Eosinophilic Granuloma

The most benign and common form of Langerhans-cell histiocytosis which involves localized nodular lesions predominantly of the bones but also of the gastric mucosa, small intestine, lungs, or skin, with infiltration by EOSINOPHILS.

Also Known As:

Eosinophilic Granulomas; Granulomas, Eosinophilic; Granuloma, Eosinophilic

Networked: 243 relevant articles (12 outcomes, 10 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Granuloma
3.	Disease Progression
4.	Ulcer
5.	Papilloma (Papillomatosis)

Experts

1.	Mavrogenis, Andreas F: 3 articles (06/2012 - 03/2011)
2.	Ruggieri, Pietro: 3 articles (06/2012 - 03/2011)
3.	Tang, Wang-Xian: 2 articles (06/2016 - 01/2013)
4.	Wang, Mi: 2 articles (06/2016 - 01/2013)
5.	Rimondi, Eugenio: 2 articles (06/2011 - 03/2011)
6.	Rossi, Giuseppe: 2 articles (06/2011 - 03/2011)
7.	Ussia, Giuseppe: 2 articles (06/2011 - 03/2011)
8.	Arai, Hajime: 2 articles (05/2009 - 03/2002)
9.	Misaki, Hirofumi: 2 articles (05/2009 - 03/2002)
10.	Naiki, Hironobu: 2 articles (05/2009 - 03/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Eosinophilic Granuloma:

1.	Adrenal Cortex Hormones (Corticosteroids)IBA 07/01/2008 - "Solitary forms (eosinophilic granuloma) and limited multilocational lesions may be treated successfully with local surgical intervention and intralesional corticosteroid injection. " 06/01/2011 - "CT-guided corticosteroid injection for solitary eosinophilic granuloma of the spine." 03/11/2011 - "To the best of our knowledge, this is the first case of successful treatment of a bifocal eosinophilic granuloma with CT-guided corticosteroid injection. " 03/11/2011 - "Successful treatment of a bifocal eosinophilic granuloma of the spine with CT-guided corticosteroid injection." 03/01/2007 - "Eosinophilic granuloma of the skin: response to intralesional corticosteroid injection."
2.	SteroidsIBA 10/01/1998 - "Intralesional instillation of steroids is currently the first choice of treatment for eosinophilic granuloma of bone. " 12/01/1996 - "This case is presented in light of the cytologic, histologic and immunohistochemical findings of node-based eosinophilic granuloma and the favorable prognosis of this localized form treated with steroids." 03/01/1992 - "Eosinophilic granuloma of the ischium: long-term evaluation of a patient treated with steroids. " 05/01/1991 - "Intralesional steroid in the treatment of an orbital eosinophilic granuloma." 03/01/1989 - "Treatment for solitary eosinophilic granuloma of the mandible by steroid injection: report of a case."
3.	CytokinesIBA 01/01/1995 - "TGP-specific lymphocyte proliferation, and cytokine production in vitro, were measured in three patients with pulmonary eosinophilic granuloma in remission and in three closely matched normal subjects with similar smoking histories. " 08/01/1999 - "In addition, in view of the functionally different helper T cell subsets now identified, the existing DTH response is redefined as DTH Type 1 (Th-1 mediated) and two new classes of T cell-dependent DTH responses are proposed; DTH Type II, associated with the Th-2 type cytokines IL-4 and IL-5 and eosinophilic granuloma formation, and DTH Type III, associated with IL-4 and TGF-beta and fibrosis. "
4.	InterferonsIBA 04/01/2004 - "The advent of veterinary-licensed products containing recombinant interferon may enable demonstration of the efficacy of interferons for conditions such as canine papillomatosis and feline eosinophilic granuloma complex. " 09/01/2016 - "Considering the immune system dysfunction in unifocal orbital eosinophilic granuloma; possible complications of surgery, intralesional steroid, and radiotherapy; immunomodulatory and cytoreductive effects of interferon-α2b; and its safety profile in treatment of ocular surface neoplasia, intralesional interferon-α2b was first commenced in treatment of 3 cases (8-, 25-, and 43-year-old men) with biopsy proven orbital eosinophilic granuloma (2007-2014). "
5.	Methotrexate (Mexate)FDA LinkGeneric 11/15/1977 - "[Multiple eosinophilic granuloma of bone in an adult cured with intravenous methotrexate]."
6.	Zoledronic Acid (Zometa)FDA Link 02/01/2013 - "Conclusion; We have cured the severe back pain of a 10-year-old girl case of eosinophilic granuloma with zoledronic acid. "
7.	S100 Proteins (S 100 Protein)IBA 12/01/2012 - "On immunological studies, the diagnosis of eosinophilic granuloma was facilitated by diffuse immunoreactivity of S-100 protein and CD1a. " 04/15/2014 - "Excisional biopsy of the neck lesion revealed proliferated histiocytes admixed with numerous eosinophils and multinucleated giant cells that simulate eosinophilic granuloma; however, the histiocytes were negative for CD1a, CD123 and S-100 protein and positive for CD68 and CD14. " 05/01/2009 - "A biopsy specimen from the left iliac bone revealed an infiltration of S-100 protein-positive histiocyte-like cells intermingled with eosinophils, which confirmed the diagnosis of eosinophilic granuloma, a type of LCH. " 07/01/1986 - "Immunoperoxidase staining for S-100 protein in the diagnosis of eosinophilic granuloma of lung." 02/15/1988 - "Reticulum histiocytic cells of eosinophilic granulomas and chordoma cells were positive for S-100 protein. "
8.	CollagenIBA 12/01/2003 - "The purpose of this study was to investigate the ultrastructural appearance of flame figures, reported to comprise a mixture of degenerate collagen and degranulated eosinophils, in feline eosinophilic granuloma complex (EGC). " 01/01/2019 - "The eosinophilic granuloma and collagen deposition were found around the eggs in mice infected for 6 and 10 weeks. " 03/01/2000 - "In addition, evaluation of trichrome-stained specimens suggested that there is no collagen degeneration in equine and feline eosinophilic granulomas and that the areas previously referred to as collagen degeneration are more appropriately called flame figures." 09/15/1979 - "Lytic activity of eosinophilic granuloma and other tumours was studied in vitro on collagen substrate. " 03/01/2000 - "A retrospective study was performed on skin biopsy specimens from horses and cats having eosinophilic granulomas with 'collagen degeneration', eosinophilic skin diseases without 'collagen degeneration' and pyogranulomas without 'collagen degeneration'. "
9.	EnzymesIBA 12/01/1964 - "A histochemical study of hydrolytic and oxidative enzymes in an eosinophilic granuloma of parotid gland region." 01/01/1992 - "An eosinophilic granuloma has been investigated by means of histochemical proofs for enzymes and tissue elements and common staining methods. " 01/01/1991 - "By means of the proof for the enzyme phenol oxidase (PO; EC 1.14.18.1) was investigated, whether the eosinophilic granuloma correspond to a cell mediated immunological defence reaction. " 01/01/2013 - "Although elevated biliary enzymes occurring with CSS was thought to be due to a bile duct eosinophilic granuloma, we cannot rule out the possibility of IgG4-related sclerosing cholangitis, because of her elevated IgG4." 11/15/1984 - "Biopsy material of six patients with eosinophilic granuloma (EG) was investigated by electron microscopic and enzyme-histochemical methods for acid phosphatase (AcP), leucyl-beta-naphthylamidase (LA), adenosine triphosphatase, and alpha-naphthyl-acetate esterase (NE). "
10.	Adrenocorticotropic Hormone (ACTH)FDA Link 02/01/1953 - "[Eosinophilic granuloma treated by ACTH; clinical, histologic and radiologic study]." 08/01/1957 - "Treatment of eosinophilic granuloma by corticotropin: report of 4 cases with disappearance of the bone lesions." 01/24/1953 - "Corticotropin in eosinophilic granuloma."

