Enterovirus Infections

01/01/2002 - "The future holds promise for effective antiviral drugs that can treat enterovirus infections and decrease their significant morbidity and mortality."
02/01/2001 - "New antiviral drugs have been developed that inhibit enterovirus replication, and early clinical trials of these compounds suggest that effective therapy for enterovirus infections is now possible."
09/01/2012 - "No antiviral drugs currently exist for the treatment of enterovirus infections, which are often severe and potentially life threatening. "
12/01/2003 - "Rapid detection of enterovirus infection is essential in taking the decision for treatment with antiviral agents and applying infection control measures in hospitalized pediatric patients. "
03/01/2000 - "Although poliovirus infection may be eradicated from the world due to the efficient vaccination program, there is no specific antiviral agents for either treatment or prevention for other enterovirus infections. "

05/01/1969 - "[Interferon production in healthy children and in those ill with acute respiratory and enterovirus infections. "
01/01/1969 - "[Interferon formation in healthy children and in those ill with acute respiratory and enterovirus infections. "
01/01/1996 - "Evaluation of specific antiviral agents, for example interferons, may lead to the development of new therapeutic strategies capable of providing protection against myocardial enterovirus infection."
08/01/1993 - "Evaluation of specific antiviral agents, for example interferons, may lead to the development of new therapeutic strategies capable of providing protection against myocardial enterovirus infection."
01/01/1993 - "Evaluation of specific antiviral agents, for example interferons, may lead to the development of new therapeutic strategies capable of providing protection against myocardial enterovirus infection."

05/01/2001 - "We could show that in acute enterovirus infections, virus detection by cell cuLture and PCR is superior to serological methods (neutralization assay and IgM assay). "
05/01/2004 - "Although this study did not have enough power to reveal intrauterine exposure to maternal enterovirus infection during pregnancy as a risk factor for development of AIT during childhood and adolescence, it suggested an association with earlier onset of clinical disease in children to enterovirus IgM-seropositive mothers."
12/01/2007 - "Recent enterovirus infection in type 1 diabetes: evidence with a novel IgM method."
01/01/2007 - "One patient (2.08%) had evidence of enterovirus infection by RT-PCR, 3 patients (6.25%) had EBV IgM, and none were positive for CMV IgM. "
08/01/2003 - "Serology for enterovirus IgM antibody can be useful for convalescent diagnosis of enterovirus infection in the mother, especially with earlier serum for comparison."

04/01/2013 - "Our study shows that maternally transferred antibodies protect offspring from enterovirus infection and virus-induced diabetes. "
10/01/1989 - "Although the number of patients in this study is small, the results suggest that intrathecally synthesized enterovirus-specific antibodies may be used as a means of identifying an enterovirus infection of the CNS."
04/01/2015 - "Thus, the panel of in-house anti-enterovirus polyclonal antibodies described herein will be an important tool for the screening and pathological diagnosis for enterovirus infections, and may be useful for the classification of different enterovirus serotypes, including coxsackieviruses A and B, echoviruses, enterovirus A71 and poliovirus."
04/01/2015 - "Establishment of a panel of in-house polyclonal antibodies for the diagnosis of enterovirus infections."
09/01/2011 - "We aimed to analyse the occurrence of enterovirus infections in 55 infants and to assess the protection provided by maternal antibodies to these children and the development of enterovirus antibodies in a prospective cohort study. "

10/01/2000 - "EV RNA was detected in all 30 culture-confirmed CSF samples and yielded positive results in 5 out of 7 additional cases of culture-negative CSF samples with other evidences of enterovirus infection. "
04/01/2004 - "The study shows that after the onset of symptomatic respiratory infection enterovirus RNA may take 2-3 weeks and rhinovirus RNA 5-6 weeks to disappear from nasal mucus."
10/01/2000 - "In this study, we have tested a reverse transcription (RT) nested polymerase chain reaction (nPCR) for detection of enterovirus (EV) RNA in cerebrospinal fluid (CSF), serum samples, and conjunctival swabs (CS) from patients with suspected enterovirus infections. "
08/01/2003 - "Although the infrastructure established for PCR-based screening for HCV RNA would allow parallel screening for enteroviruses, any decision concerning donor testing would require further information on the outcome of transfusion-acquired enterovirus infections."
08/01/2002 - "Rapid detection of enterovirus infection by automated RNA extraction and real-time fluorescence PCR."

