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Epidermal Cyst (Sebaceous Cyst)

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Intradermal or subcutaneous saclike structure, the wall of which is stratified epithelium containing keratohyalin granules.

Also Known As:

Sebaceous Cyst; Sebaceous Cysts; Epidermoid Cyst; Cyst, Epidermal; Cyst, Epidermoid; Cyst, Pilar; Cyst, Sebaceous; Cysts, Epidermal; Cysts, Epidermoid; Cysts, Pilar; Cysts, Sebaceous; Epidermal Cysts; Epidermoid Cysts; Pilar Cysts; Pilar Cyst

Networked: 347 relevant articles (7 outcomes, 12 trials/studies)

Relationship Network

Disease Context: Research Results

Neoplasms: 649836
- Cysts: 16217
  - Epidermal Cyst: 347
    - FLOTCH syndrome: 1

Related Diseases

1.	Cysts
2.	Squamous Cell Carcinoma (Epidermoid Carcinoma)
3.	Basal Cell Carcinoma (Rodent Ulcer)
4.	Pruritus (Itching)
5.	Pilomatrixoma

Experts

1.	van Dijk, Christel E: 2 articles (10/2014 - 01/2011)
2.	de Bakker, Dinny H: 2 articles (10/2014 - 01/2011)
3.	Carlson, J Andrew: 2 articles (08/2011 - 05/2002)
4.	Jakobiec, Frederick A: 2 articles (01/2010 - 09/2009)
5.	Kohmura, Eiji: 2 articles (01/2010 - 05/2005)
6.	Foster, Richard S: 2 articles (07/2003 - 01/2002)
7.	Shet, T: 2 articles (10/2001 - 07/2001)
8.	Rege, J: 2 articles (07/2001 - 03/2001)
9.	Sabhlok, Samrat: 1 article (11/2015)
10.	Kheur, Supriya: 1 article (11/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Epidermal Cyst:

