Glucagon-Like Peptides (Enteroglucagon)

Peptides derived from proglucagon which is also the precursor of pancreatic GLUCAGON. Despite expression of proglucagon in multiple tissues, the major production site of glucagon-like peptides (GLPs) is the INTESTINAL L CELLS. GLPs include glucagon-like peptide 1, glucagon-like peptide 2, and the various truncated forms.

Also Known As:

Networked: 424 relevant articles (21 outcomes, 38 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Holst, Jens J: 9 articles (05/2022 - 12/2003)
2.	Holst, J J: 7 articles (06/2017 - 01/2000)
3.	Drucker, Daniel J: 6 articles (01/2020 - 07/2002)
4.	van Raalte, Daniël H: 5 articles (10/2020 - 11/2015)
5.	Deacon, Carolyn F: 4 articles (05/2022 - 03/2012)
6.	Diamant, Michaela: 4 articles (12/2016 - 02/2014)
7.	Muskiet, Marcel H A: 4 articles (12/2016 - 02/2014)
8.	Smits, Mark M: 4 articles (12/2016 - 02/2014)
9.	Hartmann, Bolette: 3 articles (05/2022 - 12/2003)
10.	Wang, Ming-Wei: 3 articles (12/2020 - 01/2007)

Related Diseases

1.	Type 2 Diabetes Mellitus (MODY) 01/01/2018 - "Better adherence, powered by recent technological advances in the delivery of glucagon-like peptide 1-receptor agonists, may thus lead to improved clinical outcomes in type 2 diabetes." 08/01/2023 - "Glucagon-like peptide (GLP)-1 receptor agonists are used in the treatment of type 2 diabetes (T2DM), but their effects on AF in T2DM are poorly understood. " 01/01/2022 - "The therapeutic arsenal for treating type 2 diabetes mellitus (T2DM) has been enriched recently with the inclusion of type 1 glucagon-like peptide (GLP-1). " 06/01/2015 - "Glucagon-like polypeptide agonists in type 2 diabetes mellitus: efficacy and tolerability, a balance." 01/01/2015 - "Glucagon like peptide (GLP-1) analogues are a relatively novel medication developed primarily for the treatment of type 2 diabetes since 2005. "
2.	Insulin Resistance 06/01/2007 - "Long-term treatment with glucagon-like peptide (GLP)-1 or its analog can improve insulin sensitivity. " 01/06/2013 - "This short term effect is probably due to an increased secretion of glucagon-like peptide and, as a consequence, an improvement in hepatic insulin sensitivity as well as the whole body glucose uptake. " 06/01/2021 - "One of the important incretins in the improvement of diabetes is glucagon-like peptide (GLP-1), which is secreted by the gut and reduces the apoptosis of pancreatic β-cells and improves insulin sensitivity. " 09/01/2017 - "Altered circulating concentrations of active glucagon-like peptide (GLP-1) and dipeptidyl peptidase 4 (DPP4) in obese subjects and their association with insulin resistance." 05/01/1999 - "To determine whether glucagon-like peptide (GLP)-1 increases insulin sensitivity in addition to stimulating insulin secretion, we studied totally depancreatized dogs to eliminate GLP-1's incretin effect. "
3.	Obesity 12/25/2015 - "A promising treatment for obesity involves the use of therapeutic agents that increase the level of the glucagon-like peptide (GLP-1) which reduces appetite and food intake. " 01/01/1983 - "It is concluded that the possible role of abnormalities of PP and enteroglucagon secretion in the pathogenesis of human obesity deserves further study." 06/01/2022 - "Therefore, the glucagon-like peptide type 1 receptor agonist (GLP-1) is indicated to treat obesity-related liver metabolic alterations. " 06/01/1999 - "Release of enteroglucagon from the ileum has probably contributed to weight control in bypass operations for obesity, but the effect has been obscured by the associated malabsorption. " 11/01/2019 - "Expert opinion: Analogues of glucagon-like peptide (GLP-1) have been developed for obesity but so far do not provide enough weight loss. "
4.	Weight Loss (Weight Reduction) 01/01/2023 - "Weight Loss Effects of Glucagon-Like Peptide-One Receptor Analog Treatment in a Severely Obese Patient During Hospital Admission." 02/06/2020 - "Glucagon-like peptide (GLP-1) analogs promote diabetes control and weight loss. " 12/01/2013 - "The efficacy and safety of glucagon-like peptide (GLP)-1 receptor agonists for weight loss in adult patients without diabetes is reviewed. " 03/01/2012 - "They do not have the benefit of weight loss offered by the glucagon-like polypeptide (GLP)-1 agonists. " 10/01/2002 - "The more dramatic effect seen in the surgical procedures to cause malabsorption is likely secondary to the bypass of the foregut resulting in increased weight loss and elevation of the enteroglucagon level."
5.	Hyperglycemia 10/01/2020 - "Glucagon-like peptide (GLP)-1 receptor agonists are the cornerstone in the treatment of hyperglycemia in many people suffering from type 2 diabetes (T2D). " 06/01/1996 - "Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide I(7-36) amide in type I diabetic patients." 07/05/2017 - "Glucagon-like peptide one (GLP-1)-based therapies for reducing hyperglycemia in type 2 diabetic patients are efficient, though some individuals develop GLP-1 resistance. " 03/01/2012 - "Drugs that augment the incretin system [glucagon like peptide (GLP) agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors] represent a novel class of anti-hyperglycemic agents that have shown to improve the health and survival of beta-cells (improvement in postprandial hyperglycemia) and suppress glucagon (improvement in fasting hyperglycemia). " 02/28/2023 - "Streptozotocin (STZ) impairs memory in rats through altering the central nervous systems (CNS) as a result of impaired cholinergic dysfunction, oxidative stress, persistent hyperglycemia, and alterations in the glucagon-like peptide (GLP). "

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Glucagon (Glukagon)
3.	Liraglutide
4.	Insulin (Novolin)
5.	Glucagon-Like Peptide 1 (GLP 1)
6.	Incretins
7.	Peptides (Polypeptides)
8.	Glucagon-Like Peptide-1 Receptor Agonists
9.	Gastric Inhibitory Polypeptide (Glucose Dependent Insulinotropic Peptide)
10.	Dipeptidyl-Peptidase IV Inhibitors

Related Therapies and Procedures

1.	Therapeutics
2.	Glycemic Control
3.	Injections
4.	Gluten-Free Diet
5.	Microspheres (Microsphere)