Methionine Enkephalin

One of the endogenous pentapeptides with morphine-like activity. It differs from LEU-ENKEPHALIN by the amino acid METHIONINE in position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN.

Also Known As:

Networked: 539 relevant articles (7 outcomes, 62 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mousa, Shaaban A: 6 articles (08/2013 - 08/2003)
2.	Schäfer, Michael: 6 articles (08/2013 - 08/2003)
3.	Bergasa, Nora V: 6 articles (04/2012 - 02/2002)
4.	Stein, Christoph: 4 articles (04/2009 - 08/2003)
5.	Griffin, Noreen: 3 articles (01/2015 - 01/2014)
6.	Shan, Fengping: 3 articles (01/2015 - 01/2014)
7.	Plotnikoff, Nicolas P: 3 articles (01/2015 - 01/2014)
8.	Wolf, Marion E: 3 articles (09/2013 - 03/2008)
9.	Mosnaim, Aron D: 3 articles (09/2013 - 03/2008)
10.	Yang, Jun: 3 articles (06/2011 - 12/2006)

Related Diseases

1.	Pain (Aches) 05/01/2012 - "Changes in spinal cord met-enkephalin levels and mechanical threshold values of pain after pulsed radio frequency in a spared nerve injury rat model." 07/15/2007 - "The pentapeptide methionine-enkephalin (Met-enk) is a natural opiate that inhibits signals of pain. " 03/01/2006 - "Complex regional pain syndrome and methionine-enkephalin." 01/01/2001 - "This demonstrates that the absence of myocardial ischemic pain in neuropathic diabetic patients is not accounted for by met-enkephalin action." 11/01/1998 - "Plasma met-enkephalin levels were 656% (p<0.05) and 301% (p<0.05) and cerebrospinal fluid met-enkephalin levels were 1481% (p<0.01) and 645% (p<0.05) higher when compared to healthy control and pain control patients, respectively. "
2.	Infection 02/01/2006 - "Our data demonstrated that methionine enkephalin maintains the viability of cells during the period of prolonged infection. " 02/01/2006 - "The roles of methionine enkephalin, as an immunomodulator, on immunodeficiency virus-induced apoptosis of lymphocytes during prolonged infection are still unclear. " 01/01/2001 - "Modulation of fas/fasL in a murine retroviral infection by AZT and methionine enkephalin." 03/01/1988 - "We have studied the effects of infusions of methionine-enkephalin on immune functions and clinical courses in seven patients with various stages of infection with human immunodeficiency virus (HIV). " 03/01/1988 - "Methionine-enkephalin as immunomodulator therapy in human immunodeficiency virus infections: clinical and immunological effects."
3.	Neoplasms (Cancer) 09/01/2014 - "Phase II human trials of met-enkephalin, case reports published by Berkson and Rubin, and the clinical experience of Bihari confirmed the potential role of LDN in treating pancreatic and other cancers. " 03/28/2014 - "The aim of this study was to investigate the immunological mechanisms by which synthetic methionine enkephalin (MENK) exerts therapeutic effects on tumor growth. " 01/01/1989 - "Several studies have reported the regulation of tumor growth by methionine enkephalin (ME). " 01/01/2015 - "Methionine enkephalin (MENK) inhibits tumor growth through regulating CD4+Foxp3+ regulatory T cells (Tregs) in mice." 09/01/2014 - "Met-enkephalin is involved in regulating cell proliferation and can inhibit cancer cell growth in multiple cell lines. "
4.	Cluster Headache (Cluster Headaches) 09/01/2013 - "Changes in plasma methionine-enkephalin levels associated with a cluster headache episode." 05/01/2012 - "Decreased plasma methionine-enkephalin levels in cluster headache patients." 09/01/1989 - "Low CSF met-enkephalin levels in cluster headache are elevated by acupuncture." 06/01/1991 - "We have previously demonstrated an increase in plasma met-enkephalin levels during the pain attacks in episodic cluster headache. " 10/01/1990 - "Increase in plasma methionine-enkephalin levels during the pain attack in episodic cluster headache."
5.	Leukemia 01/01/1983 - "The protective effects of methionine enkephalin as well as leucine enkephalin were studied in BDF1 mice inoculated with 1 X 10(4) and 1 X 10(2) cells of L1210 murine leukemia. " 09/01/1995 - "In this study we show that physiological concentrations of the endogenous opioid neuropeptide methionine-enkephalin (MET-ENK) and the synthetic enkephalins D-Ala2, Me-Phe4, Gly(ol)5 and D-Ala2, D-Leu5 are stimulants for the in vitro migration of pre-B acute lymphoblastoid leukemia (ALL) cells. " 07/01/1999 - "Previously, it was demonstrated that in vitro treatment of noninfected splenocytes and in vivo treatment of Friend leukemia virus (FLV)-infected mice with the combination of azidothymidine (AZT) and methionine enkephalin (MENK) significantly increases Type 1 cytokine levels and decreases Type 2 cytokines compared with treatment with only AZT. " 12/01/1996 - "The ability of spleen cells treated with methionine enkephalin (Met-ENK) in the presence of 3'-azido-3'-deoxythymidine (AZT) to produce cytokines and inhibit Friend leukemia virus (FLV) replication in Mus dunni cell cultures was investigated. " 05/01/2003 - "NALM-1 cells (a cell line derived from human pre-B leukemia) were exposed to the opioid pentapeptide methionine-enkephalin (Met-enkephalin) and/or to thiorphan, an inhibitor of the enzyme that degrades the enkephalins (membrane endopeptidase EC 3.4.24.11, CALLA, the CD10 marker). "

Related Drugs and Biologics

1.	beta-Endorphin (Endorphin, beta)
2.	Leucine Enkephalin
3.	Peptides
4.	Morphine (MS Contin)
5.	Catecholamines
6.	preproenkephalin
7.	Leucine (L-Leucine)
8.	Interferons
9.	Substance P
10.	Enkephalins

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Electroacupuncture
3.	Epidural Analgesia
4.	Pneumonectomy (Lung Volume Reduction)
5.	Anesthesia