Enzymes

Biological molecules that possess catalytic activity. They may occur naturally or be synthetically created. Enzymes are usually proteins, however CATALYTIC RNA and CATALYTIC DNA molecules have also been identified.

Also Known As:

Networked: 152586 relevant articles (3757 outcomes, 13939 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bolognesi, Claudia: 230 articles (07/2022 - 01/2017)
2.	Grob, Konrad: 226 articles (07/2022 - 01/2017)
3.	Tlustos, Christina: 226 articles (07/2022 - 01/2017)
4.	Zorn, Holger: 224 articles (07/2022 - 01/2017)
5.	Chesson, Andrew: 179 articles (07/2022 - 05/2017)
6.	Crebelli, Riccardo: 174 articles (07/2022 - 01/2017)
7.	Cocconcelli, Pier Sandro: 173 articles (07/2022 - 01/2005)
8.	Gott, David Michael: 172 articles (07/2022 - 08/2018)
9.	Lampi, Evgenia: 172 articles (07/2022 - 08/2018)
10.	Mortensen, Alicja: 172 articles (07/2022 - 08/2018)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2017 - "In 2005 and 2006, inhibiting PARP enzymes was first observed to be highly effective against cancers with HR deficiencies. " 03/28/2006 - "At his most recent visit in May 2005, the patient was asymptomatic, liver enzymes were normal and the tumor was in remission on ultrasound." 03/08/2006 - "Eventually, this may help to truly individualize the dosing of this (and other) anti-cancer agent(s), using a personal genetic profile of the most relevant enzymes for every patient." 11/01/1987 - "The detection of tumor cells in cultures of lung minces appeared to be the most sensitive of these methods and the determination of enzyme in lung lysates seemed to hold most promise for a quantitative approach. " 01/01/2018 - "Inhibition of key enzymes in glycolysis and glutaminolysis pathways with small molecules has provided a novel but emerging area of cancer research and has been proven effective in slowing the proliferation of cancer cells, with several inhibitors being in clinical trials. "
2.	Infections 01/01/2023 - "Treatments that target Neu-1 are predicted to be highly effective against infection with SARS-CoV-2, given the central role played by this enzyme in viral cellular entry and the induction of the CRS." 10/15/2016 - "Neutrophils play a major role in combatting infection; they can act as phagocytes as well as produce and release lytic enzymes that have potent antimicrobial effects leading to the destruction and clearance of bacterial pathogens. " 07/20/2023 - "When Aq was used during infection, a significant reduction in H2O2 was observed concomitant with a significant increase in the levels of CAT and SOD enzymes. " 10/26/2016 - "By introducing this barrier, which the virus must breach using its NA enzymes to infect a host cell, into a screening platform, we have been able to identify compounds that provide significant protection against IAV infection. " 11/01/2002 - "Although there has been significant improvement in the enzyme immunoassays (EIAs) in population screening of HCV infection, the development of a low variability, easy to automate and inexpensive supplemental test to support the current immunoassays was of a major concern to several laboratories. "
3.	Inflammation (Inflammations) 01/01/2019 - "Application of the Cochrane Collaboration's tool 10-item checklist and Rev-Man 5.3 software to analyze risk of bias of studies and data on outcome measures revealed study quality scores ranging from 2 to 5. Compared with the control group, AS-IV induced a marked decrease in mortality (P < 0.05), inflammation of myocardium and pathological score (P< 0.05) and cardiac enzymes expression (P< 0.05), and improved the function of the heart (P< 0.05). " 01/01/2015 - "Therefore, we evaluated the efficacy of a Food Supplement (FS) containing enzymes which is commonly used in various inflammatory processes and is able to modulate immune reactions during inflammation in a very rapid and efficacious way. " 12/01/2006 - "Moreover, hepatic enzyme levels normalized and histological findings indicated marked improvement in hepatic inflammation. " 11/30/2023 - "Liver function, coagulation function, inflammation, oxidative stress and mitochondrial enzyme activity were significantly improved by JDNWF. " 08/01/2002 - "Application of GLP significantly mitigated hepatic tumefaction, decreased ALT enzyme release and NO production in serum/supernatant, improved the pathological changes of chronic and acute inflammation induced by BCG-stimuli in mice. "
4.	Body Weight (Weight, Body) 11/01/2023 - "Our results showed a significant improvement (P < 0.05) in body weight gain, feed conversion ratio, nutrient digestibility, and digestive enzymes activities in broilers fed on PC, CEO, and PRO compared to the control group. " 01/01/2022 - "Multi-enzymes significantly improved body weight gain and the production index (PI) relative to the SD. " 01/01/2022 - "melanogaster, increased body weight, and improved the body's antiaging enzyme activity but also effectively improved the types and quantities of beneficial bacteria in the intestinal flora of InR[E19]/TM2 D. " 11/21/2020 - "Similarly, body weight, feed intake, and FCR were significantly (P < 0.05) improved in enzyme-treated birds compared to the untreated birds. " 11/01/2020 - "Providing NLC as a dietary supplement at the concentrations of 2.5 and 5 mg/kg mice body weight significantly (p ≤ 0.05) improved the feed intake and body weight gain, modulated the liver enzymes, and alleviated the hepatic oxidative stress. "
5.	Insulin Resistance 11/01/2014 - "The main aim of this study was to investigate whether RT induces changes in endothelial enzymes of the muscle microvasculature, which would increase NO bioavailability and could contribute to improved insulin sensitivity. " 01/01/2023 - "Liver enzymes, insulin resistance, and metabolic parameters were also improved. " 01/01/2022 - "Blood pressure, insulin resistance, and liver enzymes improved. " 03/28/2020 - "The euglycemic-hyperinsulinemic clamp helped assess insulin sensitivity, and the enzyme immunometric assay was deployed for ZAG levels. " 05/01/2017 - "Insulin resistance and liver enzymes were improved in BBR treated rats. "

Related Drugs and Biologics

1.	Antioxidants
2.	Immunosorbents
3.	Proteins (Proteins, Gene)
4.	Enzymes
5.	Lipids
6.	Glucose (Dextrose)
7.	Antigens
8.	Cytokines
9.	Prodrugs
10.	Superoxide Dismutase

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Enzyme Replacement Therapy
4.	Oral Administration
5.	Transplantation