Enterovirus Infections

01/01/2002 - "The future holds promise for effective antiviral drugs that can treat enterovirus infections and decrease their significant morbidity and mortality."
01/01/2023 - "Better methods to study enterovirus infection in live cells will help us better understand the pathogenesis of these viruses and might contribute to antiviral development. "
01/01/2023 - "Therefore, integration of these reporters with modern image-based analysis has the potential to generate new insights into enterovirus infection and facilitate antiviral development."
01/31/2022 - "Currently, effective antiviral agents are not available for the treatment or prevention of enterovirus infections, which remain an important threat to public health. "
01/01/2022 - "This mini-review characterizes the essential role of host restriction factors in enterovirus infections, which provides ideas and potential targets for antiviral drug design by regulating host restrictive factors. "

01/01/2022 - "Here, we developed a neonatal mouse model of enterovirus infection by the enteral route using echovirus 5 and used this model to define the differential roles of type I and III interferons (IFNs) in enterovirus replication in the intestinal epithelium and subsequent dissemination to secondary tissues. "
05/01/1969 - "[Interferon production in healthy children and in those ill with acute respiratory and enterovirus infections. "
01/01/1969 - "[Interferon formation in healthy children and in those ill with acute respiratory and enterovirus infections. "
01/01/1996 - "Evaluation of specific antiviral agents, for example interferons, may lead to the development of new therapeutic strategies capable of providing protection against myocardial enterovirus infection."
08/01/1993 - "Evaluation of specific antiviral agents, for example interferons, may lead to the development of new therapeutic strategies capable of providing protection against myocardial enterovirus infection."

11/27/1999 - "EARLY TRIALS WITH PLECONARIL: Pleconaril is active against picomaviruses and appears to have interesting efficacy against exceptionally severe enterovirus infections. "
07/01/2006 - "Of 607 randomized patients in a multicenter, double-blind placebo-controlled study of pleconaril (200 mg three times daily versus an identical-appearing placebo), 240 patients were confirmed to have enterovirus infection. "
03/01/2015 - "Pleconaril is a capsid inhibitor used previously to treat enterovirus infections. "
01/15/2001 - "Treatment of potentially life-threatening enterovirus infections with pleconaril."
01/15/2001 - "Pleconaril was used on a compassionate-release basis to treat patients with potentially life-threatening enterovirus infections, and for 38 of these patients sufficient follow-up data were available for determining responses to therapy. "

05/01/2001 - "We could show that in acute enterovirus infections, virus detection by cell cuLture and PCR is superior to serological methods (neutralization assay and IgM assay). "
05/01/2004 - "Although this study did not have enough power to reveal intrauterine exposure to maternal enterovirus infection during pregnancy as a risk factor for development of AIT during childhood and adolescence, it suggested an association with earlier onset of clinical disease in children to enterovirus IgM-seropositive mothers."
01/01/2007 - "One patient (2.08%) had evidence of enterovirus infection by RT-PCR, 3 patients (6.25%) had EBV IgM, and none were positive for CMV IgM. "
08/01/2003 - "Serology for enterovirus IgM antibody can be useful for convalescent diagnosis of enterovirus infection in the mother, especially with earlier serum for comparison."
05/01/1999 - "In addition, enterovirus infections were searched for using an enterovirus group-reacting IgM test. "

10/01/2000 - "EV RNA was detected in all 30 culture-confirmed CSF samples and yielded positive results in 5 out of 7 additional cases of culture-negative CSF samples with other evidences of enterovirus infection. "
01/01/2020 - "Our studies provide the first lines of evidence to suggest that either negative- or positive-strand RNA synthesis (or both) is a likely candidate for the step that requires the removal of VPg from the RNA for an enterovirus infection to proceed efficiently."
04/01/2004 - "The study shows that after the onset of symptomatic respiratory infection enterovirus RNA may take 2-3 weeks and rhinovirus RNA 5-6 weeks to disappear from nasal mucus."
10/01/2000 - "In this study, we have tested a reverse transcription (RT) nested polymerase chain reaction (nPCR) for detection of enterovirus (EV) RNA in cerebrospinal fluid (CSF), serum samples, and conjunctival swabs (CS) from patients with suspected enterovirus infections. "
01/01/2020 - "Structures and Functions of Viral 5' Non-Coding Genomic RNA Domain-I in Group-B Enterovirus Infections."

04/01/2013 - "Our study shows that maternally transferred antibodies protect offspring from enterovirus infection and virus-induced diabetes. "
10/01/1989 - "Although the number of patients in this study is small, the results suggest that intrathecally synthesized enterovirus-specific antibodies may be used as a means of identifying an enterovirus infection of the CNS."
01/01/2022 - "Detection of intrathecal antibodies to diagnose enterovirus infections of the central nervous system."
04/01/2015 - "Thus, the panel of in-house anti-enterovirus polyclonal antibodies described herein will be an important tool for the screening and pathological diagnosis for enterovirus infections, and may be useful for the classification of different enterovirus serotypes, including coxsackieviruses A and B, echoviruses, enterovirus A71 and poliovirus."
04/01/2015 - "Establishment of a panel of in-house polyclonal antibodies for the diagnosis of enterovirus infections."

