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Enflurane (Ethrane)

An extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate.

Also Known As:

Ethrane; Abbott Brand of Enflurane; Alyrane; AstraZeneca Brand of Enflurane; Baxter Anaesthesia Brand of Enflurane; Enfran; Enlirane; Etran; Pisa Brand of Enflurane; Zeneca Brand of Enflurane; Ethane, 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoro-

Networked: 504 relevant articles (17 outcomes, 31 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Ethers: 174
  - Methyl Ethers: 14
    - Enflurane: 504

Experts

1.	Oksuz, Hafize: 2 articles (09/2011 - 02/2011)
2.	Yildiz, Huseyin: 2 articles (09/2011 - 02/2011)
3.	Senoglu, Nimet: 2 articles (09/2011 - 02/2011)
4.	Ugur, Nadiye: 2 articles (09/2011 - 02/2011)
5.	Dogan, Zafer: 2 articles (09/2011 - 02/2011)
6.	Schulz, R: 2 articles (01/2001 - 07/2000)
7.	Heusch, G: 2 articles (01/2001 - 07/2000)
8.	Weng, Hao: 1 article (02/2014)
9.	Liu, Haijian: 1 article (02/2014)
10.	Biter, Elif: 1 article (09/2011)

Related Diseases

1.	Nausea 12/01/1985 - "or in repeated doses of 1.25 mg i.v. is effective in the prevention and treatment of post-operative nausea and vomiting after enflurane anaesthesia." 12/01/1985 - "Droperidol prevents and treats nausea and vomiting after enflurane anaesthesia." 05/01/1985 - "Effect of a small dose of droperidol on nausea, vomiting and recovery after outpatient enflurane anaesthesia." 11/01/1993 - "Finally, patients who received enflurane for maintenance of anesthesia had a significantly higher frequency of nausea and vomiting than the propofol maintenance group. " 12/01/1987 - "Recovery after trichloroethylene was not significantly prolonged although postoperative analgesia by visual analogue was better, opiate analgesia was required less frequently and there was less nausea and vomiting than in either of the enflurane groups. "
2.	Vomiting 12/01/1985 - "or in repeated doses of 1.25 mg i.v. is effective in the prevention and treatment of post-operative nausea and vomiting after enflurane anaesthesia." 11/01/1989 - "The propofol group had significantly less (P less than 0.01) emesis in the recovery room than the enflurane group. " 08/01/1989 - "Vomiting occurred once with alfentanil and once with enflurane. " 01/01/1989 - "Although the alfentanil group had a higher incidence of apnoea, movement and vomiting (p less than 0.001), the enflurane group had a higher incidence of coughing (p less than 0.001) and shivering (p = 0.004). " 05/01/1985 - "It is concluded that although droperidol is a less effective antiemetic after outpatient than after inpatient enflurane anaesthesia, small doses of droperidol may be used for outpatients prone to vomiting to prevent delayed discharge from the clinic due to prolonged vomiting."
3.	Hypotension (Low Blood Pressure) 07/01/1990 - "Both agents were effective in producing hypotension, but enflurane was the more potent hypotensive agent in terms of MAC equivalents. " 03/01/1982 - "Deep enflurane induced hypotension resulted in significantly greater decreases in intestinal vascular resistance than either SNP or NTG. " 12/01/1993 - "Fifteen control patients had enflurane anaesthesia without hypotension. " 12/01/1984 - "Enflurane may induce myocardial ischaemia by redistributing coronary blood flow and/or by producing hypotension. " 12/01/1984 - "Enflurane 2.5% inspired after 15 min resulted in significant protection but caused hypotension after occlusion in 4 of 17 dogs. "
4.	Seizures (Seizure) 01/01/1977 - "This study assesses the effects of agents commonly used in anaesthesia on enflurane-induced seizure threshold and on established seizure activity, during steady state enflurane anaesthesia. " 02/01/2011 - "But motor and EEG seizure times were not prolonged by enflurane in the presence normocapnia. " 02/01/2011 - "High incidence of spike activity on EEG and grand mal seizure patterns could be induced by enflurane. " 10/01/1994 - "The cerebral cortex origin of enflurane-induced generalized seizure in cats." 06/01/1994 - "These CNS stimulants resulted in a 3-10% incidence of transient seizure and/or opisthotonus during the pre-enflurane period, but there was no correlation between DIZ-induced seizure and EIO. "
5.	Myocardial Ischemia (Ischemic Heart Diseases) 08/01/1993 - "These results show that, even with strict control of hemodynamics, isoflurane is associated with more myocardial ischemia than is enflurane." 01/01/1987 - "[Comparative evaluation of the effect of halothane and enflurane on the myocardial function and metabolism in patients with ischemic heart disease]." 08/01/1993 - "Myocardial ischemia: a comparison between isoflurane and enflurane in coronary artery bypass patients." 03/01/1988 - "[Enflurane-fentanyl anesthesia for non-cardiac surgery of patients with ischemic heart disease]." 06/01/2003 - "Inhalation of large dose of enflurane may result in increased myocardial ischemia reperfusion injury manifested by elevated levels of myocardial enzymes and OFR production."

Related Drugs and Biologics

1.	Halothane (Fluothane)
2.	Isoflurane
3.	Propofol (Diprivan)
4.	Fentanyl (Sublimaze)
5.	Nitrous Oxide (Laughing Gas)
6.	Oxygen
7.	Alfentanil (Alfenta)
8.	Midazolam (Versed)
9.	Antigens
10.	Thiopental (Pentothal)

Related Therapies and Procedures

1.	Anesthesia
2.	Cardiopulmonary Bypass (Heart-Lung Bypass)
3.	Balanced Anesthesia
4.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)
5.	Artificial Respiration (Mechanical Ventilation)