Leucine Enkephalin

One of the endogenous pentapeptides with morphine-like activity. It differs from MET-ENKEPHALIN in the LEUCINE at position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN.

Also Known As:

Networked: 280 relevant articles (5 outcomes, 25 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yang, Jun: 5 articles (06/2011 - 01/2006)
2.	Liu, Wen-Yan: 3 articles (07/2009 - 01/2006)
3.	Schmidt, Brian L: 2 articles (07/2010 - 05/2010)
4.	Quang, Phuong N: 2 articles (07/2010 - 05/2010)
5.	Lin, Bao-Cheng: 2 articles (07/2009 - 12/2006)
6.	Yang, Yu: 2 articles (07/2009 - 06/2007)
7.	Wang, Gen: 2 articles (07/2009 - 01/2006)
8.	Wang, Cheng-hai: 2 articles (06/2007 - 01/2006)
9.	Chen, Jian-min: 2 articles (06/2007 - 01/2006)
10.	Caffrey, James L: 2 articles (10/2005 - 09/2003)

Related Diseases

1.	Myocardial Infarction 08/01/1985 - "A stable analogue of leu-enkephalin administered to the animals normalized metabolic parameters and improved the course of experimental myocardial infarction in rats." 12/01/1985 - "[Concentration of leu-enkephalin in the blood of acute myocardial infarct patients]." 02/01/1990 - "A histofluorescence study was made of catecholamine saturation of the adrenergic nervous plexuses of the intact zone of rabbit left ventricles and adrenal medullas on days 3 and 7 of experimental myocardial infarction induced by ligation of the anterior branch of the left coronary artery when dalargrin, a leucine-enkephalin analogue, was administered. " 02/01/1990 - "[Effect of the leucine enkephalin analog dalargin on the components of the sympathetico-adrenal system in experimental myocardial infarction]." 12/01/1986 - "The effect of an opioid hormone (Leu-enkephalin analog Tyr-Dala-Gly-Phe-Leu-Arg) on the healing of myocardial infarction caused by the ligation of the descending branch of the rabbit left coronary artery has been investigated. "
2.	Wounds and Injuries (Trauma) 02/01/1999 - "Plasma hydrolysis of leucine enkephalin was evaluated, together with several cellular immune parameters, in a homogeneous group of human subjects who had undergone severe trauma (proximal femur fracture); data obtained were compared with those obtained in an age-matched control group. " 02/01/1999 - "Trauma decreases leucine enkephalin hydrolysis in human plasma." 01/01/1990 - "Treatment with dynorphin antiserum significantly improved outcome after trauma as compared to control treatment with normal rabbit serum or leucine-enkephalin antiserum. " 09/01/1989 - "Thus, dalargin, a Soviet synthetic Leu-enkephalin analogue, possesses marked anti-stress and cardioprotective effects in severe thermal trauma. " 07/01/1987 - "Synthetic analog of leucine enkephalin--hexapeptide dalargin was shown to stimulate healing of skin wounds in rats, dogs and mini-pigs at local and parenteral administration in doses of 0.1-100 micrograms/kg. Acceleration of proliferation with an increase of fibroblast mitoses, earlier and active growth of vascular elements, rapid maturation of granulation tissue and accelerated epithelialization were observed."
3.	Carcinoma (Carcinomatosis) 01/01/1990 - "The mean serum concentration of leucine-enkephalin was significantly greater in the patients with carcinoma (1035 pg/ml) than in the control subjects (426 pg/ml). " 02/01/1992 - "Specimens of the sigmoid colon were obtained from male and female patients (n = 11) with carcinoma of the colon or rectum and studied immunohistochemically for vasoactive intestinal polypeptide-, somatostatin-, substance P-, neuropeptide Y-, calcitonin gene-related peptide-, met- and leu-enkephalin-, 5-hydroxytryptamine-, and dopamine beta-hydroxylase-containing nerves. " 04/01/1988 - "Biochemical demonstration of ACTH, PTH and calcitonin, and immunohistochemical demonstration of ACTH, bombesin, serotonin, prolactin, gastrin, VIP, leu-enkephalin, pancreatic polypeptide, beta-endorphin and sub P has been reported in breast carcinomas. " 01/01/1985 - "All samples (carcinoids, well-differentiated NE carcinoma, NE carcinomas of intermediate type, NE carcinomas of the small cell type) contained significant numbers of cells that immunostained for one or more of the following neuroendocrine markers tested: bombesin, calcitonin, ACTH, leu-enkephalin, gastrin, serotonin, somatostatin, alpha-melanocyte-stimulating hormone, vasoactive intestinal peptide, glucagon, insulin, substance P, and neuron-specific enolase. "
4.	Substance-Related Disorders (Drug Abuse) 11/01/2001 - "The use of naloxone hydrochloride (0.2-0.4 mg) in complex therapy of adolescent heroin addicts significantly prolonged the half-life of serum leu-enkephalin, slightly elevated the thresholds of thermal nociceptive reactions, and improved some clinical indices (considerably reduced drug addiction, eliminated affective disorders, etc.), which are important for deactualization of drug addiction and promoting remission."
5.	Mood Disorders (Mood Disorder) 11/01/2001 - "The use of naloxone hydrochloride (0.2-0.4 mg) in complex therapy of adolescent heroin addicts significantly prolonged the half-life of serum leu-enkephalin, slightly elevated the thresholds of thermal nociceptive reactions, and improved some clinical indices (considerably reduced drug addiction, eliminated affective disorders, etc.), which are important for deactualization of drug addiction and promoting remission."

Related Drugs and Biologics

1.	Methionine Enkephalin
2.	Dynorphins (Dynorphin)
3.	Naloxone (Narcan)
4.	Heroin (Diamorphine)
5.	beta-Endorphin (Endorphin, beta)
6.	Opioid Peptides (Opioid Peptide)
7.	preproenkephalin
8.	Ala(2)-Arg(6)- enkephalin-Leu
9.	Methionine (L-Methionine)
10.	Opioid Receptors (Opioid Receptor)

Related Therapies and Procedures

1.	Ligation
2.	Electroacupuncture
3.	Injections
4.	Intravenous Infusions
5.	Analgesia