1.	Carcinoembryonic AntigenIBA 06/01/1998 - "Epidermoid cyst of the spleen with CA19-9 or carcinoembryonic antigen productions: report of three cases." 03/01/1994 - "Multiple plantar epidermoid cysts harboring carcinoembryonic antigen and human papillomavirus DNA sequences." 12/01/1989 - "Carcinoembryonic antigen was immunohistochemically demonstrated in the center of the epidermoid cyst and the DAB reaction products took the shape of a circle resembling that of the sweat ducts in the horny layer." 02/01/1987 - "Carcinoembryonic antigen in epidermoid cyst fluid and plasma." 01/01/2010 - "Immunostaining for cytokeratin 17 and carcinoembryonic antigen showed strongly positive results in the Meibomian gland cysts and, by comparison, negative results in cutaneous epidermal cysts. "
2.	Keratin-17 (Keratin 17)IBA 03/01/2003 - "Mutation in the 1A domain of keratin 17 underlies the affected members' phenotype, PC-2 with early onset sebaceous cysts and late-onset thickened fingernails and toenails. " 03/01/2003 - "Keratin 17 mutation in pachyonychia congenita type 2 with early onset sebaceous cysts." 01/01/2010 - "Immunostaining for cytokeratin 17 and carcinoembryonic antigen showed strongly positive results in the Meibomian gland cysts and, by comparison, negative results in cutaneous epidermal cysts. " 06/01/1997 - "We compared the patterns of keratin 10 (K10) and keratin 17 (K17) expression in epidermoid cysts, trichilemmal cysts, eruptive vellus hair cysts, and steatocystoma multiplex. "
3.	imiquimod (Aldara)FDA LinkGeneric 01/01/2007 - "Multiple and clustered eruptive epidermoid cysts following treatment with topical imiquimod." 07/01/2005 - "The multiple comedones and ruptured epidermoid cysts are newly reported adverse effects of imiquimod therapy." 07/01/2005 - "Eruptive epidermoid cysts resulting from treatment with imiquimod." 01/01/2009 - "As reported in the literature and as observed in our clinical experience, the occurrence of epidermoid cysts, after the topical treatment of basal cell carcinomas with imiquimod, may represent a local immune reaction that is drug-related and is a typical remission pattern in particular anatomical areas. " 01/01/2009 - "We report five cases of patients affected by basal cell carcinomas localized in seborrhoeic areas of the face, successfully treated with topical imiquimod and characterized by the occurrence of eruptive epidermoid cysts at the end-point of therapy. "
4.	RetinoidsIBA 03/01/2014 - "We would like to recommend the possibility to administer retinoids in a squamous cell carcinoma, achieving very satisfactory results; in our case, a complete remission of malignant lesion and an improvement of epidermal cysts were made, without the development of side effects associated with retinoids. "
5.	ErbiumIBA 05/01/2015 - "Erbium:yttrium aluminum garnet laser fenestration might be a promising alternative to the surgical treatment of epidermal cysts, especially when the lesions are large or located in an aesthetically important area." 05/01/2015 - "To evaluate the safety and feasibility of erbium:yttrium aluminum garnet laser fenestration of epidermal cysts for patients concerned about scarring, from January 2010 to July 2013, 25 patients with cosmetic concerns underwent serial laser treatment using the fenestration technique to decompress the cyst contents. "
6.	yttrium-aluminum-garnetIBA 05/01/2015 - "Erbium:yttrium aluminum garnet laser fenestration might be a promising alternative to the surgical treatment of epidermal cysts, especially when the lesions are large or located in an aesthetically important area." 05/01/2015 - "To evaluate the safety and feasibility of erbium:yttrium aluminum garnet laser fenestration of epidermal cysts for patients concerned about scarring, from January 2010 to July 2013, 25 patients with cosmetic concerns underwent serial laser treatment using the fenestration technique to decompress the cyst contents. "
7.	bleomycetinIBA 01/01/2013 - "Efficacy of pingyangmycin injection for the treatment of cervical epidermoid cysts."
8.	Keratins (Keratin)IBA 12/01/2013 - "quasimodo infestation, both cowbirds had multiple skin masses composed of epidermal cysts filled with harpirhynchid mites, keratin, and cellular debris. " 03/01/2013 - "Damage-associated molecular pattern molecules released by either ruptured epidermal cysts exposing keratin fibres or altered structural components of less maintained apocrine glands may both stimulate TLR-mediated innate immunity. " 03/01/2013 - "Deficient Notch signalling switches the fate of outer root sheath cells, resulting in conversion of hair follicles to keratin-enriched epidermal cysts. " 02/01/2013 - "Histopathologic evaluations revealed stratified squamous epithelium linings and keratin contents, which were not identical to the common epidermal or epidermoid cysts. " 10/01/2012 - "Epidermoid cysts (Keratin pearls) are benign congenital lesions, found commonly in cerebello-pontine angle, suprasellar cistern, sylvian cistern, pineal region, but they are very rare in interhemispheric fissure. "
9.	DNA (Deoxyribonucleic Acid)IBA 08/01/1998 - "In this study, HPV-57 DNA was found in three out of 18 plantar epidermoid cysts with different histological features from HPV-60-associated cysts, using PCR and Southern hybridization. " 05/01/2005 - "Five epidermoid cysts and four ridged warts that had developed on the soles of a patient were studied histologically, immunohistochemically and by DNA-DNA in situ hybridization. " 05/01/2005 - "Human papillomavirus-associated plantar epidermoid cyst related to epidermoid metaplasia of the eccrine duct epithelium: a combined histological, immunohistochemical, DNA-DNA in situ hybridization and three-dimensional reconstruction analysis." 05/01/2005 - "Histological and DNA-DNA in situ hybridization analyses demonstrated both homogeneous intracytoplasmic inclusion bodies pathognomonic for HPV 60 infection and HPV 60 DNA sequences not only in all of the epidermoid cysts and ridged warts but also in the acrosyringeal portion of an eccrine duct, with the dermal portion of which the smallest cyst had been revealed to connect by 3DR analysis. " 01/01/2003 - "We employed polymerase chain reaction and DNA sequencing analysis to characterize the PTCH gene in a Japanese nevoid basal cell carcinoma syndrome (NBCCS) patient suffering from meningioma, multiple basal cell carcinoma and epidermal cysts. "
10.	Monoclonal AntibodiesIBA 02/01/1989 - "The patterns of cytokeratin expression in the epithelium of 5 dental follicles, 7 dentigerous cysts, 5 odontogenic keratocysts, 3 nasopalatine cysts and an epidermoid cyst have been studies using a panel of monoclonal antibodies. " 01/01/1994 - "The stratified squamous epithelium of a splenic epidermoid cyst was studied with a battery of monoclonal antibodies to cytokeratin (CK) proteins. "