Therapies and Procedures

1.	Therapeutics 01/01/1993 - "Diagnosis of eosinophilic granuloma of bone by fine-needle aspiration with concurrent institution of therapy: a cytologic, histologic, clinical, and radiologic study of 27 cases." 05/01/2004 - "This case report describes the incidence, clinical significance, background and therapy of an eosinophilic granuloma of the spine." 03/01/2003 - "Treatment of recurrent eosinophilic granuloma with systemic therapy." 07/01/2002 - "In most cases of cervical eosinophilic granuloma, immobilization is an adequate therapy. " 07/01/2002 - "All reported cases of cervical eosinophilic granuloma were analyzed concerning age and sex distribution, clinical and radiologic presentation, therapy, and outcome. "
2.	Radiotherapy 01/01/1992 - "An isolated eosinophilic granuloma at the craniocervical junction was treated by an extreme lateral surgical excision, bone grating, and radiotherapy with good outcome." 01/01/2016 - "Eosinophilic granuloma of the sacrum treated with radiation therapy: a case report." 01/01/2007 - "Primary solitary eosinophilic granuloma of the brain and postoperative radiotherapy: a clinical case." 01/01/2005 - "The author's present a case of a patient with unifocal eosinophilic granuloma limited to the mastoid treated in ENT and radiotherapy departments. " 01/01/2000 - "We present the results of two female adults with eosinophilic granuloma of bone who underwent conventionally fractionated radiation therapy with total doses of 7 x 1.8 Gy and 7 x 2.0 Gy in four different sites. "
3.	Curettage 07/01/1997 - "This paper related a case of eosinophilic granuloma in an eleven-year-old male child, treated successfully with curettage. " 09/01/2019 - "According to the results, it can be concluded that surgical curettage of localized eosinophilic granuloma is an appropriate and sufficient treatment." 01/01/2017 - "Spontaneous and complete regeneration of a vertebra plana after surgical curettage of an eosinophilic granuloma." 01/01/1992 - "In single eosinophilic granuloma, curettage was associated with biopsy. " 08/01/1980 - "Manifesting itself usually within a single bone, eosinophilic granuloma of bone is a benign entity which readily lends itself to cure by surgical curettage, low-dosage irradiation, or a combination of the two. "
4.	Cryosurgery 10/15/1978 - "The use of cryosurgery in treatment of eosinophilic granuloma in cats is described. " 01/01/2000 - "Cryosurgery is an effective treatment for readily recurrent eosinophilic granuloma facial and should be proposed as first intention therapy." 10/01/1998 - "Eosinophilic granuloma of bone: results of treatment with curettage, cryosurgery, and bone grafting."
5.	Drug Therapy (Chemotherapy) 01/01/2011 - "We present a case of eosinophilic granuloma of the rib with long term follow-up of 14 years which was treated with a combination of surgery and chemotherapy. " 09/01/2007 - "Focal forms such as eosinophilic granuloma of the bone only require minimal care but the gravity of multisystem forms causing organic dysfunction sometimes require aggressive chemotherapy. " 07/01/2007 - "Polyostotic eosinophilic granuloma of the jaws treated by chemotherapy. " 04/01/2002 - "After chemotherapy, all signs of eosinophilic granuloma subsided, but focal fibrocartilaginous dysplasia remained without signs of clinical or radiographic progression. " 03/01/2000 - "One clinical case of pulmonary eosinophilic granuloma were followed-up during 10 months of chemotherapy. "