Ephedrine

A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.

Also Known As:

Networked: 979 relevant articles (82 outcomes, 118 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Ngan Kee, Warwick D: 6 articles (06/2011 - 04/2002)
2.	Fernando, Roshan: 4 articles (10/2011 - 04/2005)
3.	Ngan Kee, W D: 4 articles (12/2008 - 06/2000)
4.	Lee, Anna: 4 articles (10/2008 - 04/2002)
5.	Gin, Tony: 4 articles (10/2008 - 04/2002)
6.	Greenway, Frank L: 3 articles (09/2015 - 09/2008)
7.	Khezri, Marzieh Beigom: 3 articles (06/2015 - 12/2013)
8.	Cooper, David W: 3 articles (06/2012 - 12/2002)
9.	Landau, Ruth: 3 articles (06/2011 - 09/2002)
10.	Xiao, Nong: 3 articles (11/2009 - 08/2007)

Related Diseases

1.	Hypotension (Low Blood Pressure) 01/01/2009 - "The incidence of hypotension, number of ephedrine treatments, and need for ephedrine were significantly greater in group B than group BF. " 05/01/2007 - "A median sensory level of T6 was observed in both groups but the incidence of hypotension was markedly lower in group MD when compared to group LT (4.4% vs 40%; p < 0.001) with a significant reduction in mean (SD) ephedrine requirement (6 (0) vs 11.3 (4.9) mg; p < 0.001). " 09/01/2014 - "The three drugs were effective in preventing hypotension; however, fetal effects were more frequent in the ephedrine group, although transient. " 05/01/2011 - "Prophylactic intramuscular ephedrine may be effective in reducing the incidence of hypotension in addition to conventional measures. " 09/01/2004 - "Ephedrine hydrochloride was effective for the treatment of his hypotension. "
2.	Weight Loss (Weight Reduction) 08/01/2000 - "Recently, large amounts of ma-huang were used as a source of ephedrine in many dietary supplements formulated for weight reduction, because ephedrine has been found effective in inducing weight loss in diet-restricted obese patients. " 03/26/2003 - "Ephedrine and ephedra promote modest short-term weight loss (approximately 0.9 kg/mo more than placebo) in clinical trials. " 03/26/2003 - "Two reviewers independently identified trials of efficacy and safety of ephedra and ephedrine on weight loss or athletic performance; disagreements were resolved by consensus. " 03/26/2003 - "Eligible studies were controlled trials of ephedra or ephedrine used for weight loss or athletic performance and case reports of adverse events associated with such use. " 01/01/1985 - "A double-blind controlled study was performed in unselected obese outpatients to assess the effects of ephedrine on weight loss. "
3.	Obesity 01/01/1985 - "These results do not seem to favour the hypothesis that ephedrine, a thermogenic agent, may be effective in the therapy of unselected simple obesity. " 01/01/2002 - "Safety and efficacy of ephedra and ephedrine for enhancement of athletic performance, thermogenesis and the treatment of obesity." 10/01/1989 - "Furthermore, it is concluded that additional clinical research is necessary to determine the efficacy of integrating ephedrine therapy and cognitive-behavioral psychotherapeutic procedures as adjuncts to a multidimensional program for treating obesity." 05/01/2015 - "Chronic ephedrine administration decreases brown adipose tissue activity in a randomised controlled human trial: implications for obesity." 12/01/1997 - "Although research on individuals with obesity supports the use of ephedrine for fat loss, no studies have been done on athletes. "
4.	Bradycardia 08/01/2012 - "Mothers treated with ephedrine had a lower risk for bradycardia (RR 0.17; 95%CI 0.07-0.43; P = 0.004). " 11/01/2007 - "The only problem encountered was a transient bradycardia of 40 per minute with a systolic blood pressure of 70 mmHg, which settled with ephedrine. " 06/01/2015 - "Heart rate (HR) was monitored continuously The criterion of hypotension requiring ephedrine was a decrease in systolic pressure by 20% compared to its baseline value or a decrease in systolic pressure below 90 mm Hg. The criterion of bradycardia was a decrease in HR below 60/min. Hypotension was observed in 14 group 0 patients (39%) and in 15 group P patients (44%); the difference was not statistically significant. " 01/01/2011 - "Mean height of block, Total no. of segments blocked, Onset Time of sensory block (in Minutes), ephedrine doses, incidence of hypotension & bradycardia, APGAR score at 1& 5 Minutes. " 06/01/1978 - "Both drugs produced a reflex bradycardia in the unatropinized fetus which in the case of ephedrine was followed by a tachycardia. "
5.	Pain (Aches) 01/01/2004 - "The federal ban on ephedrine dietary supplements:an important event for pain practitioners and patients." 11/01/2002 - "A small dose of ephedrine reduces the incidence and intensity of the pain without significant adverse hemodynamic effects during induction." 08/01/1999 - "The authors recorded visual analog pain score (VAPS), maternal blood pressure and heart rate, ephedrine requirements, and sedation at regular intervals and fetal heart rate tracings continuously. " 01/01/2012 - "Can ephedrine pretreatment be effective in alleviating rocuronium injection pain?" 09/01/2014 - "Efficacy of ephedrine in the prevention of vascular pain associated with different infusion rates of propofol."

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4.	Colloids (Colloid)
5.	Epinephrine (Adrenaline)
6.	Lidocaine (Xylocaine)
7.	crystalloid solutions
8.	Theophylline (Theon)
9.	Atropine (Hyoscyamine)
10.	Scopolamine (Hyoscine)

Related Therapies and Procedures

1.	Spinal Anesthesia
2.	Cesarean Section (Caesarean Section)
3.	Anesthesia
4.	Epidural Anesthesia
5.	Intravenous Injections