Endotoxins

Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells.

Networked: 937 relevant articles (22 outcomes, 69 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Martinho, Frederico C: 8 articles (07/2015 - 03/2008)
2.	Brandenburg, Klaus: 7 articles (06/2015 - 01/2007)
3.	Gomes, Brenda P F A: 7 articles (06/2015 - 03/2008)
4.	Gutsmann, Thomas: 5 articles (06/2015 - 05/2011)
5.	Heederik, Dick: 5 articles (07/2012 - 10/2004)
6.	Giamarellos-Bourboulis, Evangelos J: 5 articles (10/2009 - 01/2003)
7.	Nascimento, Gustavo G: 4 articles (07/2015 - 02/2014)
8.	Lehto, Markku: 4 articles (04/2015 - 02/2011)
9.	Keshavarzian, Ali: 4 articles (01/2015 - 10/2006)
10.	David, Sunil A: 4 articles (01/2013 - 03/2005)

Related Diseases

1.	Infection 03/01/2008 - "Our findings indicated that chemomechanical preparation with 2.5% NaOCl was moderately effective against bacteria but less effective against endotoxins in root canal infection. " 07/01/2015 - "This clinical study was conducted to correlate the levels of endotoxins and bacterial counts found in primary endodontic infection with the volume of periapical bone destruction determined by cone-beam computed tomography (CBCT) analysis. " 02/01/2011 - "This study has revealed that quantitative kinetic-turbidimetric and kinetic-chromogenic LAL methods are best fitted for the analysis of endotoxins in root canal infection, both being more precise and allowing better reproducibility compared with the endpoint-QCL assay." 11/01/1983 - "The pathogenicity of the predominantly non-capsulated, V-factor requiring haemophili that are commonly recovered from oral infections has been explored by studies of their endotoxins and infectivity as compared with those of Haemophilus influenzae. " 03/01/1961 - "These various findings can be explained by assuming that the pathological effects of endotoxins involve at least two unrelated mechanisms; (a) a primary toxicity illustrated in this study by the loss of weight and enhancement of infection resulting from the injection of small doses of toxin; (b) an immunological reaction with lethal consequences which became manifest only in animals sensitized to the endotoxin by prior exposure to Gram-negative bacilli."
2.	Sepsis (Septicemia) 05/12/2003 - "This acid labile enzyme is potentially useful in the treatment of sepsis, a serious condition during which endotoxins can migrate into the blood stream. " 06/01/1997 - "Kupffer cells were studied since they are central to the clearance of bacteria and endotoxins, and have been associated with hepatocellular dysfunction in sepsis. " 09/01/1983 - "The extension of the observations documented with this experimental model provide a firm foundation for productive future research into the precise role of bacterial endotoxins in the protection against, and exacerbation of, gram-negative bacterial sepsis." 06/25/2015 - "In this study, we physically modeled the influence of endotoxin-induced sepsis symptoms on human red blood cells (RBCs) by quantifying the impact of endotoxins on the cell mechanics by the analysis of Fourier-transformed mean square amplitude of shape fluctuation, called flicker spectroscopy. " 03/18/1989 - "Only after such comprehensive studies have been performed, it might be concluded that--as in the experimental animal--sepsis and MOF may not necessarily be caused by bacteria or their endotoxins, but by an untoward autodestructive and self-sustaining activation of angry leucocytes and mad macrophages."
3.	Wounds and Injuries (Trauma) 12/01/2005 - "It has been shown that trauma causes translocation of lipopolysaccharide (LPS) endotoxins from the gut. " 04/01/1975 - "These patterns were compared with those of acute ocular responses to various types of injuries caused by fromalin, bacterial endotoxins and immunological sensitization with bovine albumin. " 07/01/2001 - "At any time after burn trauma, endotoxins could be detected in the plasma of all patients. " 02/01/2000 - "Translocation of endotoxins was demonstrated for multiple injury but not for minor trauma such as isolated malleolar fractures. " 11/01/1987 - "With use of a quantitative limulus assay, the levels of circulating endotoxins were examined in a population of burn patients with injuries covering 1% to 88% of the total body surface area (TBSA). "
4.	Septic Shock (Toxic Shock Syndrome) 11/01/1971 - "[Studies of the mechanism of action of endotoxins in experimental endotoxic shock]." 11/01/2015 - "Important is the capture of Gram-negative bacteria, which can be involved in septic shock due to the production of endotoxins. " 05/18/2015 - "Moreover, AAGs can selectively control inflammatory responses induced in the presence of endotoxins to prevent septic shock. " 02/01/2014 - "The liver is one of the target organs damaged by septic shock, wherein the spread of endotoxins begins. " 10/01/2012 - "Additionally to the standard treatment of septic shock and multiorgan failure, haemoperfusion with LPS adsorber was performed to eliminate endotoxins from the bloodstream, and drotrecogin alfa was administered. "
5.	Asthma (Bronchial Asthma) 10/01/2004 - "In a previous study inverse associations between asthma and exposure to fungal spores and endotoxins in atopic farmers and positive associations with the same factors in non-atopic farmers were documented. " 01/01/2015 - "Linking Endotoxins, African Dust PM10 and Asthma in an Urban and Rural Environment of Puerto Rico." 01/01/2014 - "Based on data from environmental research on house dust mites and endotoxins, which are widely known as pollutants in bedding that cause asthma in pregnant women and children, this work was conducted to obtain basic data that can be used in future cohort studies that analyze links between distribution of biological hazards and physical features of residential environments. " 10/01/2012 - "Contradictory results have been found between endotoxins and asthma. " 07/01/2012 - "Endotoxins from gram-negative bacteria were the first agents associated with a reduced risk for asthma and atopy. "

Related Drugs and Biologics

1.	Antigens
2.	Cytokines
3.	Exotoxins
4.	Lactoferrin
5.	Complement System Proteins (Complement)
6.	Polymyxin B (Aerosporin)
7.	Peptides
8.	Lipoproteins (Lipoprotein)
9.	Fibrin
10.	Matrix Metalloproteinases

Related Therapies and Procedures

1.	Hemoperfusion
2.	Colectomy
3.	Transplantation (Transplant Recipients)
4.	Injections
5.	Plasma Exchange