; Epoxide Hydrolase, Styrene; Hydrase, 9,10-Epoxypalmitic Acid; Hydrases, Epoxide; Hydratases, Epoxide; Hydrolase, Microsomal Epoxide; Hydrolase, Styrene Epoxide; Hydrolases, Epoxide; Epoxide Hydrases; Epoxide Hydratases; Epoxide hydrolase

Networked: 509 relevant articles (15 outcomes, 58 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hammock, Bruce D: 107 articles (12/2015 - 02/2002)
2.	Morisseau, Christophe: 54 articles (12/2015 - 02/2002)
3.	Hwang, Sung Hee: 22 articles (12/2015 - 01/2009)
4.	Imig, John D: 22 articles (01/2015 - 02/2002)
5.	Yang, Jun: 20 articles (12/2015 - 01/2009)
6.	Kim, In-Hae: 14 articles (12/2015 - 04/2004)
7.	Tsai, Hsing-Ju: 14 articles (12/2015 - 05/2005)
8.	Inceoglu, Bora: 14 articles (12/2015 - 11/2006)
9.	Alkayed, Nabil J: 14 articles (09/2015 - 12/2007)
10.	Liu, Jun-Yan: 13 articles (12/2015 - 01/2009)

Related Diseases

1.	Stroke (Strokes) 09/01/2015 - "Peroxisomal translocation of soluble epoxide hydrolase protects against ischemic stroke injury." 01/01/2014 - "Mechanism of protection by soluble epoxide hydrolase inhibition in type 2 diabetic stroke." 05/01/2008 - "Genetic variation in soluble epoxide hydrolase (EPHX2) is associated with an increased risk of ischemic stroke in white Europeans." 12/01/2007 - "Soluble epoxide hydrolase: a novel therapeutic target in stroke." 10/01/2005 - "We investigated the association of polymorphisms in the soluble epoxide hydrolase gene (EPHX2) with incident ischemic stroke in African-Americans and Whites. "
2.	Pain (Aches) 01/30/2013 - "Comparative efficacy of 3 soluble epoxide hydrolase inhibitors in rat neuropathic and inflammatory pain models." 07/21/2015 - "A recently identified, nonchannel, nonneurotransmitter therapeutic target for pain is the enzyme soluble epoxide hydrolase (sEH). " 09/01/2011 - "The soluble epoxide hydrolase as a pharmaceutical target for pain management." 10/14/2010 - "1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain." 05/01/2015 - "Brodie award lecture-epoxide hydrolases: drug metabolism to therapeutics for chronic pain."
3.	Reperfusion Injury 01/01/2012 - "Soluble epoxide hydrolase activity determines the severity of ischemia-reperfusion injury in kidney." 11/01/2008 - "Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo." 01/01/2010 - "Inhibition of soluble epoxide hydrolase by trans-4- [4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is protective against ischemia-reperfusion injury." 04/15/2015 - "Soluble epoxide hydrolase (sEH) has been demonstrated to be a key enzyme involved in the pathologic development of several cardiovascular diseases and inflammation, and inhibition of sEH is therefore very helpful or crucial for the treatment of ischemia-reperfusion injury, cardiac hypertrophy, hypertension and inflammation. "
4.	Pancreatitis 08/01/2015 - "Soluble Epoxide Hydrolase Pharmacological Inhibition Ameliorates Experimental Acute Pancreatitis in Mice." 10/01/2014 - "Soluble epoxide hydrolase deficiency ameliorates acute pancreatitis in mice." 01/01/2014 - "Effects of soluble epoxide hydrolase deficiency on acute pancreatitis in mice."
5.	Lung Neoplasms (Lung Cancer) 05/01/2000 - "Although the three published results for Caucasians are somewhat variable, the association among African-Americans in these data provides some support for the hypothesis that genetically reduced microsomal epoxide hydrolase activity may be protective against lung cancer." 03/01/2015 - "Inconsistent association of microsomal epoxide hydrolase (mEH) polymorphisms (Tyr113His, His139Arg) and lung cancer susceptibility have been reported in earlier studies. " 09/01/2010 - "The aim of this study was to investigate the relationship between EPHXI exon 3 Tyr113His and exon 4 His139Arg polymorphisms, predicted microsomal epoxide hydrolase (mEH) activity, and lung cancer development. " 05/01/2002 - "To investigate the role of microsomal epoxide hydrolase (mEH) polymorphisms in the aetiology of lung cancer and to assess the interaction between mEH polymorphisms and smoking, we performed a meta-analysis of seven published studies, which included 2078 cases and 3081 controls, and a pooled analysis of eight studies (four published and four unpublished at that time) with a total of 986 cases and 1633 controls. " 06/01/2001 - "This study evaluated the influence of genetic polymorphisms in the microsomal epoxide hydrolase (mEPHX) gene on lung cancer risk in a case-control study of two different ethnic groups, Mexican-Americans and African-Americans. "

Related Drugs and Biologics

1.	Acids
2.	Arachidonic Acid (Vitamin F)
3.	Benzoic Acid (Ucephan)
4.	20-hydroxy-5,8,11,14-eicosatetraenoic acid
5.	Streptozocin (Streptozotocin)
6.	SMTP 7
7.	Dinoprostone (PGE2)
8.	Omeprazole (Esomeprazole)
9.	Cytochrome P-450 Enzyme System (Cytochrome P450)
10.	Glutathione Transferase (Glutathione S-Transferase)

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1.	Surgical Instruments (Clip)
2.	Transplants (Transplant)
3.	Cardiopulmonary Resuscitation (CPR)
4.	Therapeutics
5.	Mediterranean Diet