Therapies and Procedures

1.	Transplants (Transplant) 09/01/2012 - "At 4 months' follow-up, the graft was viable with no evidence of resorption or epidermal cyst formation. " 01/01/2010 - "Epidermoid cysts remain a rare entity in the palmoplanter distribution but also a very unusual finding within the confines of a full thickness skin graft." 05/01/2008 - "The dermal grafts developed epidermoid cysts. " 07/01/2006 - "The full thickness skin graft is not a suitable interpositional material for the TMJ because of the high risk of epidermoid cyst formation and the propensity for lateral displacement of the graft even when sutured into the appropriate intra-articular position." 12/01/1997 - "Grafts contained up to seven milia lesions between 4 and 8 mo after initiation of treatment, whereas the number of larger epidermal cysts was rarely more than two. "
2.	Lasers (Laser) 06/01/2003 - "In cosmetically sensitive areas, laser marsipulization of epidermal cysts represents a viable alternative to conventional dissection." 07/01/2009 - "A new procedure for treating a sebaceous cyst: removal of the cyst content with a laser punch and the cyst wall with a minimal postponed excision." 06/01/2003 - "Laser marsipulization of epidermal cysts: avoiding linear scars." 05/01/2015 - "Erbium:yttrium aluminum garnet laser fenestration might be a promising alternative to the surgical treatment of epidermal cysts, especially when the lesions are large or located in an aesthetically important area." 05/01/2015 - "To evaluate the safety and feasibility of erbium:yttrium aluminum garnet laser fenestration of epidermal cysts for patients concerned about scarring, from January 2010 to July 2013, 25 patients with cosmetic concerns underwent serial laser treatment using the fenestration technique to decompress the cyst contents. "
3.	Solid-State Lasers 02/01/2002 - "We report a case of a young man with several scrotum's sebaceous cysts, treated successfully with the use of a Nd-YAG laser." 05/01/2015 - "Treatment of epidermal cysts with erbium: YAG laser fenestration: an alternative to surgical intervention." 02/01/2002 - "Until today, the use of de Nd-YAG laser for the management of the scrotum's sebaceous cysts as not been reported. " 02/01/2002 - "[Nd-YAG laser photocoagulation of scrotal sebaceous cysts]."
4.	Orchiectomy (Orchidectomy) 11/01/1999 - "The ability of preoperative imaging studies to suggest the diagnosis of epidermoid cyst may prompt a testis-sparing surgery instead of an orchiectomy." 08/01/2015 - "We performed orchiectomy under the impression of an epidermal cyst. " 01/01/2014 - "We demonstrate that careful intraoperative frozen-section examination helps to avoid unnecessary orchidectomy in testicular epidermoid cysts. " 08/01/2013 - "After partial orchiectomy, the final diagnosis in three patients was epidermoid cyst. " 06/01/2008 - "We present here, a case of bilateral epidermoid cyst in which characteristic ultrasound (US) findings allowed testis-sparing enucleation instead of radical orchiectomy."
5.	Electrodes (Electrode) 02/01/1994 - "[A case of epileptic laughter associated with temporal epidermoid cyst: surgical treatment combined with subdural grid electrode study]."