01/01/2011 - "Accumulating data suggest that the T1D disease process may be triggered by a diabetogenic enterovirus infection and driven by a dietary antigen. "
01/01/1999 - "Recent prospective studies have indicated that enterovirus infections may induce beta-cell autoimmunity and potentiate the humoral immune response to beta-cell antigens in subjects with an ongoing process. "
03/01/1998 - "By the age of 6 months, 68% of the infants had developed T-cell responses against enterovirus antigens by lymphocyte proliferation test, whereas only 30% had serological evidence of an enterovirus infection. "
09/01/1992 - "In conclusion, the use of a single antigen-based ELISA was found to be reliable for the diagnosis of recent and current enterovirus infections."
05/01/1988 - "In 91 sera from enterovirus infections diagnosed by virus isolation 11/40, 16/28 and 9/23 were positive in SPRIST against ECHO 3 and/or Coxsackie B3 antigen during the first, during the second and third, and after 3 weeks of illness, respectively. "

11/01/2016 - "This is the first report to describe the use of fluoxetine as a potential therapy for chronic enterovirus infection. "
09/01/2012 - "In view of its favorable pharmacokinetics and safety profile, fluoxetine warrants additional study as a potential antiviral agent for enterovirus infections."
10/01/2022 - "Enterovirus infections pose a serious threat for patients with humoral deficiencies and may be lethal, whilst the efficacy of proposed treatment options such as corticosteroids, intravenous immunoglobulins and fluoxetine remains debated. "

05/01/1989 - "In this study, the efficacy of the antienterovirus (and antipicornavirus) drug disoxaril was demonstrated in a murine model of persistent enterovirus infection. "
12/15/1993 - "The procapsids are useful in serological diagnosis of enterovirus infections, and the addition of disoxaril facilitates this technique."
01/01/1986 - "The potent in vitro and in vivo anti-picornavirus activity of WIN 51711 makes it a potentially useful drug for the treatment of enterovirus infections in humans."
05/01/1989 - "Clearance of a persistent human enterovirus infection of the mouse central nervous system by the antiviral agent disoxaril."

02/01/1996 - "Neonatal enterovirus infection: neutralization by intravenous immune globulin."
05/01/1995 - "Neonatal enterovirus infection: virology, serology, and effects of intravenous immune globulin."
09/01/2023 - "Neonatal enterovirus infections can vary in how they respond to IVIG therapy. "
08/01/2015 - "Intravenous immune globulin (IVIG) has been used to treat enterovirus infections in neonates and is an accepted replacement therapy for immunodeficient patients. "
03/01/2015 - "The benefits of intravenous immunoglobulin (IVIG) therapy for severe neonatal enterovirus infections are still controversial. "

12/01/2015 - "Chemotherapy is an important tool for controlling enterovirus infections, but clinically effective anti-enterovirus drugs do not currently exist, mainly due to the development of drug resistance. "
12/01/2015 - "These results add new support for using consecutive alternating administration treatment courses to achieve clinically effective chemotherapy of enterovirus infections."
11/23/2020 - "All data obtained prove the potential of the CAA treatment scheme for development of effective chemotherapy of enterovirus infections."
01/01/2015 - "The above mentioned diseases along with the significantly high morbidity and mortality in children, as well as in the high-risk populations (immunodeficiencies, neonates) definitely formulate the chemotherapy as the main tool for the control of enterovirus infections. "
07/01/2021 - "Although chemotherapy is generally indicated for treatment of enterovirus infections, antivirals are currently not used in clinical practice. "

09/01/2023 - "The majority of enterovirus infections are self-limited, require no special therapy, and only little supportive care is required. "
08/28/2020 - "High-dose intravenous therapy should be considered as treatment for severe enterovirus infection. "
06/01/2011 - "Towards the design of combination therapy for the treatment of enterovirus infections."
01/01/2018 - "We report the clinical presentation, the diagnostic steps, the therapy as well as the long-term progression of a preterm infant who acquired a perinatal enterovirus infection including viral myocarditis. "
01/01/1994 - "These results indicate that an enterovirus infection may be clinically useful for the therapy of human ovarian cancers with bad prognoses."

12/01/2023 - "Assessment of the Clinical Course of Human Rhinovirus/Enterovirus Infections in Pediatric Intensive Care."
11/17/2015 - "There was no significant difference in admission to the critical care unit or death among children with EV-D68 infection compared with those with other rhinovirus or enterovirus infections (adjusted OR 1.47, 95% CI 0.61-3.52). "

01/01/2017 - "Here, using coxsackievirus B1 (CVB1) as a prototype enterovirus strain, we demonstrate that human enterovirus infection, replication and infectious virus production can be analyzed in vitro in a human Gut-on-a-Chip microfluidic device that supports culture of highly differentiated human villus intestinal epithelium under conditions of fluid flow and peristalsis-like motions. "

07/01/2006 - "Causes of death included disseminated enterovirus infection (n = 6), pulmonary insufficiency (n = 5), adenovirus infection (n = 1), sepsis (n = 1), acquired immunodeficiency disease syndrome (AIDS) (n = 1), myocarditis (n = 1), hepatitis (n = 2), and stem cell transplantation (n = 1)."