06/01/2012 - "Enterovirus infections may be involved in the etiology of type 1 diabetes (T1D), which is strongly associated with certain human leukocyte antigen (HLA) class II haplotypes. "
01/01/2012 - "Poor fitness of gut microbiota could explain why children who develop type 1 diabetes are prone to enterovirus infections, and do not develop tolerance to cow milk antigens. "
01/01/2011 - "Accumulating data suggest that the T1D disease process may be triggered by a diabetogenic enterovirus infection and driven by a dietary antigen. "
01/01/1999 - "Recent prospective studies have indicated that enterovirus infections may induce beta-cell autoimmunity and potentiate the humoral immune response to beta-cell antigens in subjects with an ongoing process. "
03/01/1998 - "By the age of 6 months, 68% of the infants had developed T-cell responses against enterovirus antigens by lymphocyte proliferation test, whereas only 30% had serological evidence of an enterovirus infection. "

11/27/1999 - "EARLY TRIALS WITH PLECONARIL: Pleconaril is active against picomaviruses and appears to have interesting efficacy against exceptionally severe enterovirus infections. "
07/01/2006 - "Of 607 randomized patients in a multicenter, double-blind placebo-controlled study of pleconaril (200 mg three times daily versus an identical-appearing placebo), 240 patients were confirmed to have enterovirus infection. "
03/01/2015 - "Pleconaril is a capsid inhibitor used previously to treat enterovirus infections. "
01/15/2001 - "Pleconaril was used on a compassionate-release basis to treat patients with potentially life-threatening enterovirus infections, and for 38 of these patients sufficient follow-up data were available for determining responses to therapy. "
01/15/2001 - "Treatment of potentially life-threatening enterovirus infections with pleconaril."

05/01/1989 - "In this study, the efficacy of the antienterovirus (and antipicornavirus) drug disoxaril was demonstrated in a murine model of persistent enterovirus infection. "
05/01/1989 - "Clearance of a persistent human enterovirus infection of the mouse central nervous system by the antiviral agent disoxaril."
12/15/1993 - "The procapsids are useful in serological diagnosis of enterovirus infections, and the addition of disoxaril facilitates this technique."
01/01/1986 - "The potent in vitro and in vivo anti-picornavirus activity of WIN 51711 makes it a potentially useful drug for the treatment of enterovirus infections in humans."

05/01/1988 - "The corresponding figures for 85 sera from enterovirus infections diagnosed by a greater than or equal to 4-fold rise in complement fixing (CF) antibody titre against antigen from ECHO 18 and/or Coxsackie B5 antigen were 10/39, 12/20 and 9/26. "
12/01/1994 - "However, the prevalence of serum polymeric IgA antibodies against coxsackie B5 antigen was significantly greater (P = 0.02) in patients with an acute enterovirus infection (57%) than in patients with other infections (18%). "

03/01/1998 - "These results further suggested that RCA sensitivity could be improved by a factor of at least 10 times by prolonging the incubation period by 24 hr. With this change, the RCA assay described below is suggested as a rapid alternative to CCA for the routine diagnosis of enterovirus infection in stool specimens. "
01/01/2011 - "It is concluded that enterovirus infection is a factor of ACS; it is directly involved in its pathogenesis and promotes the development of cardiogenic shock and/or cardiac rupture."

01/01/2015 - "Here, we discuss recent advances from studies on the role of structural proteins in enterovirus infection and antiviral therapeutics targeted structural proteins. "

07/01/2006 - "Causes of death included disseminated enterovirus infection (n = 6), pulmonary insufficiency (n = 5), adenovirus infection (n = 1), sepsis (n = 1), acquired immunodeficiency disease syndrome (AIDS) (n = 1), myocarditis (n = 1), hepatitis (n = 2), and stem cell transplantation (n = 1)."

02/01/2004 - "Although enteroviruses tended to be more frequent in TBI-based conventional conditioning recipients, the only significant risk factor for enterovirus infection was unrelated donor graft. "
02/01/2004 - "Seven patients (10.4%) developed nine episodes of enterovirus infections at a median of 146 days post transplant. "
02/01/2004 - "Enterovirus infections following T-cell depleted allogeneic transplants in adults."

05/01/2004 - "These results provide further evidence of enterovirus involvement in a high proportion of DCM cases and demonstrate that VP1 is present in disease stages from acute myocarditis, healing myocarditis to end-stage DCM requiring cardiac transplantation, indicating translation of viral protein during persistent enterovirus infection."

03/01/1999 - "Pulmonary enterovirus infections in stem cell transplant recipients."